Xanthine oxidase (XO) inhibition by febuxostat, rather than the effect of lowering hyperuricemia, may have directly contributed to the improvement of arterial stiffness in the present study. Plausible explanations of this beneficial effect are proposed as the counter action via XO inhibition to macrophage adventitial infiltration, vascular cell hypertrophy, and proliferation of vascular smooth muscle cell and vascular wall connective tissues or endothelial dysfunction.
- Kazuki Shiina
- Hirofumi Tomiyama
- Koichi Node
