Search

NG101 treatment for acute cervical spinal cord injury mitigates structural degeneration compared to placebo. Stratifying patients via MRI and electrophysiology identifies clinical responder subgroups, optimizing future trial designs.

Multi-ancestry and ancestry-stratified genome-wide analyses identify genetic variants associated with refractive error and enable construction of an enhanced polygenic predictor incorporating functional annotations.

The APOE-ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease, but it is not deterministic. Here, the authors show that common genetic variation changes how APOE-ε4 influences cognition.

Liposomal probes actuated by engineered peptide-based pores control MRI contrast by regulating water access to liposome-encapsulated gadolinium chelators and enable molecular target detection in vivo.

Transmission of Plasmodium falciparum relies on the development of gametocytes, which undergo extensive cellular remodelling. Here, the authors demonstrate that the PfGID E3 ubiquitin ligase complex affects gametocyte development by regulating key proteins, producing defective cells that cannot infect mosquitoes.

Growing demand for robust plasma and serum proteomics highlights the need for better standardization. Here, the authors introduce an open 211-peptide internal standard that enables consistent quantification, cross-platform alignment and clinical utility across serum and plasma studies.

This Review explores how quantum computing could support future smart grids, from converter to gird levels. It explains where quantum methods may help with hard optimization, analysis, control and security tasks, where they do not yet fit and what steps are needed to move from theory to practice.

Reducing or stopping immunosuppression in recipients of allografts has the potential to spare them from increased risk of infection, malignancy and cardiovascular events. Here, the authors report the results of a phase-I clinical trial evaluating the use of donor-derived dendritic cells as means to achieve operational tolerance in living-donor liver transplantation.

This study presents an organ-wide spatial transcriptomic analysis of human skin from different anatomical sites using a combination of MERFISH technology and existing datasets from healthy and diseased skin.

A causal debiasing framework provides accurate estimates of local prevalence and effective reproduction number for surveillance of SARS-CoV-2 cases using data from randomized testing schemes to model ascertainment bias in targeted subpopulation data.

Organic lasers, known for their colour purity, are emerging as next-generation light emitters. Here, the authors use a self-driving laboratory to discover soluble red-shifted emitters and automate the search for solution-processable laser dyes.

Annotating regulatory elements in domestic animal genomes is important to understand the mechanisms underlying gene regulation. Here, the authors use multi-omics data from sheep to map regulatory elements in the sheep genome.

Most advanced triple-negative breast cancers remain resistant to immunotherapy. Here, the authors discover that RIPK1-driven necroptosis in both tumor and stromal compartments is essential for effective immunogenic cell death-based therapy and immune checkpoint blockade.

This study mapped normative growth trajectories of 28 fetal brain phenotypes derived from 4,205 3D ultrasound scans collected across 7 international sites. The low variance between sites reinforces the principle that the brain develops similarly when environmental constraints are minimal.

Conventional ammonia synthesis is energy intensive. Here the authors explore the mechanism of light-driven ammonia synthesis through in situ spectroscopy and modelling, and demonstrate that certain AuRu plasmonic alloys are promising catalysts for this potentially more sustainable process.

The PCRCR complex of Plasmodium spp. binds basigin on the erythrocyte surface. While Rh5 of the complex is restricted to P. falciparum, PTRAMP, CSS and Ripr orthologs are present across the genus, for which the authors report common features.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Managing hydrocephalus relies on non-specific symptoms. Here, the authors report a 0.28-gram implant that measures intracranial pressure long term, tested in pediatric and adult patients.

Age-related microbiome changes increase medium-chain fatty acid-producing bacteria, driving GPR84-mediated myeloid inflammation, impaired vagal signalling and hippocampal dysfunction; targeting this gut–brain pathway restores memory in aged mice.

Artificial intelligence (AI) has demonstrated promise in predicting acutekidney injury (AKI), however, clinical adoption of these models requires interpretability and transportability across sites. Here, the authors develop an AKI prediction model and a measure for model transportability across six independent health systems.

BaTa₂S₅, which consists of alternating layers of TaS₂ and Ba₂TaS₄, is shown to host a triplet superconducting phase at high magnetic field. This triplet phase emerges from another—more conventional—superconducting state.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Variants of adeno-associated viruses displaying robust and widespread transduction in murine, porcine and non-human-primate kidneys, and in human kidney organoids, can be obtained via the cross-species cycling of capsid libraries in the different kidney models.

The first-in-human clinical trial of the LRRK2-targeting antisense oligonucleotide BIIB094 in Parkinson’s disease demonstrates that the treatment is well tolerated and produces dose-dependent reductions in cerebrospinal fluid levels of LRRK2 and phosphorylated Rab10, indicating successful target engagement.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

Aperiodic composite crystals were discovered that emulate 2D moiré materials, demonstrating a potentially scalable approach for producing moiré materials for next-generation electronics and a generalizable approach for realizing theoretical predictions of higher-dimensional quantum phenomena.

The study introduces radio interferometric multiplexed spectroscopy (RIMS), a method designed to efficiently monitor the radio emissions of massive samples of stars. Applying it to LOFAR data, the authors identify stellar bursts, offering clues to possible star–planet magnetic interactions.

A consensus cell type atlas for the fly brain provides both an intellectual framework and open-source toolchains for brain-scale comparative connectomics.

A modularized open-source pipeline for invasive brain signal decoding bridges the gap between closed-loop neuromodulation and clinical brain–computer interface approaches in a large patient cohort.

Genome-wide association analyses using data from 19 biobanks identify variants influencing risk of thyroid diseases and yield polygenic risk scores associated with features of aggressive thyroid cancer.

Some cancer patients first present with metastases where the location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

Cryo-electron microscopy structures of apolipoprotein B100 (apoB100) in complex with the LDL receptor (LDLR) provide insight into binding interfaces and explain how mutations in apoB100 or in LDLR can give rise to familial hypercholesterolaemia.

A cross-ancestry meta-analysis of genome-wide association studies identifies association signals for stroke and its subtypes at 89 (61 new) independent loci, reveals putative causal genes, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as potential drug targets, and provides cross-ancestry integrative risk prediction.