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Showing 1–50 of 66 results

Advanced filters: Author: Antonio C. Wolff Clear advanced filters

A benchmark of expert-level academic questions to assess AI capabilities

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Long Phan
Alice Gatti
Davide Scaramuzza
ResearchOpen Access28 Jan 2026
Nature

Volume: 649, P: 1139-1146
Intrathecal onasemnogene abeparvovec in treatment-naive patients with spinal muscular atrophy: a phase 3, randomized controlled trial

The phase 3 STEER trial showed that a single intrathecal dose of onasemnogene abeparvovec significantly improved motor function in children and adolescents with spinal muscular atrophy versus sham, with a similar and acceptable safety profile.

Crystal M. Proud
Dũng Chí Vũ
Yuh-Jyh Jong
ResearchOpen Access08 Dec 2025
Nature Medicine

P: 1-7
Designing perturbative metamaterials from discrete models

A perturbative method is proposed for the systematic design of mechanical metamaterials, where each element of the discrete model is associated with individual geometric features of the metamaterial, through the weak interaction between the unit cells.

Kathryn H. Matlack
Marc Serra-Garcia
Chiara Daraio
Research15 Jan 2018
Nature Materials

Volume: 17, P: 323-328
L-DOPA: Effect on Ethanol Narcosis and Brain Biogenic Amines in Mice

K. BLUM
W. CALHOUN
J. E. WALLACE
Research06 Apr 1973
Nature

Volume: 242, P: 407-409
Xq–Yq interchange resulting in supernormal X-linked gene expression in severely retarded males with 46,XYq- karyotype

Bruce T. Lahn
Nancy Ma
David C. Page
Research01 Nov 1994
Nature Genetics

Volume: 8, P: 243-250
Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

On the electrocardiogram, the PR interval reflects conduction from the atria to ventricles and also serves as risk indicator of cardiovascular morbidity and mortality. Here, the authors perform genome-wide meta-analyses for PR interval in multiple ancestries and identify 141 previously unreported genetic loci.

Ioanna Ntalla
Lu-Chen Weng
Patricia B. Munroe
ResearchOpen Access21 May 2020
Nature Communications

Volume: 11, P: 1-12
Unforeseen plant phenotypic diversity in a dry and grazed world

Analysis of 20 chemical and morphological plant traits at diverse sites across 6 continents shows that the transition from semi-arid to arid zones is associated with an unexpected 88% increase in trait diversity.

Nicolas Gross
Fernando T. Maestre
Yoann Le Bagousse-Pinguet
Research07 Aug 2024
Nature

Volume: 632, P: 808-814
Infographic: SPECTRUM: study design of the global real-world study of aflibercept 8 mg in the treatment of neovascular age-related macular degeneration and diabetic macular edema

Clare Bailey
Clemens Lange
Vasileios Konidaris
ResearchOpen Access16 Jan 2026
Eye

P: 1-4
Comparative efficacy of a hydroxyapatite and a fluoride toothpaste for prevention and remineralization of dental caries in children

Bennett T. Amaechi
Parveez Ahamed AbdulAzees
Veronica Evans
ResearchOpen Access09 Dec 2019
BDJ Open

Volume: 5, P: 1-9
Regulation of local GTP availability controls RAC1 activity and cell invasion

Changes in intracellular GTP levels are not considered as a regulatory event in RAC1 activation in live cells since total GTP levels are substantially higher than the RAC1 GTP dissociation constant determined in vitro. Here, the authors demonstrate that the availability of free GTP in live cells controls the activity of RAC1 and cell invasion.

Anna Bianchi-Smiraglia
David W. Wolff
Mikhail A. Nikiforov
ResearchOpen Access19 Oct 2021
Nature Communications

Volume: 12, P: 1-15
p38γ/δ activation alters cardiac electrical activity and predisposes to ventricular arrhythmia

Romero-Becerra et al. report that stress kinases p38γ and p38δ are activated in ventricles of old mice and in arrhythmogenic conditions, and they demonstrate that p38γ/δ -driven phosphorylation of RyR2 and SAP97 is a trigger for ventricular fibrillation.

