Bicyclo[1.1.1]pentane (BCP) boronic esters are crucial synthetic intermediates for the synthesis of a variety of BCP-containing drugs with improved pharmacokinetic properties. Here, the authors report a general approach to BCP boronic ester via direct, single-step decarboxylation of carboxylic acids.
- Yongchen Wang
- Jess C. Tang
- Julian G. West