Nature Search

Renal glucose transporters: novel targets for hyperglycemia management

New hypoglycemic agents that inhibit renal glucose reabsorption are valuable in the constant search for therapeutic tools that achieve glycemic control in patients with diabetes mellitus. In this Perspectives article, Amanda Mather and Carol Pollock discuss novel agents that inhibit the principal glucose transporter in the kidney, which can be added to the armamentarium against hyperglycemia.

Amanda Mather
Carol Pollock
Reviews30 Mar 2010
Nature Reviews Nephrology

Volume: 6, P: 307-311
Clinicogenomic landscape of pancreatic adenocarcinoma identifies KRAS mutant dosage as prognostic of overall survival

Analyses of clinical and genomic data from a cohort of 2,336 patients with pancreatic adenocarcinoma find that KRAS dosage gains are a hallmark of disease progression and are predictive of poor outcomes across different disease stages.

Anna M. Varghese
Maria A. Perry
Eileen M. O’Reilly
ResearchOpen Access03 Jan 2025
Nature Medicine

Volume: 31, P: 466-477
Worldwide migration of amplified insecticide resistance genes in mosquitoes

Michel Raymond
Amanda Callaghan
Nicole Pasteur
Research14 Mar 1991
Nature

Volume: 350, P: 151-153
The nephrotoxic effects of anti-cancer therapies: consensus report of the 34th Acute Disease Quality Initiative workgroup

Here, the authors provide guidance on the prevention, diagnosis and management of anticancer therapy nephrotoxicity in adult patients. They also define a research agenda focused on preventing and mitigating anticancer therapy toxicity, maximizing early detection of nephrotoxicity and enabling optimal drug dosing in patients with kidney disease.

Amanda DeMauro Renaghan
Marlies Ostermann
Mitchell H. Rosner
Reviews08 Dec 2025
Nature Reviews Nephrology

P: 1-18
Mapping genomic loci implicates genes and synaptic biology in schizophrenia

A genome-wide association study including over 76,000 individuals with schizophrenia and over 243,000 control individuals identifies common variant associations at 287 genomic loci, and further fine-mapping analyses highlight the importance of genes involved in synaptic processes.

Vassily Trubetskoy
Antonio F. Pardiñas
Jim van Os
Research08 Apr 2022
Nature

Volume: 604, P: 502-508
Application of high-throughput single-nucleus DNA sequencing in pancreatic cancer

Implementing high-throughput single-cell DNA sequencing for the study of solid tumours has been challenging. Here, the authors present an optimised approach for snap-frozen tissue single nuclei extraction and DNA sequencing, which can be applied to study pancreatic ductal adenocarcinoma evolution and heterogeneity.

Haochen Zhang
Elias-Ramzey Karnoub
Christine A. Iacobuzio-Donahue
ResearchOpen Access10 Feb 2023
Nature Communications

Volume: 14, P: 1-14
The impact of rare protein coding genetic variation on adult cognitive function

Analysis of rare coding variants in the UK Biobank identifies eight genes associated with adult cognitive function, including KDM5B. Rare and common variant signals overlap and contribute additively to the phenotype.

Chia-Yen Chen
Ruoyu Tian
Heiko Runz
ResearchOpen Access25 May 2023
Nature Genetics

Volume: 55, P: 927-938
Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

This study uses gene expression predictors for the dorsolateral prefrontal cortex and other brain regions to perform a transcriptomic imputation analysis of schizophrenia, identifying 413 genic associations across 13 brain regions and 36 significantly enriched pathways.

