Nature Search

Validation of the 4B5 rabbit monoclonal antibody in determining Her2/neu status in breast cancer

Bert van der Vegt
Geertruida H de Bock
Jelle Wesseling
Research20 Mar 2009
Modern Pathology

Volume: 22, P: 879-886
Intraoperative fluorescence-guided fresh frozen sectioning for margin control in head and neck cancer: phase 2 clinical trial

Tumour- free margins at initial surgery are associated with beneficial outcomes in head and neck cancer patients and could reduce the need for adjuvant therapy, thus decreasing patient morbidity. In here, the authors show that tumour-targeting fluorescent tracer cetuximab-IRDye800CW can be used to guide fresh frozen sectioning to identify inadequate margins intraoperatively.

Thomas S. Nijboer
Bas Keizers
Floris J. Voskuil
ResearchOpen Access10 Mar 2026
Nature Communications

P: 1-9
EGFR-targeted fluorescence molecular imaging for intraoperative margin assessment in oral cancer patients: a phase II trial

By using tumor-specific fluorescent tracers, fluorescence molecular imaging (FMI) can be used to visualize tumor tissues with high specificity. Here the authors report the results of a phase II trial to evaluate the diagnostic accuracy of an EGFR-targeted FMI for intraoperative margin assessment in patients with oral squamous cell carcinoma.

Jaron G. de Wit
Jasper Vonk
Max J. H. Witjes
ResearchOpen Access16 Aug 2023
Nature Communications

Volume: 14, P: 1-10
cGAS–STING drives the IL-6-dependent survival of chromosomally instable cancers

The survival of cells with chromosomal instability (CIN) depends on the cGAS–STING pathway, in which IL-6 and its receptor have a key role; this vulnerability can be exploited to treat tumours that display CIN.

Christy Hong
Michael Schubert
Floris Foijer
Research15 Jun 2022
Nature

Volume: 607, P: 366-373
Compatibility of fast tissue clearing with targeted fluorescence imaging and pathology analysis using clinical head and neck cancer biopsies

Ali Fakhrolmobasheri
Thomas S. Nijboer
Pieter J. van der Zaag
ResearchOpen Access23 Nov 2025
Scientific Reports

Volume: 15, P: 1-12
Implementation and benchmarking of a novel analytical framework to clinically evaluate tumor-specific fluorescent tracers

Fluorescent tracers are being tested in clinical trials to improve detection of tumor margins, but procedures are not standardised. Here, the authors develop an analytical framework that is compatible with the workflow in the operating theatre, and show that it leads to an 88% increase in intraoperative detection of tumor margins in patients with breast cancer.

Marjory Koller
Si-Qi Qiu
Gooitzen M. van Dam
ResearchOpen Access18 Sept 2018
Nature Communications

Volume: 9, P: 1-11
cGAS-STING pathway expression correlates with genomic instability and immune cell infiltration in breast cancer

Mengting Chen
Shibo Yu
Marcel A. T. M. van Vugt
ResearchOpen Access02 Jan 2024
npj Breast Cancer

Volume: 10, P: 1-13
Systematically higher Ki67 scores on core biopsy samples compared to corresponding resection specimen in breast cancer: a multi-operator and multi-institutional study

Balazs Acs
Samuel C. Y. Leung
Inti Zlobec
ResearchOpen Access21 Jun 2022
Modern Pathology

Volume: 35, P: 1362-1369
Intraoperative imaging in pathology-assisted surgery

This Perspective describes current clinical standards for intraoperative tissue analysis in oncology and discusses potential clinical implementations of intraoperative imaging for pathology-assisted surgery.

Floris J. Voskuil
Jasper Vonk
Gooitzen M. van Dam
Reviews08 Nov 2021
Nature Biomedical Engineering

Volume: 6, P: 503-514
Aggressiveness of ‘true’ interval invasive ductal carcinomas of the breast in postmenopausal women

Bert van der Vegt
Jelle Wesseling
Geertruida H de Bock
Research15 Jan 2010
Modern Pathology

Volume: 23, P: 629-636
Cyclin E expression is associated with high levels of replication stress in triple-negative breast cancer

Sergi Guerrero Llobet
Bert van der Vegt
Marcel A. T. M. van Vugt
ResearchOpen Access07 Sept 2020
npj Breast Cancer

Volume: 6, P: 1-13
Chronic kidney disease and incident cancer risk: an individual participant data meta-analysis

Yejin Mok
Aditya Surapaneni
Michael G. Shlipak
ResearchOpen Access06 Sept 2025
British Journal of Cancer

Volume: 133, P: 1535-1543
An mRNA expression-based signature for oncogene-induced replication-stress

Sergi Guerrero Llobet
Arkajyoti Bhattacharya
Marcel A. T. M. van Vugt
Research29 Jan 2022
Oncogene

Volume: 41, P: 1216-1224

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