Search

The study presents a recyclable polymer system that stores solar energy and releases it as hydrogen on demand, offering an efficient and sustainable route for renewable energy storage and fuel generation.

This study applies a global food and land system modelling framework to quantify the impact of 23 food system measures on 15 outcome indicators related to public health, the environment, social inclusion and the economy—from today until 2050.

There is a mismatch between emission estimates from global land use calculated from IAMs and countries’ greenhouse gas inventories. This study presents a method for reconciling these estimates by reallocating part of the land-use sink, facilitating progress assessment towards climate goals.

There lacks model comparison of global land use change projections. Here the authors explored how different long-term drivers determine land use and food availability projections and they showed that the key determinants population growth and improvements in agricultural efficiency.

Aberrant redox homeostasis links lipid metabolism and cell death programs. Here, authors reveal how cell stress reduces growth factor signaling, enriching polyunsaturated fatty acids in phospholipids and sensitizing membranes to oxidative damage.

This study examines the outcomes of dietary shifts across intrinsic and instrumental conservation perspectives, finding that most conservation benefits already come from a partial shift to healthier, more plant-based diets, whereas greater benefits depend on more targeted conservation action.

Zorya uses a membrane-anchored H⁺-driven rotary motor ZorAB to sense phage invasion and to recruit the intracellular effectors ZorC and ZorD that execute anti-phage defence.

The transition to sustainable diets is challenging for countries that face malnutrition and limited resources. Now a study explores how various dietary transformations in China can improve public health, make food affordable and reduce environmental impacts, while evaluating the feasibility of the diet changes.

Here the authors apply machine learning approaches to Alzheimer’s genetics, confirm known associations and suggest novel risk loci. These methods demonstrate predictive power comparable to traditional approaches, while also offering potential new insights beyond standard genetic analyses.

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

The effectiveness of the different policies and policy bundles for food systems transformation to achieve SDGs in China vary widely. Using an integrated modelling framework covering 18 indicators, this study compares the trade-offs and outcomes of efforts focused on dietary transitions, climate change mitigation and ecological conservation, and faster socioeconomic development, ultimately revealing that dietary shifts offer the most benefits.

The future of food prices is uncertain yet key for food security and climate mitigation policies. This study estimates future food prices for 136 countries and 11 distinct food groups, showing that future food prices will become less sensitive to agricultural market dynamics and land-based mitigation policies, given the global transition towards more complex and industrial food systems.

Achieving the Paris Agreement’s climate goals depends on safeguarding and monitoring the permanence of forest carbon stocks, as delays in addressing their vulnerability to disturbances drastically increase mitigation costs and efforts.

Schwab, Rao et al. report that Zeb1 mediates enhanced ferroptosis sensitivity in cancer cells after EMT activation, associated with altered expression of selected lipogenic enzymes and an subsequent increase in the PUFA:MUFA ratio.

To promote the recovery of the currently declining global trends in terrestrial biodiversity, increases in both the extent of land under conservation management and the sustainability of the global food system from farm to fork are required.

Cryptands and related molecules are macrocyclic polyethers capable of strongly binding cations. Here, the authors use orthoester exchange for the dynamic one-pot synthesis of crypates, which can bind cations and, given their constitutionally dynamic nature, can also be decomposed to release their guest.

A potential drug should specifically interact with its intended target in order to limit unwanted side effects. Here, the authors fabricate a biodegradable polymer nanoparticle with a fluorescent hepatic uptake transporter ligand to achieve targeted in vivosiRNA delivery and imaging of delivery.

Transformation to healthier and more sustainable diets in China can generate measurable benefits for nutrition, the environment and food affordability. Integrating multidimensional sustainability goals into China’s dietary guidelines can help to align food policy with long-term societal and environmental improvements.

Here the authors find one third of global sub-basins will face severe clean water scarcity in 2050. Nitrogen pollution aggravates water scarcity in >2,000 sub-basins thus 3 billion more people will be posed with severe water scarcity in 2050.

Ambitious climate policies can negatively impact the global poor by affecting income, food and energy prices. Here, the authors quantify this effect, and show that it can be compensated by national redistribution of the carbon pricing revenues in combination with international climate finance.

Existing datasets of nitrogen (N) balance in agriculture are often discrepant. Comparing 13 of them regarding five metrics (fertilizer application, manure application, biological N fixation, atmospheric deposition, and N harvested as crop products) over 1961–2015 reveals why. Recommendations for improving N quantification and an N budget benchmark dataset are also proposed.

This analysis of net-zero strategies designed in an iterative stakeholder dialogue finds that without behavioral change and with restriction of technologies, the target of greenhouse gas neutrality in the European Union cannot be reached.

Material characterization of liquids in extreme thermodynamic conditions is a challenging technical problem. Brillouin scattering metrology in an optical fibre design with a sealed liquid core now enables spatially resolved temperature and pressure measurements, using carbon disulfide as an example.

