Search

Genome-wide association meta-analysis identifies 58 independent risk loci for major anxiety disorders among individuals of European ancestry and implicates GABAergic signaling as a potential mechanism underlying genetic risk for these disorders.

V2P predicts variant pathogenicity conditioned on disease phenotypes across top-level Human Phenotype Ontology categories. This approach shows promise for phenotype-specific estimation of variant effect and may be applied to single nucleotide variants and small insertions/deletions throughout the genome.

Spatial transcriptomics technologies are still too restrictive for widespread clinical use, and methods that have been designed to bridge them with histopathology carry important limitations. Here, the authors develop MISO, a deep learning framework that allows inferring tissue spatial organisation and gene expression with near single-cell resolution from histopathology images.

Sepsis induces a period of immunosuppression which can be problematic in the face of subsequent infectious challenge. Here the authors show the presence of PD-L1 expressing regulatory plasma cells that can inhibit T cells in a murine model and in patients with sepsis.

Neural mechanisms underlying state-dependent flexible selection are not fully understood. Here authors show that NPY homologues in Drosophila larva differentially modulate reciprocally connected inhibitory neurons to bias non-feeding decisions, favoring escape-type actions (Head Cast), over protective-type actions (Hunch), in response to a mechanical cue.

Phage–host interactions are computationally predicted using only genomic information, highlighting future research directions and enabling generation of custom phage cocktails.

External Control Arm methods for clinical trials were developed to compare the efficacy of a treatment to a control group that is built with data from external sources. Here, the authors present FedECA, a privacy-enhancing method for analyzing treatment effects across institutions, streamlining multi-centric trial design and thereby accelerating drug development while minimizing patient data exposure.

A spinal cord neuroprosthesis targeting leg motor neurons in real time improves walking and reduces freezing of gait in non-human primate models and in one individual with advanced Parkinson’s disease.

Combined analysis of new genomic data from 116 ancient hunter-gatherer individuals together with previously published data provides insights into the genetic structure and demographic shifts of west Eurasian forager populations over a period of 30,000 years.

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Multidrug-resistant pathogens have become increasingly common in hospital settings. Here, the authors investigate the efficacy of adjunctive antibiotic and phage therapy in a human cell model and a murine model of ventilator-associated pneumonia.

Although functional interactions between receptors shape brain cell communication, their direct interaction remains elusive. Here, authors monitor the weak and transient interaction between NMDA and dopamine receptors, which tune synaptogenesis.

The percentage of national populations infected during the first stages of the COVID-19 pandemic are unclear owing to limited early testing. Here the authors provide a nation-wide prevalence study of SARS-CoV-2 antibodies in France from the first wave of COVID-19 in 2020, including stratification based on age, sex and region.

Here, the authors show the emergence of valley-polarized Floquet-Bloch states in 2H-WSe₂ upon below-band-gap driving using circularly polarized light.

BIN1/M-Amphiphysin2 is a membrane tubulating protein involved in muscle T-tubule biogenesis and whose loss-of-function is associated with centronuclear myopathies. Picas et al.show that BIN1 enhances the recruitment of its binding partner, dynamin, by clustering PtdIns(4,5)P2 in the plasma membrane.

Combined intraocular injection of an adeno-associated viral vector, encoding an optogenetic sensor, with light stimulation via engineered goggles enables partial recovery of visual function in a blind patient.

Thioredoxin 1 (TrxA) is an enzyme that reduces disulfide bonds in the bacterial cytosol. Here, the AUs show that TrxA can function as a chaperone of the secreted bacterial ADP-ribosyltransferase toxin TreX independent of redox catalysis.

Cohort-scale integration of clinical and proteomic data from tumor tissues in patients with pancreatic ductal adenocarcinoma led to the identification of a prognostic risk model for patient stratification as well as biomarkers of response to adjuvant chemotherapy, validated in independent external cohorts.

Different proteins localised at telomeres ensure chromosome end stability to prevent double strand-end break recognition. Here the authors provide new insight into how in S. cerevisiae the interaction between Rif2 and Rad50 inhibits MRX functions at telomeres.

Saturn's rotation period was initially determined to be 10h 39m 24s ± 7s, based on long-wavelength radio emission. But subsequent observations revealed that this period varies by ± 6 min on a timescale of several months to years. It is shown that the periodicity of the radio waves varies systematically by ±1 percent with a characteristic timescale of 20–30 days, and it is demonstrated that these fluctuations are correlated with solar wind speed at Saturn.

Mineral dust and marine sediment resuspension are generally considered the primary sources of the nutrient iron to the oceans. Numerical model results suggest that iron released by hydrothermal activity is also an important source of dissolved iron, particularly in the Southern Ocean.

The authors find that calcium signaling triggers liquid–liquid phase separation of CaMKII. This reorganizes the postsynaptic structure, acting as a potential mechanism to increase the efficacy of synaptic transmission during memory formation.

PRMT2 is a key regulator of inflammation in acute myeloid leukemia. PRMT2-deficient cells exhibit a pro-inflammatory profile associated with STAT3 activation.

Blockade of the C5a–C5aR1 axis using anti-C5aR1 monoclonal antibodies prevented inflammation associated with COVID-19.

The size and spatial distribution of pits on comet 67P/Churyumov–Gerasimenko, which are active and probably created by a sinkhole process, imply that large heterogeneities exist in the physical, structural or compositional properties of the first few hundred metres below the current cometary surface.

Knowledge of fundamental properties of lead halide perovskites is crucial for their technological development. Here, authors perform magneto-optical spectroscopy, develop universal scaling laws and offer a predictive picture for interaction energies within photo-generated charge-carrier complexes.

Postzygotic inactivating mutations in RHOA cause a mosaic neuroectodermal syndrome characterized by linear hypopigmentation, leukoencephalopathy and craniofacial anomalies, highlighting the role of RHOA in human development and disease.

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

When the Philae lander bounced on the surface of comet 67P/Churyumov–Gerasimenko, it exposed primitive icy-dust material within cometary boulders; the intrinsic strength and porosity of this material is reported.