Laura M. Huckins
Amanda Dobbyn
Eli A. Stahl
Research25 Mar 2019
Nature Genetics

Volume: 51, P: 659-674
Purine nucleoside phosphorylase as a target for the treatment of interstitial cystitis/bladder pain syndrome with and without Hunner lesions

Lori A. Birder
Amanda Wolf-Johnston
Edwin K. Jackson
ResearchOpen Access19 Sept 2024
Scientific Reports

Volume: 14, P: 1-9
Characterization of the extracellular free water signal in schizophrenia using multi-site diffusion MRI harmonization

Suheyla Cetin-Karayumak
Amanda E. Lyall
Marek Kubicki
Research24 Apr 2023
Molecular Psychiatry

Volume: 28, P: 2030-2038
Defining diurnal fluctuations in mouse choroid plexus and CSF at high molecular, spatial, and temporal resolution

The choroid plexus (ChP) modulates cerebrospinal fluid (CSF) composition and the blood-CSF barrier. Here the authors show that the ChP is a critical circadian component with time-of-day variations in translation, barrier, and metabolism to alter CSF composition.

Ryann M. Fame
Peter N. Kalugin
Maria K. Lehtinen
ResearchOpen Access22 Jun 2023
Nature Communications

Volume: 14, P: 1-20
Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations

Targeted sequencing finds a higher burden of rare protein-truncating variants in constrained genes among schizophrenia cases of diverse ancestries. Meta-analyses with existing datasets show that this excess burden is consistent across five ancestral populations.

Dongjing Liu
Dara Meyer
Alexander W. Charney
ResearchOpen Access13 Mar 2023
Nature Genetics

Volume: 55, P: 369-376
Elucidating the relationship between white matter structure, demographic, and clinical variables in schizophrenia—a multicenter harmonized diffusion tensor imaging study

Johanna Seitz-Holland
Suheyla Cetin-Karayumak
Marek Kubicki
Research22 Jan 2021
Molecular Psychiatry

Volume: 26, P: 5357-5370
Racial and ethnic differences in prenatal exposure to environmental phenols and parabens in the ECHO Cohort

Michael S. Bloom
Sudhi Upadhyaya
Lynne M. Smith
ResearchOpen Access15 Feb 2025
Journal of Exposure Science & Environmental Epidemiology

Volume: 35, P: 992-1002
Dysregulation of mitochondrial and proteolysosomal genes in Parkinson’s disease myeloid cells

As part of Myeloid Cells in Neurodegenerative Disease (MyND) initiative, the authors profiled the transcriptome of primary monocytes and microglia from patients with Parkinson’s disease and controls, revealing the pathways and genes that are altered in the immune system of patients with Parkinson’s disease.

Elisa Navarro
Evan Udine
Towfique Raj
Research14 Sept 2021
Nature Aging

Volume: 1, P: 850-863
Host factors are associated with vaginal microbiome structure in pregnancy in the ECHO Cohort Consortium

Kimberly McKee
Christine M. Bassis
Lynne M. Smith
ResearchOpen Access23 May 2024
Scientific Reports

Volume: 14, P: 1-19
Publisher Correction: Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

Laura M. Huckins
Amanda Dobbyn
Eli A. Stahl
Amendments and Corrections13 May 2019
Nature Genetics

Volume: 51, P: 1068
White matter abnormalities across the lifespan of schizophrenia: a harmonized multi-site diffusion MRI study

Suheyla Cetin-Karayumak
Maria A. Di Biase
Marek Kubicki
Research11 Sept 2019
Molecular Psychiatry

Volume: 25, P: 3208-3219
Cognitive deficits, clinical variables, and white matter microstructure in schizophrenia: a multisite harmonization study

Johanna Seitz-Holland
Joanne D. Wojcik
Marek Kubicki
Research18 Aug 2022
Molecular Psychiatry

Volume: 27, P: 3719-3730
White matter changes in psychosis risk relate to development and are not impacted by the transition to psychosis

Maria A. Di Biase
Suheyla Cetin-Karayumak
Ofer Pasternak
Research24 May 2021
Molecular Psychiatry

Volume: 26, P: 6833-6844
The Role of microRNA Expression in Cortical Development During Conversion to Psychosis

Amanda B Zheutlin
Clark D Jeffries
Tyrone D Cannon
Research10 Feb 2017
Neuropsychopharmacology

Volume: 42, P: 2188-2195

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