Nature Search

Induction chemo-immunotherapy followed by chemo-radiotherapy and immunotherapy maintenance in stage III NSCLC (APOLO): a phase 2 trial

Standard of care in patients with unresectable stage III non-small cell lung cancer (NSCLC) is concurrent chemo-radiotherapy followed by immunotherapy. Here, the authors report a phase II trial investigating induction chemo-immunotherapy (atezolizumab, carboplatin and paclitaxel) followed by concurrent chemoradiotherapy and immunotherapy maintenance in patients with stage III NSCLC.

Mariano Provencio
Begoña Campos
Alberto Cruz-Bermúdez
ResearchOpen Access23 Dec 2025
Nature Communications

Volume: 16, P: 1-9
The baryon density of the Universe from an improved rate of deuterium burning

High-precision cross-sections of the nuclear reaction that burns deuterium to create helium-3 are used to produce theoretical estimates of the primordial baryon density that are in agreement with recent astronomical observations.

V. Mossa
K. Stöckel
S. Zavatarelli
Research11 Nov 2020
Nature

Volume: 587, P: 210-213
Evidence of an upper ionospheric electric field perturbation correlated with a gamma ray burst

Gamma-ray bursts (GRBs) are known to have impact on Earth’s lower ionosphere, but GRB impacts on the upper ionosphere was not observed before. Here, the authors show strong electric field variation at 500 km in the ionosphere caused by GRB221009A.

Mirko Piersanti
Pietro Ubertini
Paolo Zuccon
ResearchOpen Access14 Nov 2023
Nature Communications

Volume: 14, P: 1-10
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
Origin of meteoritic stardust unveiled by a revised proton-capture rate of ¹⁷O

Isotopic analyses of stardust have yet to single out a specific stellar origin for it. A revision of the proton-capture rate of ¹⁷O has helped to identify intermediate mass stars (4–8 solar masses) as the source of a large fraction of meteoritic stardust.

M. Lugaro
A. I. Karakas
D. Trezzi
Research30 Jan 2017
Nature Astronomy

Volume: 1, P: 1-5
A dense ring of the trans-Neptunian object Quaoar outside its Roche limit

The authors report observations of a dense and inhomogeneous ring at a surprisingly large distance from the trans-Neptunian body Quaoar.

B. E. Morgado
B. Sicardy
J. de Wit
Research08 Feb 2023
Nature

Volume: 614, P: 239-243
Correction: Corrigendum: Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27–stimulated T cells

Denise C Fitzgerald
Guang-Xian Zhang
Abdolmohamad Rostami
Amendments and Corrections01 Jan 2008
Nature Immunology

Volume: 9, P: 105
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Large genome-wide meta-analysis of clinically diagnosed late-onset Alzheimer’s disease (LOAD) from 94,437 individuals identifies new LOAD risk loci and implicates Aβ formation, tau protein binding, immune response and lipid metabolism.

Brian W. Kunkle
Benjamin Grenier-Boley
Margaret A. Pericak-Vance
Research28 Feb 2019
Nature Genetics

Volume: 51, P: 414-430
Identification of candidate T-cell epitopes and molecular mimics in chronic Lyme disease

Bernhard Hemmer
Bruno Gran
Roland Martin
Research01 Dec 1999
Nature Medicine

Volume: 5, P: 1375-1382
Observation of two-neutrino double electron capture in ¹²⁴Xe with XENON1T

Two-neutrino double electron capture is observed experimentally in ¹²⁴Xe with the XENON1T detector, yielding a half-life of 1.8 × 10²² years.

E. Aprile
J. Aalbers
J. P. Zopounidis
Research24 Apr 2019
Nature

Volume: 568, P: 532-535
Mammals show faster recovery from capture and tagging in human-disturbed landscapes

In wildlife tagging, stress from capture and handling can alter post- release behavior and potentially study interpretations. This study of 42 mammal species shows that these effects diminish within 4–7 days, and quicker for animals in high human activity areas indicating adaptation to disturbance.

Jonas Stiegler
Cara A. Gallagher
Niels Blaum
ResearchOpen Access15 Sept 2024
Nature Communications

Volume: 15, P: 1-13
Sensitivity of South American tropical forests to an extreme climate anomaly

The authors analyse tree responses to an extreme heat and drought event across South America to understand long-term climate resistance. While no more sensitive to this than previous lesser events, forests in drier climates showed the greatest impacts and thus vulnerability to climate extremes.

