Nature Search

Voiceprints of cognitive impairment: analyzing digital voice for early detection of Alzheimer’s and related dementias

Neguine Rezaii
Bonnie Wong
Kathy Newell
ResearchOpen Access03 Nov 2025
npj Dementia

Volume: 1, P: 1-11
Disease progression modelling reveals heterogeneity in trajectories of Lewy-type α-synuclein pathology

Lewy body diseases exhibit notable clinical and pathological heterogeneity. Here, the authors found three distinct trajectories of Lewy body pathology that are associated with different clinicopathological characteristics.

Sophie E. Mastenbroek
Jacob W. Vogel
Oskar Hansson
ResearchOpen Access15 Jun 2024
Nature Communications

Volume: 15, P: 1-15
Author Correction: Voiceprints of cognitive impairment: analyzing digital voice for early detection of Alzheimer’s and related dementias

Neguine Rezaii
Bonnie Wong
Kathy Newell
Amendments and CorrectionsOpen Access31 Dec 2025
npj Dementia

Volume: 1, P: 1
Towards pharmacological prevention of Alzheimer disease

Advances in biomarkers, blood tests and disease-modifying therapies have created a credible path to clinical prevention of Alzheimer disease (AD). In this Perspective, the authors discuss promising approaches to the prevention of AD and highlight strategic gaps.

Jorge J. Llibre-Guerra
Eric M. McDade
Randall J. Bateman
Reviews03 Nov 2025
Nature Reviews Neurology

Volume: 21, P: 721-733
The role of cerebrospinal fluid and other biomarker modalities in the Alzheimer’s disease diagnostic revolution

A major transformation in dementia diagnosis and care appears imminent and will depend on three major types of biomarkers: molecular imaging, blood-based biomarkers and cerebrospinal fluid biomarkers. Each modality has unique strengths and limitations that suggest its optimal uses in research, clinical trials and clinical diagnosis.

Suzanne E. Schindler
Alireza Atri
Comments & Opinion18 May 2023
Nature Aging

Volume: 3, P: 460-462
Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer’s disease

Neuroinflammation is observed in Alzheimer’s disease. Here the authors show that 15 proteins related to inflammation found in CSF can potentially be used as a prognostic biomarker.

William T. Hu
Tugba Ozturk
Gloria Chiang
ResearchOpen Access28 Jun 2021
Nature Communications

Volume: 12, P: 1-12
Relationships of PGRN with sTREM2 in AD continuum and non-AD pathophysiology and their reciprocal roles in modulating amyloid pathology: two population-based study

Liang-Yu Huang
Chen-Chen Tan
Dariella Fernandez
ResearchOpen Access08 Jul 2025
Translational Psychiatry

Volume: 15, P: 1-11
Identifying healthy individuals with Alzheimer’s disease neuroimaging phenotypes in the UK Biobank

Azevedo et al. conduct a machine learning-based analysis of structural MRI data from multiple cohorts. The authors identify Alzheimer’s disease-like neuroimaging phenotypes associated with poorer cognitive performance in a healthy UK Biobank cohort, potentially highlighting a population at risk of Alzheimer’s disease.

Tiago Azevedo
Richard A. I. Bethlehem
Gail Li
ResearchOpen Access20 Jul 2023
Communications Medicine

Volume: 3, P: 1-15
A predictive model using the mesoscopic architecture of the living brain to detect Alzheimer’s disease

Inglese et al. develop a predictive model that computes multi-regional statistical morpho-functional mesoscopic traits from T1-weighted magnetic resonance imaging scans. Their model reliably discriminates people with Alzheimer’s disease-related pathologies from those without.

Marianna Inglese
Neva Patel
Eric O. Aboagye
ResearchOpen Access20 Jun 2022
Communications Medicine

Volume: 2, P: 1-16
Staging tau pathology with tau PET in Alzheimer’s disease: a longitudinal study

Shi-Dong Chen
Jia-Ying Lu
Michelle Zmuda
ResearchOpen Access18 Sept 2021
Translational Psychiatry

Volume: 11, P: 1-12
Plasma phosphorylated-tau181 as a predictive biomarker for Alzheimer’s amyloid, tau and FDG PET status

Xue-Ning Shen
Yu-Yuan Huang
Michelle Zmuda
ResearchOpen Access13 Nov 2021
Translational Psychiatry

Volume: 11, P: 1-10

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