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Cell Death and Differentiation (2)
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Showing 1–4 of 4 results

Advanced filters: Author: Bozhi Ye Clear advanced filters

Cardiomyocyte-derived USP13 protects hearts from hypertrophy via deubiquitinating and stabilizing STAT1 in male mice

Deubiquitinating enzymes play an essential role in myocardial hypertrophy. Here, the authors show the beneficial effects of a cardiomyocyte-derived deubiquitinating enzyme, USP13, in hypertrophic cardiomyocytes and identify a cardiomyocyte-specific USP13-STAT1 axis in regulating cardiac hypertrophy.

Jibo Han
Liming Lin
Yi Wang
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-16
Deubiquitinase JOSD2 improves calcium handling and attenuates cardiac hypertrophy and dysfunction by stabilizing SERCA2a in cardiomyocytes

Han, Fang et al. show that the deubiquitinase JOSD2 deubiquitinates and stabilizes SERCA2a in cardiomyocytes, which results in normalized calcium handling and reduced cardiac pathology under hypertensive stress.

Jibo Han
Zimin Fang
Guang Liang
Research07 Aug 2023
Nature Cardiovascular Research

Volume: 2, P: 764-777
USP25 directly interacts with and deubiquitinates PPARα to increase PPARα stability in hepatocytes and attenuate high-fat diet-induced MASLD in mice

Leiming Jin
Weiwei Zhu
Guang Liang
Research18 Jan 2025
Cell Death & Differentiation

Volume: 32, P: 1112-1127
USP13 ameliorates diabetic cardiomyopathy via deubiquitinating NLRP3 and inhibiting pyroptosis in cardiomyocytes

Diyun Xu
Jibo Han
Guang Liang
Research08 Nov 2025
Cell Death & Differentiation

P: 1-16

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