Nature Search

Glucagon-like peptide-1 receptor agonist in large vessel occlusion treated by reperfusion therapy—a phase 2 randomized trial

Semaglutide, a GLP-1 receptor agonist, may offer neuroprotective benefits after stroke, but its effects in large vessel occlusion (LVO) are unknown. Here the authors show, in a phase 2 randomized trial, that semaglutide is safe after endovascular therapy and may improve recovery in patients not receiving intravenous thrombolysis.

Hao Wang
Ho Ko
Bonaventure Y. Ip
ResearchOpen Access14 Dec 2025
Nature Communications

Volume: 16, P: 1-10
Sterol-C4-methyl-oxidase Erg251 governs Candida albicans hypoxic growth, commensalism and virulence

Candida albicans must adapt to hypoxia. Here, the authors discover the sterol C4-methyl oxidase (SMO) Erg251 is essential for extreme hypoxic growth, as well as virulence and colonization, and that SMO inhibitors have therapeutic potential.

Zhongle Liu
Bonnie Yiu
Leah E. Cowen
ResearchOpen Access12 Dec 2025
Nature Communications

Volume: 16, P: 1-17
An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease

This study finds that sST2 is a disease-causing factor for Alzheimer’s disease. Higher sST2 levels impair microglial Aβ clearance in APOE4⁺ female individuals. A genetic variant, rs1921622, is associated with a reduction in sST2 level and protects against AD in APOE4⁺ female individuals.

Yuanbing Jiang
Xiaopu Zhou
Nancy Y. Ip
ResearchOpen Access15 Jul 2022
Nature Aging

Volume: 2, P: 616-634
Distinct genetic pathways define pre-malignant versus compensatory clonal hematopoiesis in Shwachman-Diamond syndrome

Understanding the molecular basis of leukaemia predisposition is essential for intervention. The authors here investigate germline genetic leukaemia predisposition by studying Shwachman-Diamond syndrome and report compensatory inactivating mutations in EIF6 and transforming biallelic TP53 alterations.

Alyssa L. Kennedy
Kasiani C. Myers
R. Coleman Lindsley
ResearchOpen Access26 Feb 2021
Nature Communications

Volume: 12, P: 1-15
Intrinsic immunogenicity is a major determinant of type-specific responses in SARS-CoV-2 infections

Bhattacharya and colleagues assess the impact of antigenic imprinting using samples from mRNA vaccinated or unvaccinated individuals primarily infected with the SARS-CoV-2 variants Delta and Omicron BA.1.

Grace E. Quirk
Marta V. Schoenle
Deepta Bhattacharya
Research27 May 2025
Nature Immunology

Volume: 26, P: 829-836
Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma

Chiea Chuen Khor, Tin Aung and colleagues report the results of a large genome-wide association study of primary angle closure glaucoma. They identify five new susceptibility loci and provide insights into disease pathogenesis.

Chiea Chuen Khor
Tan Do
Tin Aung
Research04 Apr 2016
Nature Genetics

Volume: 48, P: 556-562
Indoor incense burning impacts cognitive functions and brain functional connectivity in community older adults

Adrian Wong
Wutao Lou
Vincent Chung-tong Mok
ResearchOpen Access27 Apr 2020
Scientific Reports

Volume: 10, P: 1-11
High burden of cerebral white matter lesion in 9 Asian cities

Bonnie Yin Ka Lam
Brian Yiu
Vincent Chung Tong Mok
ResearchOpen Access02 Jun 2021
Scientific Reports

Volume: 11, P: 1-12
Hedgehog/GLI1 activation leads to leukemic transformation of myelodysplastic syndrome in vivo and GLI1 inhibition results in antitumor activity

Bonnie W. Lau
Kyounghee Huh
Lukasz P. Gondek
Research31 Aug 2018
Oncogene

Volume: 38, P: 687-698
Redefining prognostication of de novo cytogenetically normal acute myeloid leukemia in young adults

Sze P. Tsui
Ho W. Ip
Anskar Y. Leung
CorrespondenceOpen Access19 Oct 2020
Blood Cancer Journal

Volume: 10, P: 1-5

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Glucagon-like peptide-1 receptor agonist in large vessel occlusion treated by reperfusion therapy—a phase 2 randomized trial

Sterol-C4-methyl-oxidase Erg251 governs Candida albicans hypoxic growth, commensalism and virulence

An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease

Distinct genetic pathways define pre-malignant versus compensatory clonal hematopoiesis in Shwachman-Diamond syndrome

Intrinsic immunogenicity is a major determinant of type-specific responses in SARS-CoV-2 infections

Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma

Indoor incense burning impacts cognitive functions and brain functional connectivity in community older adults

High burden of cerebral white matter lesion in 9 Asian cities

Hedgehog/GLI1 activation leads to leukemic transformation of myelodysplastic syndrome in vivo and GLI1 inhibition results in antitumor activity

Redefining prognostication of de novo cytogenetically normal acute myeloid leukemia in young adults

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