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Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

An improved ligand-exchange process allows the realization of solution-deposited films of quantum dots with reduced energetic disorder and, as a result, solar cells with improved open-circuit voltage, charge-carrier transport and stability.

Lipid nanoparticles (LNPs) delivering mRNA after intratumoral administration could be a promising cancer treatment strategy. Here this group reports the intratumoral delivery of mRNA with LNPs inducing the expression of purine nucleoside phosphorylase and inhibiting the progression of head and neck squamous cell carcinoma in vivo.

Photophysical and photochemical features of graphene quantum dots (GQDs) strongly depend on their chemical nature that remains challenging to be controlled in a systematic and uniform manner. Here the authors report an efficient solvent-catalyst-aided growth of chemically tailored N-doped GQDs.

Current approaches for the delivery of CRISPR systems into cells can be hampered by several limitations, including low delivery potential and inefficient genome editing. Here, the authors present Droplet Cell Pincher (DCP), a gene delivery system that combines droplet microfluidics with cell mechanoporation, which attains efficient genome engineering.

SARS-CoV-2 induces mild infection in ferret model. Here, Ryan et al. characterise optimal infection dosage inducing upper respiratory tract (UTR) viral shedding, progression time of viral shedding, and pathology in ferrets and finally provide evidence for protection after re-challenge.

A lipid nanoparticle is used to deliver mRNA to hematopoietic stem cells in macaques.

Understanding the intricate relationship between alloying elements and oxidation processes is essential for the integrity and performance of materials. Here, the authors study the effects of atomic size and redox potential to understand the oxidation process and structural changes in surface oxides.

Fas-associated protein with death domain (FADD) is part of a signalling complex that controls some forms of programmed cell death. Lee and colleagues demonstrate that FADD ubiquitination by the E3 ubiquitin ligase MKRN1 regulates FADD protein stability and thereby cell death.

Glutathione has pleiotropic functions in different organs. Here the authors specifically examine deletion of a glutathione synthetic enzyme in the liver of adult mice and show that lack of glutathione affects lipid abundance through repressing NRF2.

Silica formation in diatoms is of interest for a range of different subjects from biomimetics to oceanography. Here the authors study the formation of silicified extensions in diatoms and find that unlike cell wall elements, that form in the cytoplasm, the extensions have a different formation mechanism outside the cytoplasm.

Desymmetrization of symmetric biaryls is an efficient but underexplored way to approach axially chiral molecules. Here, the authors report the atroposelective desymmetrization of 2- arylresorcinols via chiral palladium complex-catalyzed allylic alkylation.

AMPK activation has been suggested as treatment for obesity and its complications. Here the authors show that the ubiquitin ligase MKRN1 binds to AMPK and mediates its ubiquitination and degradation. Loss of MKRN1 leads to AMPK activation, increased glucose consumption and decreased lipid accumulation.

Achieving atomic control during the synthesis of heterogeneous catalysts remains challenging. Here the authors tackle this challenge by applying a liquid-phase atomic layer deposition approach to the synthesis of Cu/ZrO_x clusters on MgO as efficient catalysts for CO₂ hydrogenation to methanol.

Proteins that sample multiple conformations in the absence of a ligand have been presumed to operate via a conformational selection mechanism. Single molecule FRET studies of maltose binding protein now cast doubts on that assumption.

A co-adsorbent is used to achieve a uniform self-assembled phosphonic acid monolayer on a textured substrate, leading to more efficient inverted perovskite solar cells.

This study identifies a fundamental link between slow-moving ions inside grains and fast-moving ions along grain boundaries in metal halide perovskites that governs their environmental stability and current–voltage responses.

An international team of researchers finds high potential for improving climate projections by a more comprehensive treatment of largely ignored Arctic vegetation types, underscoring the importance of Arctic energy exchange measuring stations.

Studies on the morphology stability of polymer donor–small-molecule acceptor blends relevant to solar cell stability reveal relationships between their intermolecular interactions and the thermodynamic, kinetic, thermal and mechanical properties.

Towards further integration and miniaturization of e-textiles, in this work, authors demonstrate an integrated electronic fibre platform by fabricating multiple electronic components such as transistors, inverters, ring oscillators, and thermocouples onto the outer surface of a microfibre substrate.

G protein-coupled receptors APLNR and CXCR4 are crucial for vascular development. Here, the authors show that these two signaling pathways communicate and that in response to blood flow APLNR signaling induces a decrease in CXCR4 expression via miR-139-5p, thereby restricting CXCR4 expression to the non-flow exposed tip cells in the retinal vasculature.

Tissue-specific transcriptional activity is silenced in mitotic cells. Here the authors reveal a general phosphorylation-dependent mechanism of recognition for the anaphase-promoting complex (APC) substrates, and show that the APC targets ID2 during the establishment of post-mitotic transcription.

Mutations and post-translational modifications of the PI3K/AKT pathway inhibitor PTEN are a feature of many cancers, but these have not been associated with cervical cancer. Here, the authors identify a PI3K/AKT-mediated ubiquitination degradation pathway of PTEN that occurs in patients with cervical cancer.

Waterlogging threatens global crop production, yet it remains under-represented in agricultural impact assessments and crop models. This Review examines 21 crop models, identifying limitations in how they simulate waterlogging and coupled soil–crop processes. It also proposes pathways to enhance model accuracy for better agricultural adaptation and management.

A systematic analysis is performed to reveal how deposition conditions and the use of cations and solvents affect the composition and orientation of 2D and quasi-2D metal halide perovskites in thin films.

Winter warming in the Arctic will increase the CO₂ flux from soils. A pan-Arctic analysis shows a current loss of 1,662 TgC per year over the winter, exceeding estimated carbon uptake in the growing season; projections suggest a 17% increase under RCP 4.5 and a 41% increase under RCP 8.5 by 2100.

The copper nanofibrils are formed at the void inside the long continuous carbon nanotube (CNT) fiber by electroplating. Electrical conduction through the composite fiber was dominated by the nanofibrils even though their cross-sectional area is much smaller than that of CNTs. The nanofibrils could carry a very high current density due to their bamboo-like structure and the thermal dissipation through CNTs.