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Cystine levels in pancreatic ductal adenocarcinoma (PDAC) tumour microenvironment are deficient, despite its crucial role for cancer cell maintenance. Here, the authors show that adaptation to cystine limitation stress promotes PDAC growth through induces metabolic reprogramming to promote PDAC tumor growth, while conferring a vulnerability in lipid metabolism targetable by lomitapide.

The authors investigate how in vitro fertilization-derived mouse embryos differ from those obtained via natural mating and observe changes in the epigenetic and transcriptomic landscapes. They further show that CPI-455, inhibitor of the histone demethylase KDM5, may facilitate both human and mouse embryo development in vitro.

Soft robotic grippers still face challenges in delivering high force while gently handling fragile objects. Here, authors present a humanoid finger that combines rigid bones with soft silicone skin, connected by joint springs. The system demonstrates grasping capabilities from items like tofu to heavy objects.

Gate-all-around (GAA) nanosheet field-effect transistors (FETs) based on 2D semiconductors hold promise to complement silicon in future integrated circuits. Here, the authors report the wafer-scale growth of high-κ dielectric/semiconductor β-Bi₂SeO₅/Bi₂O₂Se/α-Bi₂SeO₅ heterostructures and their application for high performance 2D GAA FETs.

Vapour-phase methods are promising for nanomaterial synthesis but the vaporization of different precursors for the synthesis of a broad nanomaterial space is challenging. Here electrified vapour deposition generates ultrahigh-temperature, high-flux atomic vapour at atmospheric pressure to rapidly vaporize diverse precursors, enabling the synthesis of multi-elemental nanomaterials with uniform compositions and tunable structures.

Analysis of wheat lines generated through introgression or gene editing provides evidence that Fhb1-mediated resistance to Fusarium head blight is independent of the pore-forming toxin gene PFT.

Site-specific protein multi-conjugates are important for both scientific and translational research. Here, the authors genetically encode unnatural amino acids which contain both tetrazine and azide, and use the doubly bio-orthogonal handles to generate bi- and tri-conjugate proteins in high yields.

Fe–N–C catalysts are a promising alternative to precious metals in fuel cell cathodes, but they suffer from durability issues. Now, a preparation method is reported that allows increasing the active site density while also improving durability.

Dynamic behavior is typically observed in organic crystals and metal complexes, but is rarely found in hybrid halides. Here, the authors find a pressure-induced irreversible phase transition with remarkable shape and color changes in a 1D halide.

With the example of the paraspeckle protein PSPC1, Shao et al. demonstrated the synergistic interplay of promoter-associated RNA and its binding proteins in promoting transcription condensate formation and Pol II engagement and activity via phase separation.

Efficient charge separation plays a crucial role in enhancing artificial photocatalysis. Here, the authors report an alkali etching method to construct an electron transfer layer on BiVO₄:Mo photocatalysts, leading to a charge separation efficiency exceeding 90% at 420 nm.

HGSNAT is a critical lysosomal membrane enzyme involved in the devastating lysosomal storage disease Sanfilippo syndrome. Here, Zhao et. al. reveal the mechanism for transmembrane acetylation catalyzed by HGSNAT with a series of cryo-EM structures.

The comprehensive and quantitative mapping of pseudouridine (Ψ) sites across four plant species provides critical resources for plant Ψ research, and reveals multilayered translation regulation through rRNA, tRNA and mRNA pseudouridylation in plants.

Driving comfort in autonomous vehicles is crucial but often overlooked in global path planning. Here, authors developed a model using multi-head attention and XGBoost to predict driving comfort from road information, reducing jerk by 15% and improving comfort scores by 13% in real vehicle tests.

A cancer vaccine is delivered to the lung by an engineered attenuated influenza virus.

Iridium-based electrocatalysts are traditional anode catalysts for proton exchange membrane water electrolysis but suffer from high cost and low reserves. An alternative, nickel-stabilized ruthenium dioxide catalyst with high activity and durability in acidic oxygen evolution reaction for water electrolysis is reported.

Robust, high-throughput processing of two-dimensional materials produced by chemical vapor deposition requires a reliable and scalable technique to transfer the materials to a target substrate. An automated system for transferring chemical-vapor-deposited two-dimensional materials using robotics is developed, demonstrating high production capability with uniformity and repeatability of the transferred materials.

Chromatin-associated retrotransposon RNA 5-methylcytosine can be recognized by the methyl-CpG-binding-domain protein MBD6, which guides deubiquitination of nearby monoubiquitinated Lys119 of histone H2A to promote an open chromatin state in TET2-deficient cells.

Metal- and N-coordinated carbon materials are promising electrocatalysts, but improved activity and stability are desirable for fuel cell applications. Chang et al. address this by introducing F atoms into Pd/N–C catalysts, modifying the environment around the Pd and enhancing performance for ethanol oxidation and oxygen reduction.

