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In a trial examining the effectiveness of an infant mental health service targeting birth and foster families of children aged 0–5 years, families were randomized to receive care from either a multidisciplinary infant mental health team according to the New Orleans Intervention Model or social work services as usual. No difference in the mental health of children was found between the two arms.

Liposarcoma (LPS) is a rare cancer that can acquire resistance to chemotherapy. Here, the authors map super-enhancers in LPS, finding BET-protein dependent mechanisms that can be targeted by a BET protein degrader, which also can overcome acquired resistance to chemotherapy in LPS.

Here, the authors present genome-wide aDNA from 21 individuals who lived in the Chincha Valley (Peru) between the 13th and 16th centuries. These data reveal close-knit communities as well as long-distance migration and contribute to a better understanding of regional chronology.

This Commission aims to resolve the current dialysis policy challenges in Thailand and generate lessons for the global kidney community by drawing on empirical evidence, systems thinking and multidisciplinary expertise to generate policy goals and recommendations.

The genetic basis underlying resistance to Sclerotinia stem rot (SSR) in oilseed rape remains elusive. Here, the authors identify BnaA07.MKK9 as a pivotal regulator of SSR resistance in oilseed rape by GWAS, providing new insights into plant defense mechanisms against necrotrophic pathogens.

The effects of global biodiversity loss on local plant communities have been equivocal. Across 57,398 European time series, covering > 100 years, local plant diversity gains are often associated with rises in generalist and non-native plants.

The evolutionary origin of tumours remains largely unknown. Here, Domazet-Lošo et al. show evidence for naturally occurring tumours in the freshwater polyp, Hydra, and suggest that tumours have deep evolutionary roots.

The microbiomes associated with reef corals are complex and diverse. Here, the authors investigate fire coral clones naturally occurring in distinct habitats as a model system to disentangle the contribution of host genotype and environment on their microbiome, and predict genomic functions based on taxonomic profiles.

Part of the Hong Kong Genome Project, genomic analyses of more than 20,000 participants provide information on clinically relevant variants for the Chinese population and offer insights on the implementation of genomic medicine initiatives.

This study benchmarks 43 computational methods for identifying topologically associating domains (TADs), presents a tool based on a consensus strategy that leads to improved performance, and releases a web service to benchmark and use TAD calling methods.

Environmental justice and drinking water in the US: Higher proportions of Hispanic/Latino, American Indian/Alaskan Native, and non-Hispanic Black residents were associated with higher public water arsenic and uranium at the county-level, findings differed by region.

Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

By comparing newly produced RNA in the nucleus with mature RNA in the cytosol, genetic variants that control gene expression showed striking differences in localization and biological mechanisms, helping explain how they contribute to disease.

This study reveals how understory forest plants in the Central Amazon adapt their nutrient acquisition strategies in response to elevated atmospheric CO₂, based on an in situ open-top chamber experiment. To support the CO₂ fertilization effect, plants adjust contrasting strategies to extract nutrients from litter and soil layers. This process intensifies competition between plants and microbes and may lead to declines in soil organic phosphorus, with important implications for carbon–phosphorus dynamics and the resilience of forests under climate change.

DNA-sequencing data from primary tumours and paired metastases from participants in the TRACERx lung study and PEACE autopsy programme are used to analyse the metastatic diversity of advanced non-small cell lung cancer and the seeding patterns that underpin it.

Coral diseases contribute to the decline of reefs around the globe. This study reveals that disruptions of the nutrient balance in seawater can change coral-associated microbial communities leading to disease.

Religious expressions in public urban spaces can be contentious, with competing policies reflecting different expectations about whether such expressions support or undermine immigrant integration. Field experiments and surveys among Muslim immigrants show that exposure to Islamic symbols increases place integration in both Paris and London, despite their contrasting regulatory approaches to religious visibility.

Macrophage-specific genetic ablation of the EMT inducer ZEB1 reveals its pivotal role in intracellular cytokine trafficking, boosting cytotoxic T cell abundance and immune responses, thereby reducing tumor growth and metastatic colonization in mice.

Pathogenic variants in RBM20 cause an aggressive form of heart disease. van den Hoogenhof et al. show that overactivated CAMK2D drives this disease, and that pharmacological CAMK2D inhibition is a promising therapeutic approach in patients with RBM20 cardiomyopathy.

Here, the authors show that endothelial cells lining the blood vessels and red blood cells continually exchange glycocalyx sugars on their surface in health and disease. These exchanges enable the prediction of blood vessel damage by studying simultaneous red blood cell damage.

New research introduces a global, high-resolution power system model to show that achieving a net-zero electricity sector while ensuring equitable access to decent living standards is both technically feasible and economically viable by mid-century.