Amy C. Bennett
Thaiane Rodrigues de Sousa
Oliver L. Phillips
ResearchOpen Access04 Sept 2023
Nature Climate Change

Volume: 13, P: 967-974
Towards primary prevention of multiple sclerosis

Multiple sclerosis is among the most common causes of disability in the young and its prevention is a feasible, albeit ambitious, goal. In this Perspective, Dobson et al. discuss the challenges in developing and testing preventive interventions in MS and propose strategies and solutions.

Ruth Dobson
Karim L. Kreft
Mark Leach
Reviews27 Nov 2025
Nature Reviews Neurology

P: 1-14
Multiple sclerosis-associated IL2RA polymorphism controls GM-CSF production in human T_H cells

Genetic studies have connected polymorphisms in the IL-2 receptor alpha (IL2RA) gene with susceptibility to multiple sclerosis, but the mechanisms underlying this association are not clear. Here, the authors show that a polymorphism in IL2RA increases responsiveness to IL-2 and GM-CSF production in human T_Hcells.

Felix J. Hartmann
Mohsen Khademi
Burkhard Becher
Research03 Oct 2014
Nature Communications

Volume: 5, P: 1-10
New insights into the genetic etiology of Alzheimer’s disease and related dementias

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

Céline Bellenguez
Fahri Küçükali
Jean-Charles Lambert
ResearchOpen Access04 Apr 2022
Nature Genetics

Volume: 54, P: 412-436
Robotica e InterAction Technology: il ruolo chiave dell'Italia nella prossima rivoluzione

Il piano nazionale di ripresa e resilienza trascura un campo di ricerca strategico in cui l'Italia ha un vantaggio competitivo

Antonio Bicchi
Bruno Siciliano
Comments & Opinion08 Oct 2021
Nature Italy
Autoimmune associations in multiple sclerosis

The growing literature on comorbidity in multiple sclerosis (MS)—in particular, the association of MS with other autoimmune diseases—provides interesting clues to the complex pathogenesis of this disease, but also raises awareness of the important issues that need to be considered in its management.

Cris S. Constantinescu
Bruno Gran
News & Views04 Nov 2010
Nature Reviews Neurology

Volume: 6, P: 591-592
Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27–stimulated T cells

Denise C Fitzgerald
Guang-Xian Zhang
Abdolmohamad Rostami
Research11 Nov 2007
Nature Immunology

Volume: 8, P: 1372-1379
Encephalitogenic potential of the myelin basic protein peptide (amino acids 83–99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand

Bibiana Bielekova
Bonnie Goodwin
Roland Martin
Research01 Oct 2000
Nature Medicine

Volume: 6, P: 1167-1175
A core outcome set for locoregional treatment reporting in neoadjuvant systemic breast cancer treatment trials

Shelley Potter
Kerry Avery
Anagha Zope
ResearchOpen Access28 Oct 2025
npj Breast Cancer

Volume: 11, P: 1-10
Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Contrary to the view that urbanization is a major driver of the global rise in obesity, the global increase in body-mass index is shown to be mostly due to increases in the body-mass indexes of rural populations.

Honor Bixby
James Bentham
Majid Ezzati
ResearchOpen Access08 May 2019
Nature

Volume: 569, P: 260-264
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
DarkSide-20k sensitivity to light dark matter particles

The DarkSide-20k collaboration reports the sensitivity of its detector, currently under construction, to models predicting light dark matter particles. This includes Weakly Interacting Massive Particles and particles interacting with bound electrons of argon atoms.

F. Acerbi
P. Adhikari
M. P. Zykova
ResearchOpen Access26 Dec 2024
Communications Physics

Volume: 7, P: 1-9
A peculiar low-luminosity short gamma-ray burst from a double neutron star merger progenitor

A short-duration gamma-ray burst was detected along with a double neutron start merger gravitational wave by LIGO-Virgo on August 17th 2017. Here, the authors show that the fluence and spectral peak energy of this event fall into the lower portion of the distribution of known short-duration gamma-ray bursts.

