Constructing organic fluorophosphines via direct fluorination of alkyl phosphonates is challenging. Herein, the authors show that alkyl phosphonates are electrophilically activated with triflic anhydride and N-heteroaromatic bases, enabling nucleophilic fluorination at room temperature to form fluorophosphines via reactive phosphine intermediates.
- Kaiqiang Zhang
- Wanru Feng
- Zijing Li
