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Single-cell multiomics uncovers an endothelial mechanosensitive PIEZO1-IL-33 axis driving pulmonary fibrosis

Pulmonary fibrosis is a progressive lung disease characterized by scarring and impaired function, with vascular endothelial cells playing a key role in disease progression. Here, the authors show that endothelial mechanosensitive PIEZO1 promotes fibrosis by activating the CAPN2-STAT3-IL-33 signaling axis, identifying a promising therapeutic target for treatment.

Lanlan Zhang
Xuezhen Gui
Shanze Chen
ResearchOpen Access20 Mar 2026
Nature Communications

Volume: 17, P: 1-17
Publisher Correction: Histone variant H3.3 maintains adult haematopoietic stem cell homeostasis by enforcing chromatin adaptability

Peipei Guo
Ying Liu
Shahin Rafii
Amendments and Corrections20 Jan 2022
Nature Cell Biology

Volume: 24, P: 279
Platelets prime hematopoietic–vascular niche to drive angiocrine-mediated liver regeneration

Koji Shido
Deebly Chavez
Bi-Sen Ding
ResearchOpen Access17 Feb 2017
Signal Transduction and Targeted Therapy

Volume: 2, P: 1-9
MLKL PARylation in the endothelial niche triggers angiocrine necroptosis to evade cancer immunosurveillance and chemotherapy

Yang, Li, Huang, Ji, Luo, Jiang and colleagues report that chemotherapy induces MLKL PARylation and necroptosis in tumour endothelial cells, which in turn affects tumour-associated macrophages and CD8⁺ T cells, promoting immunosuppression and tumorigenesis.

Nan Yang
Xiaoxue Li
Zhongwei Cao
Research05 Sept 2025
Nature Cell Biology

Volume: 27, P: 1526-1542
Platelet-derived SDF-1 primes the pulmonary capillary vascular niche to drive lung alveolar regeneration

Ding and colleagues report that blood platelets recruited to the lung by injury release the chemokine SDF-1, which interacts with its receptor CXCR4 on pulmonary capillary endothelial cells and thereby initiates alveolar regeneration.

Shahin Rafii
Zhongwei Cao
Bi-Sen Ding
Research26 Jan 2015
Nature Cell Biology

Volume: 17, P: 123-136
The Aging Biomarker Consortium represents a new era for aging research in China

Jie Ren
Moshi Song
Guang-Hui Liu
Correspondence19 Jul 2023
Nature Medicine

Volume: 29, P: 2162-2165
Histone variant H3.3 maintains adult haematopoietic stem cell homeostasis by enforcing chromatin adaptability

Guo et al. show that H3.3 prevents the premature exhaustion of HSCs and differentiation into granulocyte-macrophage progenitors by safeguarding the interplay between H3K27me3 and H3K9me3 marks.

Peipei Guo
Ying Liu
Shahin Rafii
Research27 Dec 2021
Nature Cell Biology

Volume: 24, P: 99-111
Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis

Divergent angiocrine signals from liver sinusoidal endothelial cells elicit regeneration after immediate injury and provoke fibrosis after chronic insult.

Bi-Sen Ding
Zhongwei Cao
Shahin Rafii
Research20 Nov 2013
Nature

Volume: 505, P: 97-102
Aging breaks liver vascular ‘zone defense’

Wang Lin and his colleagues explore how aging reprograms spatially unique pathways in liver endothelial cells to cause fibrosis. They find that loss of KIT in liver endothelial cells close to the central vein upregulates the chemokine receptor CXCR4 to stimulate inflammation, enhance fibrosis and increase lipid accumulation in aged liver.

Zhongwei Cao
Bi-Sen Ding
News & Views20 Feb 2023
Nature Aging

Volume: 3, P: 242-243
Testicular endothelial cells are a critical population in the germline stem cell niche

Self-renewal of spermatogonial stem cells (SSC) is necessary for spermatogenesis and male fertility. Here the authors identify testicular endothelial cells (TECs) as a source of 5 key growth factors for self-renewal and expansion of human and mouse SSCs.

Dong Ha Bhang
Bang-Jin Kim
Sandra Ryeom
ResearchOpen Access22 Oct 2018
Nature Communications

Volume: 9, P: 1-16
Targeting of the pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis

Pulmonary fibrosis induced by repetitive chemical injury in mice involves cross talk among macrophages, endothelial cells and fibroblasts. Macrophages induce expression of the Notch ligand Jag1 in pulmonary capillary endothelial cells, leading to Notch pathway activation in perivascular fibroblasts and fibrosis.

Zhongwei Cao
Raphael Lis
Bi-Sen Ding
Research18 Jan 2016
Nature Medicine

Volume: 22, P: 154-162
Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells

Endothelial cells form a vascular niche that supports haematopoietic stem cell function. Akt activation in endothelial cells upregulates angiocrine factors to promote long-term haematopoietic stem cell repopulation capacity while co-activation of Akt and MAPK shift the balance towards maintenance and differentiation of their progenitors.

Hideki Kobayashi
Jason M. Butler
Shahin Rafii
Research24 Oct 2010
Nature Cell Biology

Volume: 12, P: 1046-1056
Deciphering the molecular mechanism of the bacterial division motor TolQRA

Chongrong Shen
Teng Xie
Haohao Dong
ResearchOpen Access04 Nov 2025
Cell Discovery

Volume: 11, P: 1-12
Biomarkers of ageing of humans and non-human primates

The use of biomarkers of ageing is crucial for investigating age-related processes. This Review discusses biomarkers of ageing and of ageing-associated physiological changes, at the cellular, tissue and organism levels in humans and non-human primates.

Zeming Wu
Jing Qu
Guang-Hui Liu
Reviews11 Sept 2025
Nature Reviews Molecular Cell Biology

Volume: 26, P: 826-847
Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration

These authors describe a molecular pathway by which endothelial cells sustain liver regeneration after surgical resection. Activation of vascular endothelial growth factor-A receptor-2 in a defined subpopulation of liver endothelial cells leads to the upregulation of the endothelial-specific transcription factor Id1, which in turn induces Wnt2 and hepatocyte growth factor, which are secreted from the endothelial cells and trigger hepatocyte proliferation.

Bi-Sen Ding
Daniel J. Nolan
Shahin Rafii
Research10 Nov 2010
Nature

Volume: 468, P: 310-315
Deciphering the molecular basis of lipoprotein recognition and transport by LolCDE

Wen Qiao
Chongrong Shen
Haohao Dong
ResearchOpen Access27 Dec 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-12
Angiocrine functions of organ-specific endothelial cells

Shahin Rafii
Jason M. Butler
Bi-Sen Ding
Reviews20 Jan 2016
Nature

Volume: 529, P: 316-325
Structural insights into the activation of the divisome complex FtsWIQLB

Lili Yang
Yujiao Chen
Xiaodi Tang
CorrespondenceOpen Access03 Jan 2024
Cell Discovery

Volume: 10, P: 1-4

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