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Tirzepatide on obstructive sleep apnea-related cardiometabolic risk: secondary outcomes of the SURMOUNT-OSA randomized trial

In a prespecified secondary analysis of the SURMOUNT-OSA trial, tirzepatide improved cardiometabolic outcomes in patients with moderate-to-severe obstructive sleep apnea and obesity.

Atul Malhotra
Ronald Grunstein
Josef Bednarik
ResearchOpen Access15 Jan 2026
Nature Medicine

P: 1-7
Sleep and circadian rhythms in cardiovascular resilience: mechanisms, implications, and a Roadmap for research and interventions

In this Roadmap, Aggarwal and colleagues summarize current research and knowledge gaps on the relationship between sleep, circadian rhythms and cardiovascular resilience; highlight potential therapeutic targets and interventions for optimizing sleep and circadian rhythms to improve cardiovascular function and prevent disease; and outline research directions and opportunities, emphasizing the need for multidisciplinary collaboration.

Brooke Aggarwal
Yunling Gao
Donald Lloyd-Jones
Reviews18 Sept 2025
Nature Reviews Cardiology

Volume: 23, P: 116-130
Obstructive sleep apnoea heterogeneity and cardiovascular disease

In this Review, Redline and colleagues summarize our understanding of the shared risk factors and causal links between obstructive sleep apnoea (OSA) and cardiovascular disease and emerging knowledge on the heterogeneity of OSA. They also explore the potential role of new biomarkers for cardiovascular risk stratification in patients with OSA.

Susan Redline
Ali Azarbarzin
Yüksel Peker
Reviews10 Mar 2023
Nature Reviews Cardiology

Volume: 20, P: 560-573
Metabolomic profiles of sleep-disordered breathing are associated with hypertension and diabetes mellitus development

Sleep-disordered breathing (SDB) is a prevalent disorder linked to higher cardiovascular disease risk. Here, the authors show that summary scores reflecting SDB metabolite signatures are associated with increased risks for incident hypertension and diabetes, potentially useful in guiding risk stratification.

Ying Zhang
Bing Yu
Tamar Sofer
ResearchOpen Access28 Feb 2024
Nature Communications

Volume: 15, P: 1-16
Impact of reboxetine plus oxybutynin treatment for obstructive sleep apnea on cardiovascular autonomic modulation

Elisa Perger
Paolo Castiglioni
Carolina Lombardi
ResearchOpen Access23 Feb 2023
Scientific Reports

Volume: 13, P: 1-10

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Tirzepatide on obstructive sleep apnea-related cardiometabolic risk: secondary outcomes of the SURMOUNT-OSA randomized trial

Sleep and circadian rhythms in cardiovascular resilience: mechanisms, implications, and a Roadmap for research and interventions

Obstructive sleep apnoea heterogeneity and cardiovascular disease

Metabolomic profiles of sleep-disordered breathing are associated with hypertension and diabetes mellitus development

Impact of reboxetine plus oxybutynin treatment for obstructive sleep apnea on cardiovascular autonomic modulation

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