This study reports that the induction of the transcription factor ΔFosB is critical for mice to show resilience to the effects of chronic social defeat stress and for antidepressant responses in susceptible mice. ΔFosB acts to promote resilience by the induction of the GluR2 AMPA glutamate subunit, which decreases the responsiveness of nucleus accumbens neurons to glutamate.
- Vincent Vialou
- Alfred J Robison
- Eric J Nestler