CD47 blockade can trigger T cell-mediated destruction of immunogenic tumors. Here the authors show that, by reprograming tumor cell metabolism toward OXPHOS for ATP production, tumor cell-intrinsic type I IFN signaling is required for CD47-SIRPa blockade efficacy.

The authors profile single-base resolution maps at each modified mRNA m⁶A site in rice and Arabidopsis, and uncover a suppression-activation dual regulation model in shaping m⁶A distribution patterns in different species.

Here, the authors report a polymer-free transfer method to fabricate suspended 2D materials with high intactness and thermal conductivity, facilitating the application of graphene grids for high-resolution electron microscopy.

Reliable transfer techniques are critical for the integration of 2D materials with arbitrary substrates. Here, the authors describe a method to transfer 4-inch and A4-sized defect-free graphene films onto rigid and flexible substrates with controllable conformal contact, leading to improved electrical properties and uniformity.

Fe–N–C materials are promising oxygen reduction catalysts for proton-exchange membrane fuel cells but still lack sufficient long-term durability for practical applications. Here the authors fabricate an Fe–N–C material with a thin N–C layer on the surface, leading to a highly durable and active catalyst.

Dou, Xiao, Shen, Wang et al. show that RBFOX2 recognizes m⁶A on chromatin-associated RNAs and recruits RBM15, YTHDC1 and PRC2 to facilitate transcription suppression. Inhibition of the axis exerts anti-leukaemic effects.

Achieving artificial photosynthesis in open environments is highly challenging. Here, the authors present a composite of indium metal-organic framework and graphene oxide that efficiently reduces low-concentration CO₂ containing air-level O₂ while effectively removing contaminants from real water.

Orthogonally conjugating the cytokine interleukin-2 to poly(ethylene glycol) moieties at defined protein sites improves its pharmacokinetics and half-life as well as its therapeutic performance in mouse models of autoimmune diseases.

It is challenging to develop high-activity and durable catalysts for both ethanol oxidation reaction on the anode and oxygen reduction reaction on the cathode. Here in this work, authors proposed Pd/Co@N-C catalyst as a model to synergistically maximize the usage of catalyst nanoparticles and active interfaces for direct ethanol fuel cells.

Here, the authors determine the exciton polarizabilities for 3- to 11-layer black phosphorus via frequency-resolved photocurrent measurements on dual-gate devices, and unveil the exciton response for higher-index sub-bands under the gate electrical field, as well as a carrier screening effect in thicker samples.

High carbon dioxide pressure and calcium-rich additives increase carbonate formation in South China Sea seawater, which shows stronger buffering and saturation behavior than synthetic solutions, based on experiments and geochemical modeling.

Here authors use iDPC-STEM to directly image the rotation of linkers in MOFs, demonstrating an approach to study the local flexibility. They show that the dynamic properties of UiO-66-X are likely correlated to their macroscopic properties of CO₂ uptake.

In-depth mechanistic insights inform the fabrication of an all-solid-state, Co-free lithium battery with good performance and cyclability.

Platinum group metal- and iron-free catalysts are highly desirable for the oxygen reduction reaction in proton-exchange membrane fuel cells. Now, Wu and co-workers show a carbon catalyst with atomically dispersed single Mn sites as an efficient catalyst with enhanced stability in acidic media.

The amount of secondary organic aerosol produced from wildfire emissions is much higher than previously thought, according to model simulations of evolution of individual species of organic aerosol over time.

The largest whole-exome sequencing study of sporadic congenital hydrocephalus identities mutations associated with disrupted fetal neuro-gliogenesis as the primary pathophysiological event in a significant number of cases.

Whole-exome sequencing of 250 parent–offspring trios identifies an enrichment of rare damaging de novo mutations in individuals with cerebral palsy and implicates genetically mediated dysregulation of early neuronal connectivity in the etiology of this disorder.

Platinum-group-metal-free, non-iron catalysts are highly desirable for the oxygen reduction reaction at proton exchange membrane (PEM) fuel cell cathodes, as they avoid the detrimental Fenton reactions. Now, a cobalt and nitrogen co-doped carbon catalyst with atomically dispersed porphyrin-like CoN₄C₁₂ sites is reported with an improved activity and durability in PEM fuel cell conditions.

While temperature impacts the function of all cellular components, it’s hard to rule out how the temperature dependence of cell phenotypes emerged from the dependence of individual components. Here, the authors develop a Bayesian genome scale modelling approach to identify thermal determinants of yeast metabolism.

.Sensitive detection of weak acoustic signals at nanometer scale is challenging. Here, the authors present an acoustic detection system based on a single molecule as a probe, where frequency and amplitude of acoustic vibrations can be extracted from its minute variations in distance to the surface of a plasmonic gold nanorod.

Vein of Galen malformations (VOGMs) are severe congenital brain arteriovenous malformations. Here the authors work to elucidate the pathogenesis of VOGMs by performing an integrated analysis of 310 VOGM proband family exomes and 336,326 human cerebrovasculature single-cell transcriptomes to identify mutations of key signaling regulators.