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Nature Immunology (2)

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Advanced filters: Author: Bishan Bhattarai Clear advanced filters

Circadian circuits control plasticity of group 3 innate lymphoid cells by sustaining epigenetic configuration of RORγt

Colonna and colleagues show that the clock genes encoding REV-ERBα and REV-ERBβ maintain ILC3 functions in the gut by controlling the expression of RORγt.

Bishan Bhattarai
Alina Ulezko Antonova
Marco Colonna
Research13 Aug 2025
Nature Immunology

Volume: 26, P: 1527-1539
Enhancing human NK cell antitumor function by knocking out SMAD4 to counteract TGFβ and activin A suppression

The authors show that knocking out SMAD4, human NK cells resist TGFβ and activin A suppression and demonstrate that SMAD4 knockout enhances the antitumor function of several NK cell products in clinical development.

Anna Rea
Sara Santana-Hernández
Aura Muntasell
ResearchOpen Access21 Mar 2025
Nature Immunology

Volume: 26, P: 582-594

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Circadian circuits control plasticity of group 3 innate lymphoid cells by sustaining epigenetic configuration of RORγt

Enhancing human NK cell antitumor function by knocking out SMAD4 to counteract TGFβ and activin A suppression

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