Polygenic risk scores for Alzheimer’s disease derived from individuals of European ancestry can show improved performance in multiancestry settings after incorporating genome-wide association summary statistics from diverse populations.

Income reduction in high-income regions is insufficient for mitigating food systems greenhouse gas emissions. A deeper transformation is required that changes consumption patterns and prices emissions.

Replacing 20% of per-capita ruminant consumption with microbial protein can offset future increases in global pasture area, cut annual deforestation and related CO₂ emissions in half, and lower methane emissions.

Wood used in construction stores carbon and reduces the emissions from steel and cement production. Transformation to timber cities while protecting forest and biodiversity is possible without significant increase in competition for land.

A modelling study argues that comprehensive policy change could limit Australia's environmental pollution while maintaining a materials-intensive path to economic growth. But other paths are worth considering. See Article p.49

Known genetic loci account for only a fraction of the genetic contribution to Alzheimer’s disease. Here, the authors have performed a large genome-wide meta-analysis comprising 409,435 individuals to discover 6 new loci and demonstrate the efficacy of an Alzheimer’s disease polygenic risk score.

Delaying climate mitigation requires large-scale carbon dioxide removal (CDR) in the second half of this century, with possible adverse effects. Under scenarios with no dependence on CDR technologies, this study examines the short- and long-term implications of climate mitigation for land-use and food systems.

Infection with SARS-COV-2 can result in self-limited upper airway infection or progress to a more systemic inflammatory condition including pneumonic COVID-19. Here the authors utilise a multi-omics approach to interrogate the immune response of patients with self-limiting upper respiratory SARS-CoV-2 infection and reveal a temporal immune trajectory they associate with viral containment and restriction from pneumonic progressive disease.

A significant challenge for policies aiming to reduce carbon emissions from deforestation is the avoidance of international carbon leakage. Research now shows, however, that even globally implemented forest conservation schemes could allow another type of carbon leakage through cropland expansion into non-forested areas.

Bioenergy has been widely viewed as an alternative for fossil fuels and an option for carbon dioxide removal, but there are doubts given the induced land-use changes. This study shows the importance of uniform regulation and comprehensive coverage of carbon-rich areas in reducing total emissions.

Competition between agriculture and land conservation may hinder climate and biodiversity targets. Here, the authors use global models integrating multiple spatial scales to assess how ambitious land conservation action and associated land-use dynamics could drive changes in landscape heterogeneity, pollination supply and soil loss.

As global population and food demand rises, it is increasingly unclear how reactive nitrogen pollution will be mitigated. Bodirsky et al.run a series of model simulations and show that even under ambitious mitigation, reactive nitrogen pollution is likely to exceed critical environmental thresholds in the year 2050.

Viiri and colleagues show that an orally administered transglutaminase 2 inhibitor prevented gluten-induced intestinal damage and inflammation at the transcriptional level.

In a world of deepening inequalities, climate polices might be feasible in high-income countries only. Here the authors find that overcoming global inequality through sustainable socio-economic development is critical for land-based mitigation in line with the Paris Agreement.

Current emissions scenarios include pathways that overshoot the temperature goals set out in the Paris Agreement and rely on future net negative emissions. Limiting overshoot would require near-term investment but would result in longer-term economic benefit.

The impact of rapidly falling costs of renewable energy and battery technology on long-term climate stabilization pathways is not well understood. Luderer et al. show that reduced renewable costs and climate policies will make electricity the cheapest energy carrier and can lead to electricity accounting for nearly two-thirds of global energy use by mid-century.

Current action is insufficient to meet both the Paris Agreement and the Sustainable Development Goals. Integrated model-based analysis shows that strong interventions across many dimensions, together with ambitious lifestyle change, are needed to enable real progress towards the UN Agenda 2030.

XFEL radiation is providing new opportunities for probing biological systems. Here the authors perform nanoscale x-ray imaging of microtubules with helical symmetry, by using imaging sorting and reconstruction techniques.

An integrated assessment model analysis shows that a moderately differentiated carbon price could achieve as much climate mitigation as a uniform carbon tax, avoiding concerns regarding equity between participating countries or sovereignty.

Urgent action is needed to ensure food security and mitigate climate change. Through a multi-model comparison exercise, this study shows the potential negative trade-offs between food security and climate change mitigation if mitigation policies are carelessly designed.

There lacks a consistent and holistic evaluation of co-benefits of different mitigation pathways in studies on Integrated Assessment Models. Here the authors quantify environmental co-benefits and adverse side-effects of a portfolio of alternative power sector decarbonisation pathways and show that the scale of co-benefits as well as profiles of adverse side-effects depend strongly on technology choice.

An integrated analysis of de novo and inherited coding variants in 42,607 individuals with autism spectrum disorder identifies 60 risk genes of which five have not previously been associated with neurodevelopmental disorders.