Nature Search

A benchmark of expert-level academic questions to assess AI capabilities

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Long Phan
Alice Gatti
Davide Scaramuzza
ResearchOpen Access28 Jan 2026
Nature

Volume: 649, P: 1139-1146
Deleterious variants in the autophagy-related gene RB1CC1/FIP200 impair immunity to SARS-CoV-2

The variability in clinical outcomes of SARS-CoV-2 infection is partly due to deficiencies in production or response to type I interferons (IFN). Here, the authors describe a FIP200-dependent lysosomal degradation pathway, independent of canonical autophagy and type I IFN, that restricts SARS-CoV-2 replication, offering insights into critical COVID-19 pneumonia mechanisms.

Lili Hu
Renee M. van der Sluis
Trine H. Mogensen
ResearchOpen Access27 Nov 2025
Nature Communications

Volume: 16, P: 1-23
The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflicts

Epigenetic alterations are frequent in human malignancies and have been shown to threaten genome integrity. Here the authors show that a chromatin network prevents R-loops and transcription-replication conflicts from genomic instability and mutagenic signatures frequently associated with cancer.

Aleix Bayona-Feliu
Emilia Herrera-Moyano
Andrés Aguilera
ResearchOpen Access28 Oct 2023
Nature Communications

Volume: 14, P: 1-16
Acute and Sustained Effects of Aerosolized vs. Bolus Administration Surfactant on Pulmonary Mechanics and Systemic and Cerebral Haemodinamic in Premature Lambs with Respiratory Distress Syndrome

C Rey-Santano
V E Mielgo
X Murgia
Research01 Nov 2011
Pediatric Research

Volume: 70, P: 549
Different Cerebral Hemodynamic Patterns of Aerosolized and Instilled Surfactant in Preterm Lambs with Respiratory Distress Syndrome

X Murgia
E Gastiasoro-Cuesta
C Rey-Santano
Research01 Nov 2011
Pediatric Research

Volume: 70, P: 693
Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder

Genome-wide analyses identify 30 independent loci associated with obsessive–compulsive disorder, highlighting genetic overlap with other psychiatric disorders and implicating putative effector genes and cell types contributing to its etiology.

Nora I. Strom
Zachary F. Gerring
Manuel Mattheisen
ResearchOpen Access13 May 2025
Nature Genetics

Volume: 57, P: 1389-1401
Highly entangled polyradical nanographene with coexisting strong correlation and topological frustration

The design of open-shell nanographenes is commonly limited to systems featuring a single magnetic origin. Now a strategy that combines topological frustration and electron–electron interactions has been developed to generate a butterfly-shaped nanographene that hosts four highly entangled π-spins and exhibits both ferromagnetic and anti-ferromagnetic coupling.

Shaotang Song
Andrés Pinar Solé
Jiong Lu
Research19 Feb 2024
Nature Chemistry

Volume: 16, P: 938-944
Impact of SARS-CoV-2 infection therapies on the risk of venous thromboembolism and cardiovascular events from the SEMI-COVID-19 Registry

Crhistian-Mario Oblitas
Pablo Demelo-Rodríguez
Hector Meijide Míguez
ResearchOpen Access05 Mar 2025
Scientific Reports

Volume: 15, P: 1-13
Designing highly delocalized solitons by harnessing the structural parity of π-conjugated polymers

An on-surface synthetic route for the regio- and stereoselective coupling of indenyl moieties, affording the design of π-conjugated acenoindenylidene polymers on Au(111), is reported. The relationship between the structural parity of the polymers and their electronic properties reveals the emergence of highly delocalized soliton quasiparticles in odd-membered polymers.

Kalyan Biswas
Jesús Janeiro
David Écija
Research16 Oct 2024
Nature Synthesis

Volume: 4, P: 233-242
European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation

The genetic basis of atopic dermatitis is not fully understood. Here, the authors find 91 genetic loci associated with atopic dermatitis in a GWAS of >1million individuals, which highlight the importance of systemic immune regulation.

Ashley Budu-Aggrey
Anna Kilanowski
Lavinia Paternoster
ResearchOpen Access04 Oct 2023
Nature Communications

Volume: 14, P: 1-18
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Observation of charge–parity symmetry breaking in baryon decays

The LHCb experiment at CERN has observed significant asymmetries between the decay rates of the beauty baryon and its CP-conjugated antibaryon, thus demonstrating CP violation in baryon decays.

