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Robust antibiotic sensitization of pathogenic Pseudomonas aeruginosa via negative hysteresis in the cell envelope

Here, the authors describe negative hysteresis as a phenomenon where the initial exposure of Pseudomonas aeruginosa to β-lactam antibiotics causes cellular sensitization towards aminoglycoside antibiotics.

Florian Buchholz
Lina M. Upterworth
Hinrich Schulenburg
ResearchOpen Access26 Mar 2026
Nature Communications

P: 1-16
Lysophosphatidylcholines are associated with amyloidosis in early stages of Alzheimer’s disease

Kalia et al. investigate metabolic changes in Alzheimer’s disease (AD) using blood metabolomics, and show that lysophosphatidylcholines are associated with early amyloidosis in AD as measured by P-tau181 and P-tau217.

Vrinda Kalia
Dolly Reyes-Dumeyer
Badri N. Vardarajan
ResearchOpen Access17 Dec 2025
Nature Aging

Volume: 6, P: 221-234
Structural features discriminating hybrid histidine kinase Rec domains from response regulator homologs

Bacterial multi-step phospho-relays employ receiver domains that act as intermediaries in phosphoryl shuttling. Here, the authors show that such a domain does not experience structural changes upon pseudo-phosphorylation, in contrast to the well-studied homologs in response regulators.

Mitchell Brüderlin
Raphael Böhm
Badri N. Dubey
ResearchOpen Access02 Mar 2023
Nature Communications

Volume: 14, P: 1-15
Reciprocal growth control by competitive binding of nucleotide second messengers to a metabolic switch in Caulobacter crescentus

Crosstalk between small-molecule regulated networks controls growth in Caulobacter crescentus.

Viktoriya Shyp
Badri Nath Dubey
Urs Jenal
Research09 Nov 2020
Nature Microbiology

Volume: 6, P: 59-72
Precise timing of transcription by c-di-GMP coordinates cell cycle and morphogenesis in Caulobacter

Bacteria adapt their growth rate to their metabolic status and environmental conditions by modulating the length of their G1 period. Here the authors show that an increase in c-di-GMP concentration modulates the activity of kinase ShkA and transcription factor TacA, thus enabling G1/S transition in Caulobacter.

Andreas Kaczmarczyk
Antje M. Hempel
Urs Jenal
ResearchOpen Access10 Feb 2020
Nature Communications

Volume: 11, P: 1-16
Mutant structure of metabolic switch protein in complex with monomeric c-di-GMP reveals a potential mechanism of protein-mediated ligand dimerization

Badri Nath Dubey
Viktoriya Shyp
Tilman Schirmer
ResearchOpen Access21 Feb 2023
Scientific Reports

Volume: 13, P: 1-13

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Robust antibiotic sensitization of pathogenic Pseudomonas aeruginosa via negative hysteresis in the cell envelope

Lysophosphatidylcholines are associated with amyloidosis in early stages of Alzheimer’s disease

Structural features discriminating hybrid histidine kinase Rec domains from response regulator homologs

Reciprocal growth control by competitive binding of nucleotide second messengers to a metabolic switch in Caulobacter crescentus

Precise timing of transcription by c-di-GMP coordinates cell cycle and morphogenesis in Caulobacter

Mutant structure of metabolic switch protein in complex with monomeric c-di-GMP reveals a potential mechanism of protein-mediated ligand dimerization

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Robust antibiotic sensitization of pathogenic Pseudomonas aeruginosa via negative hysteresis in the cell envelope

Lysophosphatidylcholines are associated with amyloidosis in early stages of Alzheimer’s disease

Structural features discriminating hybrid histidine kinase Rec domains from response regulator homologs

Reciprocal growth control by competitive binding of nucleotide second messengers to a metabolic switch in Caulobacter crescentus

Precise timing of transcription by c-di-GMP coordinates cell cycle and morphogenesis in Caulobacter

Mutant structure of metabolic switch protein in complex with monomeric c-di-GMP reveals a potential mechanism of protein-mediated ligand dimerization

Search

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