Nature Search

Neuronal cell death and tPA

Stella E. Tsirka
Andrew D. Rogove
Sidney Strickland
Research14 Nov 1996
Nature

Volume: 384, P: 123-124
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Large genome-wide meta-analysis of clinically diagnosed late-onset Alzheimer’s disease (LOAD) from 94,437 individuals identifies new LOAD risk loci and implicates Aβ formation, tau protein binding, immune response and lipid metabolism.

Brian W. Kunkle
Benjamin Grenier-Boley
Margaret A. Pericak-Vance
Research28 Feb 2019
Nature Genetics

Volume: 51, P: 414-430
Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia

Mikael J.L. Eliasson
Kenji Sampei
Valina L. Dawson
Research01 Oct 1997
Nature Medicine

Volume: 3, P: 1089-1095
Parity and lactation induce T-cell-mediated breast cancer protection

Parity induces an accumulation of CD8⁺ T cells, including cells with a tissue-resident-memory-like phenotype within human normal breast tissue, offering long-term protection against triple-negative breast cancer.

Balaji Virassamy
Franco Caramia
Sherene Loi
ResearchOpen Access20 Oct 2025
Nature

Volume: 649, P: 449-459
Human infections with highly pathogenic avian influenza A(H5N1) viruses in the United States from March 2024 to May 2025

In an updated report on 70 laboratory-confirmed highly pathogenic avian influenza A H5N1 cases in the USA between March 2024 and May 2025, the absence of human-to-human transmission to date was confirmed, with no known mutations of resistance to neuroaminidase inhibitors.

Melissa A. Rolfes
Krista Kniss
Sonja J. Olsen
Research25 Jul 2025
Nature Medicine

Volume: 31, P: 3889-3898
Why rankings of biomedical image analysis competitions should be interpreted with care

Biomedical image analysis challenges have increased in the last ten years, but common practices have not been established yet. Here the authors analyze 150 recent challenges and demonstrate that outcome varies based on the metrics used and that limited information reporting hampers reproducibility.

Lena Maier-Hein
Matthias Eisenmann
Annette Kopp-Schneider
ResearchOpen Access06 Dec 2018
Nature Communications

Volume: 9, P: 1-13
GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Genome-wide analyses identify common variants associated with 11 distinct neuropathology endophenotypes, providing insights into the mechanisms underlying the genetic risk of Alzheimer’s disease and related dementias.

Lincoln M. P. Shade
Yuriko Katsumata
David W. Fardo
ResearchOpen Access08 Oct 2024
Nature Genetics

Volume: 56, P: 2407-2421
Hematopoietic Cell Transplantation after Administration of High-Dose Busulfan in Murine Globoid Cell Leukodystrophy (the Twitcher Mouse)

Andrew M Yeager
Mitsuko Shinohara
Charlotte Shinn
Research01 Mar 1991
Pediatric Research

Volume: 29, P: 302-305
Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

Fine-mapping of causal variants and integration of epigenetic and chromatin conformation data identify likely target genes for 150 breast cancer risk regions.

Laura Fachal
Hugues Aschard
Alison M. Dunning
Research07 Jan 2020
Nature Genetics

Volume: 52, P: 56-73
New insights into the genetic etiology of Alzheimer’s disease and related dementias

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

Céline Bellenguez
Fahri Küçükali
Jean-Charles Lambert
ResearchOpen Access04 Apr 2022
Nature Genetics

Volume: 54, P: 412-436
Adaptative survival of Aspergillus fumigatus to echinocandins arises from cell wall remodeling beyond β−1,3-glucan synthesis inhibition

Echinocandins inhibit the biosynthesis of β−1,3-glucan, an essential component of the fungal cell wall, but their efficacy against the pathogen Aspergillus fumigatus is limited. Here, Dickwella Widanage et al. show that A. fumigatus responds to echinocandin treatment by remodelling various cell wall polymers, thus maintaining cell wall integrity and modulating the permeability and circulation of the drug in the cell wall.

Malitha C. Dickwella Widanage
Isha Gautam
Tuo Wang
ResearchOpen Access31 Jul 2024
Nature Communications

Volume: 15, P: 1-13
Correction: Corrigendum: The abundant marine bacterium Pelagibacter simultaneously catabolizes dimethylsulfoniopropionate to the gases dimethyl sulfide and methanethiol

Jing Sun
Jonathan D. Todd
Stephen J. Giovannoni
Amendments and Corrections03 Oct 2016
Nature Microbiology

Volume: 1, P: 1
What happens to patients who have their asthma device switched without their consent?

