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Showing 1–14 of 14 results
Advanced filters: Author: Anurag Sethi Clear advanced filters

  • The genetic contribution to risk of Diffuse Idiopathic Skeletal Hyperostosis has been unclear. Here, the authors find genetic variation associated with Diffuse Idiopathic Skeletal Hyperostosis, finding phenotypic and genetic association with increased bone mass throughout the skeletal system.

    • Anurag Sethi
    • J. Graham Ruby
    • Eugene Melamud
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • The Pharma Proteomics Project generates the largest open-access plasma proteomics dataset to date, offering insights into trans protein quantitative trait loci across multiple biological domains, and highlighting genetic influences on ligand–receptor interactions and pathway perturbations across a diverse collection of cytokines and complement networks.

    • Benjamin B. Sun
    • Joshua Chiou
    • Christopher D. Whelan
    ResearchOpen Access
    Nature
    Volume: 622, P: 329-338

  • ENCODE is a resource comprising thousands of functional genomic datasets. Here, the authors present custom annotation within ENCODE for cancer, highlighting a workflow that can help prioritise key elements in oncogenesis.

    • Jing Zhang
    • Donghoon Lee
    • Mark Gerstein
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • A diverse, multidisciplinary panel of 386 experts in COVID-19 response from 112 countries provides health and social policy actions to address inadequacies in the pandemic response and help to bring this public health threat to an end.

    • Jeffrey V. Lazarus
    • Diana Romero
    • Anne Øvrehus
    ResearchOpen Access
    Nature
    Volume: 611, P: 332-345

  • A genome-wide association study including over 76,000 individuals with schizophrenia and over 243,000 control individuals identifies common variant associations at 287 genomic loci, and further fine-mapping analyses highlight the importance of genes involved in synaptic processes.

    • Vassily Trubetskoy
    • Antonio F. Pardiñas
    • Jim van Os
    Research
    Nature
    Volume: 604, P: 502-508

  • The authors summarize the data produced by phase III of the Encyclopedia of DNA Elements (ENCODE) project, a resource for better understanding of the human and mouse genomes.

    • Federico Abascal
    • Reyes Acosta
    • Zhiping Weng
    ResearchOpen Access
    Nature
    Volume: 583, P: 699-710

  • Wang M. et al. leverage machine learning analysis of UK Biobank DXA scans, revealing aging related changes in spinal curvature (both kyphosis and lordosis) associated with decreased muscle mass and bone density. Genome-wide association reveals genetic risk factors related to musculoskeletal function are associated with age-related spinal curvature.

    • Frances M. Wang
    • J. Graham Ruby
    • Eugene Melamud
    ResearchOpen Access
    Communications Medicine
    Volume: 5, P: 1-14

  • Uniform processing and detailed annotation of human, worm and fly RNA-sequencing data reveal ancient, conserved features of the transcriptome, shared co-expression modules (many enriched in developmental genes), matched expression patterns across development and similar extent of non-canonical, non-coding transcription; furthermore, the data are used to create a single, universal model to predict gene-expression levels for all three organisms from chromatin features at the promoter.

    • Mark B. Gerstein
    • Joel Rozowsky
    • Robert Waterston
    ResearchOpen Access
    Nature
    Volume: 512, P: 445-448

  • The authors summarize the history of the ENCODE Project, the achievements of ENCODE 1 and ENCODE 2, and how the new data generated and analysed in ENCODE 3 complement the previous phases.

    • Federico Abascal
    • Reyes Acosta
    • Richard M. Myers
    Reviews
    Nature
    Volume: 583, P: 693-698