R. Aaij
A. S. W. Abdelmotteleb
G. Zunica
ResearchOpen Access16 Jul 2025
Nature

Volume: 643, P: 1223-1228
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Harmful R-loops are prevented via different cell cycle-specific mechanisms

Different factors protect cells from harmful R-loops, but the way these are formed is still unclear. Authors show here that R-loops form co-transcriptionally by different manners and cells possess specialized mechanisms to prevent them in each case, a major mechanism being independent of replication and another one being linked to replication.

Marta San Martin-Alonso
María E. Soler-Oliva
Andrés Aguilera
ResearchOpen Access22 Jul 2021
Nature Communications

Volume: 12, P: 1-14
Mortality reduction in older COVID-19-patients hospitalized in Spain during the second pandemic wave from the SEMI-COVID-19 Registry

José-Manuel Casas-Rojo
Juan-Miguel Antón-Santos
Hector Meijide Míguez
ResearchOpen Access18 Oct 2023
Scientific Reports

Volume: 13, P: 1-18
Genotyping, sequencing and analysis of 140,000 adults from Mexico City

Genotype and exome sequencing of 150,000 participants and whole-genome sequencing of 9,950 selected individuals recruited into the Mexico City Prospective Study constitute a valuable, publicly available resource of non-European sequencing data.

Andrey Ziyatdinov
Jason Torres
Roberto Tapia-Conyer
ResearchOpen Access11 Oct 2023
Nature

Volume: 622, P: 784-793
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Reduced glomerular filtration rate (eGFR) is a hallmark of chronic kidney disease. Here, Pattaro et al. conduct a meta-analysis to discover several new loci associated with variation in eGFR and find that genes associated with eGFR loci often encode proteins potentially related to kidney development.

Cristian Pattaro
Alexander Teumer
Caroline S. Fox
ResearchOpen Access21 Jan 2016
Nature Communications

Volume: 7, P: 1-19
Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

Inborn errors of the alternative NF-κB pathway in humans impair the development of AIRE-expressing medullary thymic epithelial cells, thereby underlying the production of autoantibodies against type I IFNs and predisposition to viral diseases

Tom Le Voyer
Audrey V. Parent
Anne Puel
ResearchOpen Access08 Nov 2023
Nature

Volume: 623, P: 803-813
Tracheal fluid (TF) saturated phosphatidylcholine (Sat. PC) and surfactant protein A (SP-A) in newborns with congenital diaphragmatic hernia (CDH)† 980

Fernando Moya
Vickey Thomas
Pedro Serrano
Research01 Apr 1997
Pediatric Research

Volume: 41, P: 166
Differential expression of proliferation and immune response genes between children and adults influences survival of diffuse large B cell lymphoma

Tamara Mangiaterra
Ruth Alonso-Alonso
Paola Chabay
ResearchOpen Access03 Jun 2025
Scientific Reports

Volume: 15, P: 1-9
Author Correction: Genotyping, sequencing and analysis of 140,000 adults from Mexico City

Andrey Ziyatdinov
Jason Torres
Roberto Tapia-Conyer
Amendments and CorrectionsOpen Access08 Feb 2024
Nature

Volume: 626, P: E18
Automated methodology for optimal selection of minimum electrode subsets for accurate EEG source estimation based on Genetic Algorithm optimization

Andres Soler
Luis Alfredo Moctezuma
Marta Molinas
ResearchOpen Access02 Jul 2022
Scientific Reports

Volume: 12, P: 1-18
A machine learning approach to identify patients at risk for long-term consequences after pulmonary embolism

Stephan Nopp
Clemens Spielvogel
H. M. Bui
ResearchOpen Access24 Sept 2025
Scientific Reports

Volume: 15, P: 1-12
A first update on mapping the human genetic architecture of COVID-19

Gita A. Pathak
Juha Karjalainen
J. Kenneth Baillie
ResearchOpen Access03 Aug 2022
Nature

Volume: 608, P: E1-E10
The DeepFish computer vision dataset for fish instance segmentation, classification, and size estimation

