Search

Inspired by rebar steel-reinforced concrete (RC) structures used in buildings, aluminum matrix composites are designed which achieve nearly 1 GPa in yield strength and specific strength of (235 kN·m/kg) at 400 °C.

Middle-aged individuals are more susceptible to obesity, but the mechanisms are unclear. Here, the authors show that extracellular vesicles from adipose progenitor cells in middle-aged individuals lack miR-145-5p, driving inflammation, and that restoring miR-145-5p could prevent midlife obesity.

DeepMVP is a deep learning framework for predicting PTM sites and variant-induced alterations across six modification types, including phosphorylation, acetylation, methylation, sumoylation, ubiquitination and N-glycosylation.

Clean photoelectrochemical water oxidation can yield H₂O₂, but its mechanism remains unclear. Using time-resolved spectroscopy, the authors report the first-order reaction kinetics and accelerated consumption of the first-hole intermediates in H₂O₂ evolution.

Protein kinase-mediated phosphorylation plays a critical role in many biological processes. Here the authors develop a trans-omics-based algorithm called Central Kinase Inference to integrate quantitative transcriptomic and phosphoproteomic data, finding that PIM1 promotes hepatic conversion by suppressing reprogramming-induced ferroptosis and cell cycle arrest.

Phosphorylation plays an important role in the regulation of molecular circadian clocks. Here the authors utilize multi-omics data from flies to describe the circadian kinome and identify GASKET as a potentially important regulator within the circadian kinase network.

Defect-assisted nonradiative recombination and carrier aggregation at the interface hinder the potential of perovskites as emitter for light-emitting diodes. Here, Fang et al. achieve an external quantum efficiency of 24.1% by combining multidimensional perovskite with cascade conduction bands.

The development of a new smallsample learning framework, KprFunc, leads to the discovery of an important role for lysine propionylation in determining global protein homeostasis, mediated by a critical propionylation site on histone H2B, H2BK17pr.

Transistor scaling degrades intrinsic gain, challenging analog circuit design. The authors fabricated carbon nanotube thin-film transistors with gate-modulated negative differential resistance, achieving high and variable intrinsic gain, even at deep-submicron scales.

Single cell RNA-seq is a powerful method to assign cell identity, but the purity of cell clusters arising from this data is not clear. Here the authors present an entropy-based statistic called ROGUE to quantify the purity of cell clusters, and identify subtypes within clusters.

Despite being an effective treatment for hepatocellular carcinoma (HCC), resistance to oxaliplatin presents a major obstacle. Here, the authors identify PRMT3-induced methylation of IGF2BP1 resulting in HEG1 stabilisation as a mechanism of oxaliplatin resistance in HCC.

Yardena Samuels and colleagues report a mutational analysis of the matrix metalloproteinase gene family in cutaneous metastatic melanoma. They find frequent somatic mutations in MMP8 and present functional evidence that wild-type MMP-8 inhibits melanoma progression.

Quantitative mass-spectrometry-based proteomic and phosphoproteomic analyses of genomically annotated human breast cancer samples elucidates functional consequences of somatic mutations, narrows candidate nominations for driver genes within large deletions and amplified regions, and identifies potential therapeutic targets.

Prioritizing candidate biomarkers for verification remains a formidable obstacle to the translation of protein diagnostics to clinical applications. Whiteaker et al. assemble a multistage, targeted proteomics pipeline to relieve this bottleneck and use a mouse cancer model to demonstrate its analytical performance.

Cotton gauze is widely used as haemostatic material for bleeding control, but its high blood absorption capacity can to cause extra blood loss. Here, the authors develop a cotton gauze whose surface is modified with a catechol compound featuring a flexible long hydrophobic alkyl chain which demonstrates excellent haemostatic performance.

Luis Pérez-Jurado, Stephen Chanock and colleagues detect clonal chromosomal abnormalities in peripheral blood or buccal samples from individuals in the general population. They show that the frequency of such events increases with age and is associated with elevated risk of developing subsequent hematological cancers.

Although autophagy has been linked to tumourigenesis, it is unclear how genomic alterations affect autophagy selectivity in tumours. Here, the authors establish a pipeline that integrates computational and experimental approaches to show that altered autophagy selectivity is frequent in cancer cells and link glycogen autophagy with tumourigenesis.

Observations of highly redshifted broad absorption lines of helium and hydrogen atoms provide unambiguous evidence of fast infalling gas that is merging into an accretion disk around a black hole.

Large-scale exome association analysis of UKBB data examining seven cerebellar traits, identifies 90 genes, 60 of which are novel, and suggests links between cerebellar volume and microstructure, and neuropsychiatric diseases.

This Analysis reports the development and assessment of 645 multiple reaction monitoring (MRM) mass spectrometry assays to quantify 319 targeted human breast cancer proteins. The results of this pilot project coordinated among three individual groups suggest that an organized international effort to generate MRM assays to the human proteome will be possible.

Inspired by the design philosophy of classical rebar steel-reinforced concrete in building industry, continuous Ti alloy reinforced aluminum matrix composites (AMCs) were architected for the first time by an original micro-casting process in this study. The yield strengths of present AMC samples reach 400~660 MPa, which are much higher than all the commercial or laboratorial cast Al-Si alloys (55~310 MPa). With the help of 3D printing technology, the present method makes it possible to “architect” the AMC like building a house, and reinforce the matrix at the designed position.

The oncogenic role of RAD21 in NSCLC is mediated by NIPBL via H3K27 demethylation and suggest its use as a potential novel diagnostic marker and therapeutic target for NSCLC.