Cell cycle regulation of the two major DNA double-strand break repair pathways—NHEJ and HR—is critical for the maintenance of genome integrity. Here, Tomimatsu et al. show that phosphorylation of the nuclease EXO1 by cyclin-dependent kinases affects repair pathway choice by controlling long-range resection.
- Nozomi Tomimatsu
- Bipasha Mukherjee
- Sandeep Burma