Nahuel Garcia-d’Urso
Alejandro Galan-Cuenca
Gabriel Soler-Capdepón
ResearchOpen Access09 Jun 2022
Scientific Data

Volume: 9, P: 1-7
Clinical characterization and outcomes of 85 patients with neurosarcoidosis

Manuel Ramos-Casals
Roberto Pérez-Alvarez
A. Sisó-Almirall
ResearchOpen Access02 Jul 2021
Scientific Reports

Volume: 11, P: 1-14
International consensus recommendations on the diagnostic work-up for malformations of cortical development

Malformations of cortical development (MCDs) are neurodevelopmental disorders that result from abnormal development of the cerebral cortex in utero. In this Consensus Statement, the international MCD network Neuro-MIG provides recommendations to aid both expert and non-expert clinicians in the diagnostic work-up of MCDs.

Renske Oegema
Tahsin Stefan Barakat
Nataliya Di Donato
ReviewsOpen Access07 Sept 2020
Nature Reviews Neurology

Volume: 16, P: 618-635
Comparison between two strategies for umbilical cord blood collection

P Solves
R Moraga
E Franco
Research14 Feb 2003
Bone Marrow Transplantation

Volume: 31, P: 269-273
Effects of attachment-based compassion therapy (ABCT) on brain-derived neurotrophic factor and low-grade inflammation among fibromyalgia patients: A randomized controlled trial

Jesus Montero-Marin
Laura Andrés-Rodríguez
Javier Garcia-Campayo
ResearchOpen Access30 Oct 2019
Scientific Reports

Volume: 9, P: 1-14
Human genetic and immunological determinants of critical COVID-19 pneumonia

The COVID Human Genetic Effort examines the molecular, cellular and immunological determinants of the various SARS-CoV-2-related disease manifestations by searching for causal errors of immunity.

Qian Zhang
Paul Bastard
Jean-Laurent Casanova
Reviews28 Jan 2022
Nature

Volume: 603, P: 587-598
The maternal genetic make-up of the Iberian Peninsula between the Neolithic and the Early Bronze Age

Anna Szécsényi-Nagy
Christina Roth
Kurt W. Alt
ResearchOpen Access15 Nov 2017
Scientific Reports

Volume: 7, P: 1-15
Optimisation of a Novel Spiral-Inducing Bypass Graft Using Computational Fluid Dynamics

Andres Ruiz-Soler
Foad Kabinejadian
Amir Keshmiri
ResearchOpen Access12 May 2017
Scientific Reports

Volume: 7, P: 1-14
Survival impact of primary tumor resection in de novo metastatic breast cancer patients (GEICAM/El Alamo Registry)

Sara Lopez-Tarruella
M. J. Escudero
E. Carrasco
ResearchOpen Access27 Dec 2019
Scientific Reports

Volume: 9, P: 1-12
Studying severe long COVID to understand post-infectious disorders beyond COVID-19

Petter Brodin
Giorgio Casari
Jean-Laurent Casanova
Correspondence05 Apr 2022
Nature Medicine

Volume: 28, P: 879-882
Risk factors for developing ventilator-associated lower respiratory tract infection in patients with severe COVID-19: a multinational, multicentre study, prospective, observational study

Luis Felipe Reyes
Alejandro Rodriguez
Neus Guasch
ResearchOpen Access21 Apr 2023
Scientific Reports

Volume: 13, P: 1-15
Comparison of seven prognostic tools to identify low-risk pulmonary embolism in patients aged <50 years

Luis Jara-Palomares
Maria Alfonso
Abilio Reis
ResearchOpen Access27 Dec 2019
Scientific Reports

Volume: 9, P: 1-10
Virological outcome among HIV infected patients transferred from pediatric care to adult units in Madrid, Spain (1997–2017)

Carolina Beltrán-Pavez
Miguel Gutiérrez-López
Elisa Lazzari
ResearchOpen Access09 Oct 2020
Scientific Reports

Volume: 10, P: 1-13
Acute and sustained effects of aerosolized vs. bolus surfactant therapy in premature lambs with respiratory distress syndrome

Carmen Rey-Santano
Victoria E. Mielgo
Xabier Murgia
Research12 Feb 2013
Pediatric Research

Volume: 73, P: 639-646

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