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Showing 201–250 of 2978 results
Advanced filters: Author: Alex Few Clear advanced filters
  • Whole-genome sequencing of more than 2,000 colorectal carcinoma samples provides a highly detailed view of the genomic landscape of this cancer and identifies new driver mutations.

    • Alex J. Cornish
    • Andreas J. Gruber
    • Richard S. Houlston
    ResearchOpen Access
    Nature
    Volume: 633, P: 127-136
  • Using second harmonic amplitude and phase measurements the authors characterize the alignment of water molecules in the Stern-layer and the work associated with water flipping on hematite electrodes, suggesting a causal relationship between water flipping and the oxygen evolution reaction overpotential.

    • Raiden Speelman
    • Ezra J. Marker
    • Franz M. Geiger
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-9
  • Efficient hydrogen production is a major societal challenge. Here the authors use operando neutron diffraction to quantitatively support the operating principle of a memory reactor that allows super-equilibrium operation of the water–gas shift reaction, which can also be used for steam methane reforming.

    • Daniel M. Telford
    • Alex Martínez Martín
    • John S. O. Evans
    ResearchOpen Access
    Nature Chemical Engineering
    Volume: 2, P: 447-455
  • Research now suggests that large language models (LLMs) are viable in silico models of human language processing. By examining multi-participant high-quality brain responses, researchers were able to break new ground in the validation of this proposal, which could dramatically reduce the barrier to studying how language is processed in the human brain.

    • Alex Murphy
    News & Views
    Nature Computational Science
    P: 1-2
  • While the STING-type-I interferon pathway plays a key role in anti-tumour immunity, current direct STING agonists have limited therapeutic benefit. Here, the authors identify ENPP1 as a safer and more effective STING-modulating target than direct STING agonism, and use an AI-based drug design platform to design the ENPP1-selective inhibitor ISM5939.

    • Congying Pu
    • Hui Cui
    • Alex Zhavoronkov
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-23
  • Time crystals spontaneously produce periodic oscillations that are robust to perturbations. A time crystal phase with a long coherence time has now been produced using the electron and nuclear spins of a semiconductor sample.

    • A. Greilich
    • N. E. Kopteva
    • M. Bayer
    Research
    Nature Physics
    Volume: 20, P: 631-636
  • Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

    • Matthew A. Reyna
    • David Haan
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17
  • Here the authors analyse the impact of space on haemoglobin gene regulation using data from NASA, JAXA and SpaceX i4 missions. They find that globin gene down-regulation leads to space anaemia with post-flight recovery, and reveal an adult-to-foetal globin switch activation.

    • Josef Borg
    • Conor Loy
    • Joseph Borg
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15
  • A lesson learned.

    • Alex Shvartsman
    Comments & Opinion
    Nature
    Volume: 521, P: 386
  • Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

    • Steven A. Kemp
    • Dami A. Collier
    • Ravindra K. Gupta
    Research
    Nature
    Volume: 592, P: 277-282
  • Using metabolic dysfunction-associated steatohepatitis-driven hepatocellular carcinoma mouse models, an ATP citrate lyase inhibitor reduces tumour burden and enhances efficacy of current standards of care.

    • Jaya Gautam
    • Jianhan Wu
    • Gregory R. Steinberg
    ResearchOpen Access
    Nature
    Volume: 645, P: 507-517
  • Cancers have complex genetic, microscopic and macroscopic features analysed using imaging and omics technologies, but integrating these data is challenging. A framework combining deep learning and path modelling to integrate imaging and omics data is presented, producing a unified model of disease.

    • Alex Ing
    • Alvaro Andrades
    • Jan O. Korbel
    ResearchOpen Access
    Nature Machine Intelligence
    Volume: 7, P: 1053-1075
  • The genomic landscape of diffuse gliomas remains to be characterised. Here, the authors perform whole genome sequencing of 403 tumours and identify recurrent coding and non-coding genetic mutations, their associations with clinical outcomes and potential therapeutic targets.

    • Ben Kinnersley
    • Josephine Jung
    • Keyoumars Ashkan
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18
  • Narcolepsy has genetic and environmental risk factors, but the specific genetic risk loci and interaction with environmental triggers are not well understood. Here, the authors identify genetic loci for narcolepsy, suggesting infection as a trigger and dendritic and helper T cell involvement.

    • Hanna M. Ollila
    • Eilon Sharon
    • Emmanuel J. Mignot
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13
  • The authors study the non-centrosymmetric achiral material InxTaS2 by angle-resolved photoemission spectroscopy and quantum oscillations. They find that it hosts an “ideal” Kramers nodal line, well isolated at the Fermi level.

    • Yichen Zhang
    • Yuxiang Gao
    • Ming Yi
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10
  • As Nature Chemical Biology approaches its third decade we asked a collection of chemical biologists, “What do you think are the most exciting frontiers or the most needed developments in your main field of research?” — here is what they said.

    • Lona M. Alkhalaf
    • Cheryl Arrowsmith
    • Georg Winter
    Special Features
    Nature Chemical Biology
    Volume: 21, P: 6-15
  • A pangenome of the Cannabis genus including 193 genomes demonstrates high variability in most of the genome but low diversity in cannabinoid synthesis genes and provides a resource for future genetic studies and crop optimization.

    • Ryan C. Lynch
    • Lillian K. Padgitt-Cobb
    • Todd P. Michael
    ResearchOpen Access
    Nature
    Volume: 643, P: 1001-1010
  • Electrical stimulation of the neuromuscular system holds promise for therapeutic biomedical applications, but is currently restricted by power. Here, the authors introduce fully implantable resonator-based designs achieving ±20 V compliance and >300 mW output, enabling multichannel, biphasic, current-controlled operation to evoke functional gate patterns for 6-weeks in freely behaving rats.

    • Alex Burton
    • Zhong Wang
    • Philipp Gutruf
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17
  • Workers’ skills shape their job opportunities and where they live, thus making skills a vital part of understanding cities and their economy. Modeling urban labor markets as occupation networks, this study finds that more-specific skill information better predicts career mobility and that workers tend toward jobs in cities where their skills are locally rare, thus raising their wages.

    • Morgan R. Frank
    • Esteban Moro
    • Iyad Rahwan
    Research
    Nature Cities
    Volume: 1, P: 94-104
  • The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

    • Ludmil B. Alexandrov
    • Jaegil Kim
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 94-101
  • A global model compiling seabird surveys finds that 37 seabird species and around 25% of the world’s tropical seabird individuals nest on atolls, where they act as major nutrient pumps within tropical oceans.

    • Sebastian Steibl
    • Simon Steiger
    • James C. Russell
    Research
    Nature Ecology & Evolution
    Volume: 8, P: 1907-1915
    • CHARLES ALEX. STEVENSON
    Research
    Nature
    Volume: 25, P: 102
    • ALEX. THURBURN
    Research
    Nature
    Volume: 54, P: 248
  • Antimicrobial resistance is a major global health threat and its development is promoted by antibiotic misuse. Here, the authors present an offline smartphone application for automated and standardized antibiotic susceptibility testing, to be deployed in resource-limited settings.

    • Marco Pascucci
    • Guilhem Royer
    • Mohammed-Amin Madoui
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10
  • Isolating and studying haematopoietic stem cells in young and aged mice demonstrates evolutionary processes related to blood production and provides a framework for interpreting future work using laboratory mice to study stem cell ageing.

    • Chiraag D. Kapadia
    • Nicholas Williams
    • Jyoti Nangalia
    ResearchOpen Access
    Nature
    Volume: 641, P: 681-689