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Achieving supported nanoclusters with unique geometric and electronic structures continues to pose a challenge. Here, the authors introduce a plasma-assisted treatment approach for generating supported metal oxide nanoclusters, facilitated by the rapid transformation of monomeric dispersed metal oxides.

Stretchable and self-healing light-emitting capacitors operating at low frequency and low voltage have been realized using a transparent elastomeric dielectric with high permittivity.

Heavy pnictogen-based compounds are promising nontoxic and stable alternatives to lead-halide perovskites, but are limited by carrier localization. Here, by investigating CuSbSe₂, the authors identify how this limitation could be avoided.

Bandit optimization models are used to identify generally applicable conditions by efficient condition sampling and evaluation of experimental feedback.

Persisting symptoms after concussion (PSaC) present a complex neuropsychiatric challenge with limited treatment options due to inconsistent neuroimaging findings. Here the authors employ a multi-analytic approach to identify the salience network as a core dysfunction hub in PSaC, proposing specific cortical regions as potential targets for personalized neuromodulation therapies.

Gouldian finches have a head colour polymorphism that is also associated with physiological and behavioural differentiation. Here, the authors map this colour polymorphism to a putative regulatory region for follistatin on the Z chromosome and suggest it is maintained by balancing selection.

Surface chemistry controls the location of WSe₂ nucleation on a stepped sapphire substrate. Preferential nucleation at either the top or bottom step edge can be used to minimize mirror twin domains and produce unidirectional WSe₂ monolayers.

Actinium-225 is a promising isotope for α-therapy but progress in developing its chemistry is hindered by its high radioactivity and short supply. Here, the authors characterize actinium coordination in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory.

At the hybrid interface between an organic molecular layer and a metallic magnetic surface, spin-filtering effects may be exploited for the generation of spin polarization. Here, the authors demonstrate a dynamic spin-filtering effect across the Co/Alq₃ interface, mediated via a second Alq₃layer.

Chips with 256 × 256 memristor arrays that were monolithically integrated on complementary metal–oxide–semiconductor (CMOS) circuits in a commercial foundry achieved 2,048 conductance levels in individual memristors.

Many topological crystalline phases have unknown physical responses. Here, the authors systematically extend the theory of defect and flux responses to predict zero-dimensional (0D) states in topological crystalline materials, including 2D PbTe monolayers and 3D SnTe.

Californium is difficult to prepare in its divalent state. Now, crystals of a Cf(II) crown–ether complex have been synthesized by reduction of a Cf(III) precursor with an Al/Hg amalgam. They exhibit 5f→6d transitions in the visible region and near-infrared emission that are highly sensitive to changes in the coordination environment.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Large genome-wide meta-analysis of clinically diagnosed late-onset Alzheimer’s disease (LOAD) from 94,437 individuals identifies new LOAD risk loci and implicates Aβ formation, tau protein binding, immune response and lipid metabolism.

Iridium oxide is the state-of-the-art catalyst for water oxidation in an acidic electrolyte. Now amorphous and crystalline iridium oxides are studied using operando time-resolved optical spectroscopy, together with other techniques, to reveal the nature and density of active centres and the role of adsorbate–adsorbate interactions.

Microscopic colitis is a chronic inflammatory disease of the large intestine. Here the authors use single-cell RNA transcriptomic profiling and tissue localization studies to characterise the colon immune cell populations in MC, showing expansion of CD8 T cells with diverse TCR clonotypes and expression of CD4 T reg cell signatures.

PtRu nanoparticles are the state-of-the-art catalysts for methanol electrooxidation—the anodic reaction in direct methanol fuel cells. Now, a method of dispersing single Pt atoms over Ru nanoparticles is presented and monitored in situ, thereby boosting the catalytic performance in the methanol oxidation reaction.

Heart failure is a major cause of cardiovascular morbidity and mortality. Here, the authors report results of a genome-wide association study meta-analysis, characterizing the role of common genetic variants in heart failure, finding overlap with common cardiovascular risk factors and imaging measures of cardiac structure/function.

Experimental measurements of high-order out-of-time-order correlators on a superconducting quantum processor show that these correlators remain highly sensitive to the quantum many-body dynamics in quantum computers at long timescales.

Nanometre-sized clusters can self-organize into centimetre-scale hierarchical structures, mimicking the complex constructions seen in nature and providing a platform to design synthetically directed advanced materials with sophisticated functions.

H₂ generated from water electrolysis is a promising, carbon-neutral fuel, but sluggish oxidation kinetics and poor catalyst stability in acid limits the chemistry. Here, authors prepare solid-solution catalysts based on ruthenium-chromium oxides that are stable and active for acidic water oxidation.

Integrating electrocatalytic H₂ production with biological H₂-fed systems for CO₂ upgrading requires H₂ generation to occur in biocompatible media—typically with neutral pH. Here, the authors design multi-site H₂ evolution catalysts that minimize the water dissociation barrier and promote hydride coupling in neutral media.