Rusca et al. propose the plural climate storylines framework to build on the narrative element of physical climate storylines with methods that emphasize power asymmetries, decoloniality, co-production and desired futures. The goal of pluralizing climate storylines is to promote just, equitable development interventions.

A large-scale study on the replicability of claims from social and behavioural science journals reports that about half of the results replicate in the same patterns as the original study.

Climate change and social health are deeply interconnected: climate impacts erode social conditions, while social disconnection weakens collective climate action. Strengthening social health is essential for resilience and effective policy.

Outdoor recreation is an essential component of forming an understanding of nature, and hunting and fishing are no exception. This Perspective looks at how these activities can generate feelings of stewardship towards the environment and wildlife.

Vertical transmission is thought to favour beneficial host–microbe interactions, but these may also be context dependent. Here Bruijning et al. show with a model that variable environments can select for bet-hedging by hosts via imperfect vertical transmission of microbes.

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

Global trade tightly links water, energy and food systems, but its effects on cross-border sustainability and equity remain unclear. A study now maps global water–energy–food trade networks, finding that trade balances overall resource gains while deepening cross-country income inequalities.

Large-scale biological data repositories, particularly when deployed as single, non-mirrored instances or governed within narrow contexts, face structural vulnerabilities, from cyberattacks to funding disruptions. We propose a hybrid framework that integrates federated and decentralized models to ensure the resilience, sustainability and FAIR/CARE stewardship of scientific data as a global public good.

This study identifies an FDA-approved leukemia drug, Homoharringtonine, that can eliminate aged fat cells, improve metabolic health, reduce inflammation and extend lifespan in mice, revealing a potential approach to treat age- and obesity-related metabolic disease.

In this study, authors investigate what happens to magma before a volcanic eruption. They find that crystals react to magma flow before it reaches the surface, preserving a mechanical fingerprint of the forces driving eruptions.

Pulmonary microbiotacomponents in bronchiectasis patients receive repeated antibiotic exposures, whereas previous studies on the effects ofantibiotic treatment focused on typical pathogens rather than commensals. By integrating experimental evolution withsingle-cell resolution, the authors reveal a multifaceted strategy by which Neisseria subflava, a common airwaycommensal associated with bronchiectasis, exploits antibiotic selection to transition towards pathogenicity.

Linker histone proteins (H1) play a key role in chromatin regulation, but their behavior in crowded nucleosome environments is poorly understood. Here, the authors show that different H1 variants bind and connect multiple nucleosomes in diverse ways, supporting dynamic chromatin organization.

IMiD-based PROTACs may degrade IKZF1/3 with hematologic effects. This study profiles these liabilities using hematopoietic assays showing stem cell rewiring and interferon activation and introduces a CRBN ligand that reduces them.

Cryogenic Li | |Cl₂ batteries face severe interfacial instability. Here, authors demonstrate a solvation reconfiguration strategy to build a robust interphase, enabling stable cycling of Li | |Cl₂ batteries for over 1100 cycles at –40 °C.

Immune checkpoint inhibitors (ICIs) have shown limited efficacy in recurrent high-grade astrocytoma (rHGA). Here the authors report the results of a Phase 1/randomized Phase 2b trial of laser interstitial thermal therapy followed by anti-PD1 pembrolizumab in patients with rHGA.

The effectiveness of marine protected areas remains uncertain. Studying 2,800 tropical reefs, the authors of this study show that marine protected areas have compensated for only a small portion of human impacts on fish contributions to people and nature, particularly in terms of biomass and biodiversity.

Façade-integrated photovoltaics (FIPV) present a promising yet early-stage solution for mitigating building emissions. Combining global building datasets, climate projections and façade-scale simulations, researchers estimate that FIPV could deliver substantial economic and climate benefits.

Adsorption of trace transition-metal cations endows common Ca/Mg-carbonates and phyllosilicates with catalytic activity for electrochemical CO2 reduction under planetary conditions, potentially promoting prebiotic chemistry and the origin of life.

Global links between plant diversity and productivity via reduced herbivore and pathogen damage remain unclear. This meta-analysis shows that conserving diverse plant communities can potentially lower biotic losses and boost productivity.

Analysing 30 cities worldwide, this study identifies bidirectional yet asymmetric causality between urban systems and traffic dynamics, revealing that urban systems more strongly shape mobility patterns than traffic feeds back into cities.

In this Review, Vasse and Velicer explore the phylogenetic and functional diversity of predators of microorganisms, conceptualizing the forms of microbial predation along gradients, including gradients of evolutionary adaptedness for predation and privatization of prey-derived nutrients.

Autophagy has a highly complex and context-dependent role in cancer, challenging the development of autophagy-modulating strategies. This Review discusses the potential of targeting autophagy to counteract malignant transformation, prevent disease progression and enable anticancer immunosurveillance. Existing and emerging pharmacological strategies and the associated limitations are critically presented.