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Showing 1–15 of 15 results
Advanced filters: Author: Carolina M. Polonio Clear advanced filters

  • Using viral barcode tracing to detect interactions between glioblastoma cells and non-malignant astrocytes in patient samples, investigators discovered a pathway that reduces tumour-specific immunity and identified potential therapeutic targets.

    • Brian M. Andersen
    • Camilo Faust Akl
    • Francisco J. Quintana
    Research
    Nature
    Volume: 644, P: 1097-1106

  • A population of TRAIL-positive astrocytes in glioblastoma contributes to an immunosuppressive tumour microenvironment and this mechanism can be targeted with an engineered oncolytic virus to improve outcomes.

    • Camilo Faust Akl
    • Brian M. Andersen
    • Francisco J. Quintana
    Research
    Nature
    Volume: 643, P: 219-229

  • Inflammatory monocytes in the brain meninges promote stress-induced fear behaviour, and the pathways involved can be modulated using psychedelic compounds.

    • Elizabeth N. Chung
    • Jinsu Lee
    • Michael A. Wheeler
    Research
    Nature
    Volume: 641, P: 1276-1286

  • Giovannoni et al. report that the aryl hydrocarbon receptor (AHR) is a novel host factor exploited by Zika virus and dengue virus to evade the immune response. AHR is a candidate target for the treatment of Zika virus congenital syndrome and dengue fever.

    • Federico Giovannoni
    • Irene Bosch
    • Francisco J. Quintana
    Research
    Nature Neuroscience
    Volume: 23, P: 939-951

  • Lactate produced by dendritic cells (DCs) suppresses T-cell-mediated autoimmunity through a mechanism in which lactate activates HIF-1α–NDUFA4L2 signalling in DCs and thereby limits DC-mediated pro-inflammatory responses such as the development of encephalitogenic T cells.

    • Liliana M. Sanmarco
    • Joseph M. Rone
    • Francisco J. Quintana
    Research
    Nature
    Volume: 620, P: 881-889

  • The herbicide propyzamide increases inflammation in the small and large intestine, and the AHR–NF-κB–C/EBPβ signalling axis—which operates in T cells and dendritic cells to promote intestinal inflammation—is targeted by propyzamide.

    • Liliana M. Sanmarco
    • Chun-Cheih Chao
    • Francisco J. Quintana
    Research
    Nature
    Volume: 611, P: 801-809

  • The pathogenic function of XBP1-expressing astrocytes in experimental autoimmune encephalomyelitis and multiple sclerosis have been studied using FIND-seq, a new method combining microfluidics cytometry, PCR-based detection of nucleic acids and cell sorting for in-depth single-cell transcriptomics analyses of rare cells.

    • Iain C. Clark
    • Michael A. Wheeler
    • Adam R. Abate
    Research
    Nature
    Volume: 614, P: 326-333

  • A subpopulation of astrocytes characterized by the expression of LAMP1 and TRAIL limits inflammation in the central nervous system through a mechanism involving the microbiota-modulated expression of IFNγ in meningeal natural killer cells.

    • Liliana M. Sanmarco
    • Michael A. Wheeler
    • Francisco J. Quintana
    Research
    Nature
    Volume: 590, P: 473-479

  • Microbial networks and host–microbiota interactions, especially immunoglobulin A coating of resident microbiota, outperform bacterial abundance as a predictor of neuroinflammation severity in a mouse model of multiple sclerosis.

    • Carolina M. Polonio
    • Francisco J. Quintana
    News & Views
    Nature Microbiology
    Volume: 9, P: 2204-2205

  • Sepsis results from a dysregulated immune response to infection. A study now shows that gut microbiota-derived metabolites prevent infection-triggered immunopathology by activating the aryl hydrocarbon receptor; pathogens inhibit this protective mechanism.

    • Carolina M. Polonio
    • Francisco J. Quintana
    News & Views
    Nature Immunology
    Volume: 26, P: 155-156

  • The aryl hydrocarbon receptor (AHR) mediates the toxic effects of environmental pollutants and regulates innate and adaptive immune responses. This Review discusses how, in the past, AHR activation was avoided during drug development, but now the AHR is being targeted for treating inflammation, cancer and infectious diseases.

    • Carolina M. Polonio
    • Kimberly A. McHale
    • Francisco J. Quintana
    Reviews
    Nature Reviews Drug Discovery
    Volume: 24, P: 610-630

  • An extensive collapse of the south Scandinavian Caledonides is evident from large-scale folding and shear zones observed in the offshore basement of the North Sea Rift, using modern 3D broadband seismic data.

    • Haakon Fossen
    • Israel Polonio
    • Carolina Cavalcante
    ResearchOpen Access
    Communications Earth & Environment
    Volume: 5, P: 1-13