Rafael Romero-Becerra
Francisco M. Cruz
Guadalupe Sabio
Research27 Nov 2023
Nature Cardiovascular Research

Volume: 2, P: 1204-1220
Remineralization of molar incisor hypomineralization (MIH) with a hydroxyapatite toothpaste: an in-situ study

Bennett Tochukwu Amaechi
Rayane Farah
Joachim Enax
ResearchOpen Access10 Dec 2022
BDJ Open

Volume: 8, P: 1-10
Environment induced dynamical quantum phase transitions in two-qubit Rabi model

Dynamical quantum phase transitions can be observed when time is treated as a control parameter in non-equilibrium quantum systems. The authors show that quenching the qubits-oscillator coupling in a dissipative two-qubit system leads to different transitions depending on interactions and entanglement, with promising applications in quantum sensing and metrology.

Grazia Di Bello
Andrea Ponticelli
Carmine Antonio Perroni
ResearchOpen Access07 Nov 2024
Communications Physics

Volume: 7, P: 1-11
Sequence, structure, receptor-binding domains and internal repeats of human apolipoprotein B-100

Chao-Yuh Yang
San-Hwan Chen
Lawrence Chan
Research23 Oct 1986
Nature

Volume: 323, P: 738-742
GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture

Genome-wide association meta-analyses identify 26 risk loci for epilepsy, including 19 loci specific to genetic generalized epilepsy. Prioritized candidate genes implicate synaptic processes and overlap with targets of antiseizure medications.

Remi Stevelink
Ciarán Campbell
Quratulain Zulfiqar Ali
ResearchOpen Access31 Aug 2023
Nature Genetics

Volume: 55, P: 1471-1482
Allogeneic bone marrow transplantation in patients who relapse after autologous transplantation

T Tsai
S Goodman
CO Freytes
Research01 Nov 1997
Bone Marrow Transplantation

Volume: 20, P: 859-863
International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

Post-traumatic stress disorder (PTSD) is a common mental health problem. Here, the authors report a GWAS from the Psychiatric Genomics Consortium in which they identify two risk loci in European ancestry and one locus in African ancestry individuals and find that PTSD is genetically correlated with several other psychiatric traits.

Caroline M. Nievergelt
Adam X. Maihofer
Karestan C. Koenen
ResearchOpen Access08 Oct 2019
Nature Communications

Volume: 10, P: 1-16
Exome sequencing of 20,979 individuals with epilepsy reveals shared and distinct ultra-rare genetic risk across disorder subtypes

In this largest whole-exome sequencing study of epilepsies to date, the Epi25 Collaborative identified extremely rare variants that confer risk for diverse epilepsy subtypes, highlighting roles in synaptic transmission and neuronal excitability.

Siwei Chen
Bassel W. Abou-Khalil
Samuel F. Berkovic
Research03 Oct 2024
Nature Neuroscience

Volume: 27, P: 1864-1879
Observation of electroweak production of two jets and a Z-boson pair

The ATLAS Collaboration reports the observation of the electroweak production of two jets and a Z-boson pair. This process is related to vector-boson scattering and allows the nature of electroweak symmetry breaking to be probed.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access09 Feb 2023
Nature Physics

Volume: 19, P: 237-253
Hydrops fetalis—trends in associated diagnoses and mortality from 1997–2018

Veeral N. Tolia
R. Hunter Clark Jr.
Reese H. Clark
Research12 Aug 2021
Journal of Perinatology

Volume: 41, P: 2537-2543
Lumpectomy without radiation for ductal carcinoma in situ of the breast: 20-year results from the ECOG-ACRIN E5194 study

Jean L. Wright
Robert Gray
Antonio C. Wolff
ResearchOpen Access24 Feb 2024
npj Breast Cancer

Volume: 10, P: 1-6
197 ECHOCARDIOGRAPHIC FINDINGS IN CEREBRAL ARTERIOVENOUS MALFORMATIONS (AVM)

Mark Sivakoff
Soraya Nouri
Antonio Hernandez
Research01 Apr 1981
Pediatric Research

Volume: 15, P: 472
Author Correction: Palaeoclimate constraints on the impact of 2 °C anthropogenic warming and beyond

Hubertus Fischer
Katrin J. Meissner
Liping Zhou
Amendments and Corrections18 Jul 2018
Nature Geoscience

Volume: 11, P: 615
Inflammatory cytokines and distant recurrence in HER2-negative early breast cancer

Joseph A. Sparano
Anne O’Neill
Kathy D. Miller
ResearchOpen Access08 Feb 2022
npj Breast Cancer

Volume: 8, P: 1-6
Evidence for light-by-light scattering in heavy-ion collisions with the ATLAS detector at the LHC

Quantum electrodynamics predicts a rare process in which light is scattered by light. The ATLAS Collaboration reports signs of this elusive effect in the collisions of ultra-relativistic lead ions.