Scott Doyle
Andrew Lloyd
David Price
Research19 Feb 2010
Primary Care Respiratory Journal

Volume: 19, P: 131-139
S-Nitrosothiols signal the ventilatory response to hypoxia

Andrew J. Lipton
Michael A. Johnson
Benjamin Gaston
Research13 Sept 2001
Nature

Volume: 413, P: 171-174
Structural adaptation of fungal cell wall in hypersaline environment

Solid-state NMR snapshots of Aspergillus sydowii and other halophilic fungal species reveal the structural rearrangement of polysaccharides and proteins, which create a thick, stiff and hydrophobic cell wall to withstand external stress and thrive in hypersaline environment

Liyanage D. Fernando
Yordanis Pérez-Llano
Tuo Wang
ResearchOpen Access04 Nov 2023
Nature Communications

Volume: 14, P: 1-13
Genome-wide association study identifies novel breast cancer susceptibility loci

Previous work has identified several genes where mutations lead to breast cancer, but other genetic and environmental factors must still be accounted for. A large study of genetic association with breast cancer points to four novel genes and many more genetic markers that should be pursued for their link to cancer susceptibility.

Douglas F. Easton
Karen A. Pooley
Bruce A. J. Ponder
Research28 Jun 2007
Nature

Volume: 447, P: 1087-1093
Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study

APOE is the major genetic risk factor for Alzheimer’s disease. In a large number of neuropathologically confirmed cases and controls, the impact of different APOE genotypes on Alzheimer’s dementia risk was greater than previously thought and APOE2 homozygotes had an exceptionally low risk.

Eric M. Reiman
Joseph F. Arboleda-Velasquez
Yi Zhao
ResearchOpen Access03 Feb 2020
Nature Communications

Volume: 11, P: 1-11
A grass-specific cellulose–xylan interaction dominates in sorghum secondary cell walls

Sorghum is a source of lignocellulosic biomass for the production of renewable fuels. Here the authors characterise the sorghum secondary cell wall using multi-dimensional magic angle spinning solid-state NMR and present a model dominated by interactions between three-fold screw xylan and amorphous cellulose.

Yu Gao
Andrew S. Lipton
Jenny C. Mortimer
ResearchOpen Access27 Nov 2020
Nature Communications

Volume: 11, P: 1-10
The abundant marine bacterium Pelagibacter simultaneously catabolizes dimethylsulfoniopropionate to the gases dimethyl sulfide and methanethiol

Pelagibacter simultaneously produces the biogenic gases methanethiol and dimethyl sulfide from dimethylsulfoniopropionate, regulated by a kinetic switch that balances DMSP allocation between each pathway depending on cellular sulfur demands.

Jing Sun
Jonathan D. Todd
Stephen J. Giovannoni
Research16 May 2016
Nature Microbiology

Volume: 1, P: 1-5
Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Brian W. Kunkle
Benjamin Grenier-Boley
Margaret A. Pericak-Vance
Amendments and Corrections15 Aug 2019
Nature Genetics

Volume: 51, P: 1423-1424
Author Correction: GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Lincoln M. P. Shade
Yuriko Katsumata
David W. Fardo
Amendments and CorrectionsOpen Access17 Jun 2025
Nature Genetics

Volume: 57, P: 1788
Publisher Correction: GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Lincoln M. P. Shade
Yuriko Katsumata
David W. Fardo
Amendments and CorrectionsOpen Access17 Jun 2025
Nature Genetics

Volume: 57, P: 1791
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Sven van der Lee, Julie Williams, Gerard Schellenberg and colleagues identify rare coding variants in PLCG2, ABI3 and TREM2 associated with Alzheimer's disease. These genes are highly expressed in microglia and provide additional evidence that the microglia-mediated immune response contributes to the development of Alzheimer's disease.

Rebecca Sims
Sven J van der Lee
Gerard D Schellenberg
Research17 Jul 2017
Nature Genetics

Volume: 49, P: 1373-1384
CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers

Nichola Johnson
Sarah Maguire
Olivia Fletcher
ResearchOpen Access26 Jan 2021
British Journal of Cancer

Volume: 124, P: 842-854
Blood–brain barrier disruption and ventricular enlargement are the earliest neuropathological changes in rats with repeated sub-concussive impacts over 2 weeks

Bailey Hiles-Murison
Andrew P. Lavender
Ryu Takechi
ResearchOpen Access29 Apr 2021
Scientific Reports

Volume: 11, P: 1-12
The Comparison of Single Serum Antibody Values Against B. pertussis, C. pneumoniae, and M. pneumoniae Antigens in Active Duty American Soldiers in Korea Who Had Prolonged Cough Illnesses (Cases) with Similar Antibody Values in Sera from Well Active Duty Soldiers in Hawaii (Controls)

Judy M Vincent
William F Nauschwetz
James D Cherry
Research01 Apr 1999
Pediatric Research

Volume: 45, P: 177
Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2

Garry Cutting and colleagues report a genome-wide association and linkage study for loci that affect lung disease severity in cystic fibrosis. They identify two loci that influence lung function in individuals with cystic fibrosis.

Fred A Wright
Lisa J Strug
Garry R Cutting
Research22 May 2011
Nature Genetics

Volume: 43, P: 539-546
Heritable DNA methylation marks associated with susceptibility to breast cancer

DNA methylation is associated with breast cancer risk. Here the authors measure DNA methylation in the blood of individuals from 25 Australian families with multiple cases of breast cancer but not known mutations associated with breast cancer risk to identify possible heritable methylation markers.