Two-dimensional zeolite MFI nanosheets show ultra-selective separation of xylene isomers, but it was not known why this occurs. Here, using electron microscopy and atomistic simulation, it is shown that one-dimensional intergrowths of zeolite MEL enable selectivity by formation of more rigid pores.

This Review details the use of enantioenriched organometallic nucleophiles in stereospecific, Pd-catalysed cross-coupling reactions. Particular focus is placed on the stereochemical outcome of the coupling reactions, which enable the predictable manipulation of 3D molecular structure.

In coordination and organometallic chemistry, back-bonding between an electron-rich, typically mid- or low-oxidation-state d-block metal centre and a ligand with accepting π* orbitals is widespread. Now, such an interaction has been observed between unlikely partners—high-oxidation-state uranium(v) 5f¹ ion and the poor π-acceptor ligand dinitrogen—in a U(v)–bis(imido)–N₂ complex stabilized by a lithium counterion.

Sodium ion batteries could be an attractive alternative to Li-ion technology but designing high energy density and moisture stable Na-based cathodes is challenging. Adjusting synthesis conditions and stoichiometry, an O3-type NaLi_1/3Mn_2/3O₂ phase with anionic redox activity is reported.

Monolayer transition-metal dichalcogenide (TMD) is promising to host features of topological superconductivity. Here, de la Barrera et al. study layered compounds, 2H-TaS₂ and 2H-NbSe₂, in their atomic layer limit and find a largest upper critical field for an intrinsic TMD superconductor.

An investigation using various methods reports an association between adeno-associated virus 2 and paediatric hepatitis of unknown aetiology.

Single-cell transcriptomics and in vivo challenge models establish a key role for the aryl hydrocarbon receptor in regulating the function of enteric endothelial cells in response to environmental cues.

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

Fishing has had a profound impact on global reef shark populations, and the absence or presence of sharks is strongly correlated with national socio-economic conditions and reef governance.

Exome-sequencing analyses of a large cohort of patients with type 2 diabetes and control individuals without diabetes from five ancestries are used to identify gene-level associations of rare variants that are associated with type 2 diabetes.

Two halting mechanisms, ‘walk-OFF’ and ‘brake’, are shown to be engaged by distinct neural circuits in Drosophila, in a context dependent manner.

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Hybrid organic-inorganic perovskites are emerging materials for efficient photovoltaics; however understanding how charge/heat dissipates inside the material remains a challenge. Here, the authors use a spectroscopic approach to observe unusually slow thermal equilibration between the organic and inorganic components.

Mesocrystal formation is investigated for haematite in the presence of oxalate, showing that chemical gradients at interfaces cause nucleation near surfaces rather than in the bulk, followed by particle attachment.

Jung et al. show that shelter experience boosts dopamine release in the nucleus accumbens, generating a goal-location memory. Reactivating a neuronal ensemble developed from shelter experience enables memory-guided navigation to the goal during escape.

Compared to monovalent lithium or sodium ions, the reversible insertion of multivalent ions into battery electrodes has proved challenging. An aliovalent doping strategy involving reversible Mg²⁺ and Al³⁺ insertion in anatase TiO₂ is now reported.

Analysis of whole-genome sequencing data across 2,658 tumors spanning 38 cancer types shows that chromothripsis is pervasive, with a frequency of more than 50% in several cancer types, contributing to oncogene amplification, gene inactivation and cancer genome evolution.

Analysis of mitochondrial genomes (mtDNA) by using whole-genome sequencing data from 2,658 cancer samples across 38 cancer types identifies hypermutated mtDNA cases, frequent somatic nuclear transfer of mtDNA and high variability of mtDNA copy number in many cancers.

Efficient, large-scale genomic analysis is facilitated on the cloud by a computational tool with error-diagnosing and self-healing capabilities.

Progesterone receptor membrane component 2 is required to transport haem from the mitochondria to the nucleus, where, in adipose tissue, it has roles in regulation of thermogenesis and glucose metabolism.

Antibody mediated immunity to SARS-CoV-2 will affect future transmission and disease severity. This systematic review on antibody response to coronaviruses, including SARS-CoV-2, SARS-CoV, MERS-CoV and endemic coronaviruses provides insights into kinetics, correlates of protection, and association with disease severity.

The extent of antibody protection against SARS-CoV-2 remains unclear. Here, using a cohort of 120 seroconverted individuals, the authors longitudinally characterize neutralization, Fc-function, and SARS-CoV-2 specific T cell responses, which they show to be prominent only in those subjects that elicited receptor-binding domain (RBD)-specific antibody titers above a certain threshold, suggesting that development of T cell responses to be related to anti-RBD Ab production.

Riboswitches can mediate ligand-dependent RNA cleavage and splicing to control gene expression. Here the authors present a method to functionally screen large libraries and identify functional variants.

Chandelier cells organize neural coding and mediate learning by establishing inhibitory circuit motifs over individual pyramidal neurons and suppressing irrelevant activity via adaptive axo-axonic synaptic plasticity, subserving efficient computation.