M. Aaboud
G. Aad
L. Zwalinski
ResearchOpen Access14 Aug 2017
Nature Physics

Volume: 13, P: 852-858
Genome-wide identification and phenotypic characterization of seizure-associated copy number variations in 741,075 individuals

Here, the authors perform a meta-analysis in 26,699 people with seizures and 492,324 controls to identify 25 genome-wide significant copy-number variants. The discovered loci point to known disease genes and associations with clinical annotations.

Ludovica Montanucci
David Lewis-Smith
Dennis Lal
ResearchOpen Access20 Jul 2023
Nature Communications

Volume: 14, P: 1-19
A biomaterial with a channel-like pore architecture induces endochondral healing of bone defects

A bioengineering approach to enhance the regeneration of large bone defects is lacking. Here, the authors show that a biomaterial scaffold with a channel-like pore architecture enables organized endochondral ossification through directional cell recruitment and extracellular matrix alignment.

A. Petersen
A. Princ
G. N. Duda
ResearchOpen Access25 Oct 2018
Nature Communications

Volume: 9, P: 1-16
Comparative study of the two more frequent HFE mutations (C282Y and H63D): significant different allelic frequencies between the North and South of Portugal

Carla S Cardoso
Pedro Oliveira
Maria de Sousa
Research11 Dec 2001
European Journal of Human Genetics

Volume: 9, P: 843-848
Axial penile rigidity as primary efficacy outcome during multi-institutional in-office dose titration clinical trials with alprostadil alfadex in patients with erectile dysfunction

I Goldstein
S Auerbach
L Schmitt
Research10 Oct 2000
International Journal of Impotence Research

Volume: 12, P: 205-211
‘Real-life’ report on the management of chronic GvHD in the Gruppo Italiano Trapianto Midollo Osseo (GITMO)

L Giaccone
G Mancini
A Olivieri
Research30 Oct 2017
Bone Marrow Transplantation

Volume: 53, P: 58-63
Bariatric surgery and bone disease: from clinical perspective to molecular insights

F Folli
B N Sabowitz
G Muscogiuri
Reviews17 Jul 2012
International Journal of Obesity

Volume: 36, P: 1373-1379
Monitoring bone changes due to calcium, magnesium, and phosphorus loss in rat femurs using Quantitative Ultrasound

Aldo Fontes-Pereira
Paulo Rosa
Wagner Coelho de Albuquerque Pereira
ResearchOpen Access10 Aug 2018
Scientific Reports

Volume: 8, P: 1-9
Eight glacial cycles from an Antarctic ice core

Laurent Augustin
Carlo Barbante
Mario Zucchelli
Research10 Jun 2004
Nature

Volume: 429, P: 623-628
Cardiac outcomes of subjects on adjuvant trastuzumab emtansine vs paclitaxel in combination with trastuzumab for stage I HER2-positive breast cancer (ATEMPT) study (TBCRC033): a randomized controlled trial

Romualdo Barroso-Sousa
Paolo Tarantino
Sara M. Tolaney
ResearchOpen Access16 Feb 2022
npj Breast Cancer

Volume: 8, P: 1-7
Multiomics in primary and metastatic breast tumors from the AURORA US network finds microenvironment and epigenetic drivers of metastasis

Perou and colleagues perform genomic, transcriptomic and epigenetic analyses on pairs of primary and metastatic breast tumors, detecting subtype switching and changes in immune signatures and DNA methylation patterns associated with metastasis.