Jihoon E. Joo
James G. Dowty
Yoland Antill
ResearchOpen Access28 Feb 2018
Nature Communications

Volume: 9, P: 1-12
Mendelian randomisation study of smoking exposure in relation to breast cancer risk

Hanla A. Park
Sonja Neumeyer
Jenny Chang-Claude
ResearchOpen Access02 Aug 2021
British Journal of Cancer

Volume: 125, P: 1135-1145
Ca²⁺ signaling during vertebrate somitogenesis

Sarah E Webb
Andrew L Miller
Reviews01 Jul 2006
Acta Pharmacologica Sinica

Volume: 27, P: 781-790
X‐chromosome-wide association study for Alzheimer’s disease

Julie Le Borgne
Lissette Gomez
Céline Bellenguez
ResearchOpen Access04 Dec 2024
Molecular Psychiatry

Volume: 30, P: 2335-2346
FANCM missense variants and breast cancer risk: a case-control association study of 75,156 European women

Gisella Figlioli
Amandine Billaud
Paolo Peterlongo
ResearchOpen Access27 Jan 2023
European Journal of Human Genetics

Volume: 31, P: 578-587
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3

Ian PM Tomlinson
Emily Webb
Richard S Houlston
Research30 Mar 2008
Nature Genetics

Volume: 40, P: 623-630
The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Gisella Figlioli
Massimo Bogliolo
Paolo Peterlongo
ResearchOpen Access01 Nov 2019
npj Breast Cancer

Volume: 5, P: 1-14
Manifestations of Alzheimer’s disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90

Laura Heath
John C. Earls
Yi Zhao
ResearchOpen Access12 Apr 2022
Scientific Reports

Volume: 12, P: 1-17
Targeting Enterococcus faecalis HMG-CoA reductase with a non-statin inhibitor

High-throughput in vitro screening and crystal structures identify a non-statin inhibitor of HMG-CoA reductase for novel antibacterial drug design.

Sucharita Bose
C. Nicklaus Steussy
Cynthia V. Stauffacher
ResearchOpen Access03 Apr 2023
Communications Biology

Volume: 6, P: 1-13
Oral ibandronate reduces the risk of skeletal complications in breast cancer patients with metastatic bone disease: results from two randomised, placebo-controlled phase III studies

J J Body
I J Diel
B Bergstrom
ResearchOpen Access24 Feb 2004
British Journal of Cancer

Volume: 90, P: 1133-1137
Homologous recombination DNA repair defects in PALB2-associated breast cancers

Anqi Li
Felipe C. Geyer
Mary Anne Young
ResearchOpen Access08 Aug 2019
npj Breast Cancer

Volume: 5, P: 1-14
Development and validation of a targeted gene sequencing panel for application to disparate cancers

Mark J. McCabe
Marie-Emilie A. Gauthier
Mary-Anne Young
ResearchOpen Access19 Nov 2019
Scientific Reports

Volume: 9, P: 1-16
Pediatric SARS-CoV-2 long term outcomes study (PECOS): cross sectional analysis at baseline

Gina A. Montealegre Sanchez
Lauren E. Arrigoni
Roberta L. DeBiasi
ResearchOpen Access18 Dec 2024
Pediatric Research

Volume: 98, P: 541-550
Alzheimer's Therapeutics: Translation of Preclinical Science to Clinical Drug Development

Alena V Savonenko
Tatiana Melnikova
Don L Price
Reviews21 Sept 2011
Neuropsychopharmacology

Volume: 37, P: 261-277
Zoledronic acid significantly improves pain scores and quality of life in breast cancer patients with bone metastases: a randomised, crossover study of community vs hospital bisphosphonate administration

A Wardley
N Davidson
D Cameron
ResearchOpen Access03 May 2005
British Journal of Cancer

Volume: 92, P: 1869-1876
Apoptotic cell death in disease—Current understanding of the NCCD 2023

Ilio Vitale
Federico Pietrocola
Lorenzo Galluzzi
Reviews26 Apr 2023
Cell Death & Differentiation

Volume: 30, P: 1097-1154
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Lorenzo Galluzzi
Ilio Vitale
Guido Kroemer
ReviewsOpen Access23 Jan 2018
Cell Death & Differentiation

Volume: 25, P: 486-541
Wild-type APC predicts poor prognosis in microsatellite-stable proximal colon cancer

Robert N Jorissen
Michael Christie
Oliver M Sieber
ResearchOpen Access25 Aug 2015
British Journal of Cancer

Volume: 113, P: 979-988
Publisher Correction: Homologous recombination DNA repair defects in PALB2-associated breast cancers

Anqi Li
Felipe C. Geyer
Jorge S. Reis-Filho
Amendments and CorrectionsOpen Access19 Nov 2019
npj Breast Cancer

Volume: 5, P: 1

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