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Showing 1–17 of 17 results
Advanced filters: Author: Andrei A. Korostelev Clear advanced filters

  • Structural ensembles of the 70S ribosome bound to cognate or near-cognate charged tRNAs in complex with EF-Tu illustrate the crucial role of the nucleotide G530 in decoding of mRNA, and demonstrate that translational fidelity results from direct control of GTPase by the decoding centre.

    • Anna B. Loveland
    • Gabriel Demo
    • Andrei A. Korostelev
    Research
    Nature
    Volume: 546, P: 113-117

  • GTP-binding protein 1 (GTPBP1) is GTPase closely related to elongation factor eEF1A, but the GTPBP1-mediated elongation is slow. Here, the authors show how the distinct GTPBP1 architecture leads to slow dissociation, delayed tRNA accommodation, an extended proofreading stage and higher accuracy of GTPBP1-mediated decoding.

    • Denis Susorov
    • Anna Miścicka
    • Andrei A. Korostelev
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-15

  • Three-dimensional structures of two natural RNA nanocages reveal unique quaternary structures without the contribution of proteins.

    • Xiaobin Ling
    • Dmitrij Golovenko
    • Wenwen Fang
    Research
    Nature
    Volume: 644, P: 1107-1115

  • A structure of the termination complex shows that release factors that recognize stop codons cause the peptide chain and mRNA to dissociate from the ribosome at the end of translation. A conserved motif in the release factor participates in hydrolysis of the final tRNA-peptide bond.

    • Martin Laurberg
    • Haruichi Asahara
    • Harry F. Noller
    Research
    Nature
    Volume: 454, P: 852-857

  • EF-G drives ribosomal translocation along mRNA. Time-resolved cryo-EM captured translocation with EF-G•GTP—without inhibitors—revealing how EF-G uses ribosome fluctuations to drive translocation and GTP hydrolysis to leave at the right moment.

    • Christine E. Carbone
    • Anna B. Loveland
    • Andrei A. Korostelev
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • Translational frameshifting is a mechanism that expands the coding capabilities of mRNA. Here, structures of 70S ribosome complexes with GTPase elongation factor G (EF-G), a +1-frameshifting-prone mRNA and tRNAs reveal the cooperation between the ribosome and EF-G to induce +1 frameshifting during the translocation step.

    • Gabriel Demo
    • Howard B. Gamper
    • Andrei A. Korostelev
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • The expansion of GGGGCC repeats in the C9ORF72 gene results in the production of disease causing abnormal proteins with polymeric glycine-arginine (poly-GR) and polymeric proline-arginine (poly-PR). Here the authors demonstrate a structural mechanism of how poly-GR and poly-PR inhibit translation and how they might also perturb ribosome assembly.

    • Anna B. Loveland
    • Egor Svidritskiy
    • Andrei A. Korostelev
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Time-resolved cryogenic electron microscopy structures of a ribosome during the delivery of aminoacyl-tRNA by EF-Tu•GTP capture 33 ribosomal states, enabling visualization of the initial selection, proofreading and peptidyl transfer stages.

    • Anna B. Loveland
    • Gabriel Demo
    • Andrei A. Korostelev
    Research
    Nature
    Volume: 584, P: 640-645

  • Alternative rescue factor B (ArfB) is an enzyme that releases peptides from stalled ribosomes to allow ribosome recycling. Here the authors carry-out cryo-EM analyses of 70S ribosomes complexed with ArfB on either a short or longer mRNA to reveal distinct modes of ArfB function.

    • Christine E. Carbone
    • Gabriel Demo
    • Andrei A. Korostelev
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-9

  • Ribosomes of all organisms have retained 5S rRNA as an autonomous rRNA species. Here the authors engineer a bacterial strain with ribosomes that do not have free 5S rRNA, and carry structural analyses that suggest the evolutionary preservation of 5S rRNA as an independent molecule is based on its role in the dynamic process of ribosome biogenesis.

    • Shijie Huang
    • Nikolay A. Aleksashin
    • Alexander S. Mankin
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • Adeno-associated viruses (AAVs) are vehicles for gene therapy in humans, but currently only a limited amount of AAV serotypes is available. Here, the authors identify a novel AAV, AAVv66, and demonstrate enhanced production yields, virion stability, and CNS transduction compared to the clinically approved serotype AAV2.

    • Hung-Lun Hsu
    • Alexander Brown
    • Guangping Gao
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • Accumulation of misfolded proteins results in the activation of the unfolded protein response (UPR) in the endoplasmic reticulum. Ire1 is important in this pathway and functions as a kinase and endoribonuclease. This paper solves the crystal structure of Ire1 kinase and shows that it undergoes spontaneous assembly into a rod-shaped oligomer. This arrangement positions the kinase domains for trans-autophosphorylation, orders the RNase domains and creates an interaction site for mRNA substrate binding.

    • Alexei V. Korennykh
    • Pascal F. Egea
    • Peter Walter
    Research
    Nature
    Volume: 457, P: 687-693

  • A eukaryotic viral internal ribosome entry site (IRES) element is described that binds both bacterial and eukaryotic ribosomes and initiates translation in both, demonstrating that RNA structure-based initiation can occur in both these domains of life, although in bacteria the element uses a mechanism that differs from that in eukaryotes.

    • Timothy M. Colussi
    • David A. Costantino
    • Jeffrey S. Kieft
    Research
    Nature
    Volume: 519, P: 110-113