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Showing 1–21 of 21 results
Advanced filters: Author: Alpaslan Tasdogan Clear advanced filters

  • Metabolomics analysis of the mouse embryo shows a metabolic shift towards the tricarboxylic acid cycle between gestational days 10.5 and 11.5, leading to the subsequent development of organ-specific metabolic programmes.

    • Ashley Solmonson
    • Brandon Faubert
    • Ralph J. DeBerardinis
    ResearchOpen Access
    Nature
    Volume: 604, P: 349-353

  • Cutaneous melanoma arises from malignant transformation of melanocytes in the epidermis and is a common cancer in many parts of the world. In this Primer, Tasdogan and colleagues outline the epidemiology, mechanisms, diagnosis, screening and prevention of cutaneous melanoma, and discuss advances in treatment.

    • Alpaslan Tasdogan
    • Ryan J. Sullivan
    • Dirk Schadendorf
    Reviews
    Nature Reviews Disease Primers
    Volume: 11, P: 1-20

  • Aldolase A is one of the glycolytic enzymes that regulate cancer cell proliferation. A new study identifies aldolase A as a critical node that, when inhibited in cancer cells, turns glycolysis into an ATP-consuming process. Targeting aldolase A to induce imbalanced glycolysis could overcome the intrinsic metabolic plasticity of cancer cells.

    • Luiza Martins Nascentes Melo
    • Feyza Cansiz
    • Alpaslan Tasdogan
    News & Views
    Nature Metabolism
    Volume: 7, P: 242-244

  • Analyses of tumor and bone marrow tissue from patients with glioblastoma demonstrate the presence of extracerebral niches that contained tumor-reactive and memory T cell subsets, including early stem-like phenotypes and stages, indicating antitumor CD8+ T cell differentiation in cranial bone marrow.

    • Celia Dobersalske
    • Laurèl Rauschenbach
    • Björn Scheffler
    ResearchOpen Access
    Nature Medicine
    Volume: 30, P: 2947-2956

  • Aspartate in the tumour environment activates the N-methyl-d-aspartate receptor in cancer cells to induce cellular programmes that increase the aggressiveness of metastasis.

    • Ginevra Doglioni
    • Juan Fernández-García
    • Sarah-Maria Fendt
    Research
    Nature
    Volume: 638, P: 244-250

  • Dysregulated growth and proliferation of tumors is related to metabolic changes. This protocol assesses metabolism in intact tumors using stable isotope-labeled nutrients delivered via bolus injection and continuous infusion in mice and humans.

    • Brandon Faubert
    • Alpaslan Tasdogan
    • Ralph J. DeBerardinis
    Protocols
    Nature Protocols
    Volume: 16, P: 5123-5145

  • Nucleotides are essential for different biological processes and have been also associated to cancer development. Depleting cellular nucleotides is a strategy commonly employed to target cancers. Here, the authors show that purine depletion induces serine synthesis to promote cancer cell migration and metastasis.

    • Mona Hoseini Soflaee
    • Rushendhiran Kesavan
    • Gerta Hoxhaj
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • Melanoma cells undergo less oxidative stress and less ferroptosis in lymph than in blood, owing to higher levels of oleic acid in lymph, and thus exposure to the lymphatic environment increases subsequent metastasis through blood.

    • Jessalyn M. Ubellacker
    • Alpaslan Tasdogan
    • Sean J. Morrison
    Research
    Nature
    Volume: 585, P: 113-118

  • Endothelial damage is a major component of acute lung injury pathogenesis. Here the authors show that in a mouse model of acute lung injury, glucocorticoids induce sphingosine kinase 1 production in macrophages, promoting endothelial barrier function and ameliorating the disease.

    • Sabine Vettorazzi
    • Constantin Bode
    • Jan P. Tuckermann
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-12

  • Chronic lymphocytic leukaemia (CLL) is characterized by cell-autonomous B-cell receptor (BcR)-mediated signalling of neoplastic B lymphocytes. Here the authors unveil the structural basis and diversity of activatory homotypic BcR contacts and link them with CLL heterogeneity and the clinical outcome.

    • Claudia Minici
    • Maria Gounari
    • Massimo Degano
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • Targeted radionuclide therapy (TRT) is a therapeutic modality that combines the strengths of radiotherapy and systemic molecularly targeted therapy. Over the past few years, new TRT agents have been developed against an expanding array of molecular targets, particularly in cancers with limited treatment options. The authors of this Review discuss these advances, focusing on what constitutes an optimal target and discussing lessons learned from past experience in order to broaden the scope of TRT.

    • Irina Primac
    • Kevin Tabury
    • Ken Herrmann
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 22, P: 869-894