Susana Garcia-Recio
Toshinori Hinoue
Charles M. Perou
ResearchOpen Access30 Dec 2022
Nature Cancer

Volume: 4, P: 128-147
Fluconazole vs low-dose amphotericin B for the prevention of fungal infections in patients undergoing bone marrow transplantation: a study of the North American Marrow Transplant Group

SN Wolff
J Fay
S Dummer
Research03 Apr 2000
Bone Marrow Transplantation

Volume: 25, P: 853-859
β-catenin knockdown promotes NHERF1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy

Concetta Saponaro
Sara Sergio
Addolorata Maria Luce Coluccia
ResearchOpen Access19 Mar 2018
Oncogene

Volume: 37, P: 3301-3316
Synecology of Lagoecia cuminoides L. in Italy and evaluation of functional compounds presence in its water or hydroalcoholic extracts

Enrico V. Perrino
Zuhair N. A. Mahmoud
Antonio Trani
ResearchOpen Access27 Nov 2023
Scientific Reports

Volume: 13, P: 1-15
A randomized intervention involving family to improve communication in breast cancer care

Jennifer L. Wolff
Jennifer Aufill
Antonio C. Wolff
ResearchOpen Access12 Feb 2021
npj Breast Cancer

Volume: 7, P: 1-9
Comparison of hydroxyapatite and fluoride oral care gels for remineralization of initial caries: a pH-cycling study

Bennett T. Amaechi
Parveez Ahamed AbdulAzees
Joachim Enax
ResearchOpen Access22 Jul 2020
BDJ Open

Volume: 6, P: 1-7
Primary results of the brazilian registry of atherothrombotic disease (NEAT)

Pedro G. M. de Barros e Silva
Charlene Troiani do Nascimento
Mauricio Antonio Pompilio
ResearchOpen Access20 Feb 2024
Scientific Reports

Volume: 14, P: 1-10
Palaeoclimate constraints on the impact of 2 °C anthropogenic warming and beyond

A review of Earth system changes associated with past warmer climates provides constraints on the environmental changes that could occur under warming of 2 °C or more over pre-industrial temperatures.

Hubertus Fischer
Katrin J. Meissner
Liping Zhou
Reviews25 Jun 2018
Nature Geoscience

Volume: 11, P: 474-485
Impact of a toothpaste with microcrystalline hydroxyapatite on the occurrence of early childhood caries: a 1-year randomized clinical trial

Elzbieta Paszynska
Malgorzata Pawinska
Elzbieta Luczaj-Cepowicz
ResearchOpen Access29 Jan 2021
Scientific Reports

Volume: 11, P: 1-15
A MT-TL1 variant identified by whole exome sequencing in an individual with intellectual disability, epilepsy, and spastic tetraparesis

Elke de Boer
Charlotte W. Ockeloen
Lisenka E. L. M. Vissers
ResearchOpen Access01 Jun 2021
European Journal of Human Genetics

Volume: 29, P: 1359-1368
Association of treatment-emergent symptoms identified by patient-reported outcomes with adjuvant endocrine therapy discontinuation

Karen Lisa Smith
Neha Verma
Vered Stearns
ResearchOpen Access21 Apr 2022
npj Breast Cancer

Volume: 8, P: 1-13
Apoptosis of the mammalian retina and lens

David S Papermaster
Reviews01 Jan 1997
Cell Death & Differentiation

Volume: 4, P: 21-28
Rendering the European neutron research landscape

Evgenii Velichko
Hartmut Abele
Marco Zanatta
ResearchOpen Access17 Feb 2025
Scientific Reports

Volume: 15, P: 1-11
Boosting SARS-CoV-2 detection combining pooling and multiplex strategies

Isadora Alonso Correa
Tamires de Souza Rodrigues
Antonio Augusto Fidalgo-Neto
ResearchOpen Access23 May 2022
Scientific Reports

Volume: 12, P: 1-11
The RB-related gene Rb2/p130 in neuroblastoma differentiation and in B-myb promoter down-regulation

Giuseppe Raschellà
Barbara Tanno
Marco G Paggi
Research15 May 1998
Cell Death & Differentiation

Volume: 5, P: 401-407
DNA methylation markers predict recurrence-free interval in triple-negative breast cancer

Mary Jo Fackler
Soonweng Cho
Christopher B. Umbricht
ResearchOpen Access31 Jan 2020
npj Breast Cancer

Volume: 6, P: 1-6

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