Augello et al. assess long-term immune responses to Omicron BA.4/5 booster in people living with HIV. The vaccine enhances immunity, with T cell responses stable and cross-reactive but antibody responses short-lived and imprinted to the ancestral virus; HIV-related T cell dysfunction reduces antibody peak and durability.
- Matteo Augello
- Valeria Bono
- Giulia Marchetti