B.-B. Zhang
B. Zhang
E.-W. Liang
ResearchOpen Access31 Jan 2018
Nature Communications

Volume: 9, P: 1-6
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Sven van der Lee, Julie Williams, Gerard Schellenberg and colleagues identify rare coding variants in PLCG2, ABI3 and TREM2 associated with Alzheimer's disease. These genes are highly expressed in microglia and provide additional evidence that the microglia-mediated immune response contributes to the development of Alzheimer's disease.

Rebecca Sims
Sven J van der Lee
Gerard D Schellenberg
Research17 Jul 2017
Nature Genetics

Volume: 49, P: 1373-1384
Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Brian W. Kunkle
Benjamin Grenier-Boley
Margaret A. Pericak-Vance
Amendments and Corrections15 Aug 2019
Nature Genetics

Volume: 51, P: 1423-1424
Mid-term outcomes of percutaneous pulmonary valve replacement with Edwards-Sapien bioprosthesis in native right ventricular outflow tract

Yassin Belahnech
Gerard Martí-Aguasca
Ignacio Ferreira-González
ResearchOpen Access01 Feb 2025
Scientific Reports

Volume: 15, P: 1-11
Analogues of primeval galaxies two billion years after the Big Bang

A selected group of intermediate-redshift galaxies appear similar to primeval galaxies. Analysing spectra of these nearer analogues for chemical abundances and ionization levels gives an improved understanding of galaxies that are too faint to study well.

Ricardo Amorín
Adriano Fontana
Emiliano Merlin
Research02 Mar 2017
Nature Astronomy

Volume: 1, P: 1-8
A multi-source dataset of urban life in the city of Milan and the Province of Trentino

Gianni Barlacchi
Marco De Nadai
Bruno Lepri
ResearchOpen Access27 Oct 2015
Scientific Data

Volume: 2, P: 1-15
Improved gene transfer into canine hematopoietic repopulating cells using CD34-enriched marrow cells in combination with a gibbon ape leukemia virus–pseudotype retroviral vector

H-P Kiem
P A McSweeney
A D Miller
Research25 Jun 1999
Gene Therapy

Volume: 6, P: 966-972
Observation of Rayleigh-Lamb waves generated by the 2022 Hunga-Tonga volcanic eruption with the POLA detectors at Ny-Ålesund

M. Abbrescia
C. Avanzini
R. Zuyeuski
ResearchOpen Access20 Nov 2022
Scientific Reports

Volume: 12, P: 1-14
Treatment-free remission following frontline nilotinib in patients with chronic phase chronic myeloid leukemia: 5-year update of the ENESTfreedom trial

Jerald P. Radich
Andreas Hochhaus
Giuseppe Saglio
ResearchOpen Access11 Mar 2021
Leukemia

Volume: 35, P: 1344-1355
Reduced Myelin Signal in Normal-appearing White Matter in Neuromyelitis Optica Measured by 7T Magnetic Resonance Imaging

I-Jun Chou
Radu Tanasescu
Cris S. Constantinescu
ResearchOpen Access07 Oct 2019
Scientific Reports

Volume: 9, P: 1-10
Therapeutic effect of baicalin on experimental autoimmune encephalomyelitis is mediated by SOCS3 regulatory pathway

Yuan Zhang
Xing Li
Guang-Xian Zhang
ResearchOpen Access30 Nov 2015
Scientific Reports

Volume: 5, P: 1-15
Impact of measurable residual disease by decentralized flow cytometry: a PETHEMA real-world study in 1076 patients with acute myeloid leukemia

Bruno Paiva
María-Belen Vidriales
Pau Montesinos
Research01 Feb 2021
Leukemia

Volume: 35, P: 2358-2370
Multidisciplinary studies on a sick-leader syndrome-associated mass stranding of sperm whales (Physeter macrocephalus) along the Adriatic coast of Italy

Sandro Mazzariol
Cinzia Centelleghe
Giovanni Di Guardo
ResearchOpen Access01 Aug 2018
Scientific Reports

Volume: 8, P: 1-18
Locus coeruleus complex of the family Delphinidae

Simona Sacchini
Manuel Arbelo
Pedro Herráez
ResearchOpen Access03 Apr 2018
Scientific Reports

Volume: 8, P: 1-10
The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group

Khalid El Bairi
Harry R. Haynes
Paul J. Van Diest
ReviewsOpen Access01 Dec 2021
npj Breast Cancer

Volume: 7, P: 1-17

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