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Advanced filters: Author: Aoife Tang Clear advanced filters

A controllable human spinal cord model with full dorsoventral patterning

The authors developed a microfluidic human stem cell model of the embryonic spinal cord. The model mimics complete dorsoventral patterning, reveals new retinoic acid-BMP signaling crosstalk, and enables direct tracking of neural crest cell migration.

Jeyoon Bok
Yung Su Kim
Jianping Fu
ResearchOpen Access28 Mar 2026
Nature Communications

P: 1-17
Generation of spatially patterned human neural tube-like structures using microfluidic gradient devices

Protocol for generating spatially patterned, human neural tube- and forebrain-like structures, by using a microfluidic device to impose orthogonal and independent chemical gradients on human pluripotent stem cells.

Xufeng Xue
Omar M. Rahman
Jianping Fu
Protocols08 Oct 2025
Nature Protocols

Volume: 21, P: 1730-1753

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A controllable human spinal cord model with full dorsoventral patterning

Generation of spatially patterned human neural tube-like structures using microfluidic gradient devices

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