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Pancreatic cancer

In this Primer, Roth et al. discuss the epidemiology, current knowledge of pathophysiology, diagnosis, management and quality of life of individuals with pancreatic ductal adenocarcinoma, which remains one of the deadliest malignancies globally.

Susanne Roth
Minoti Apte
Christoph W. Michalski
Reviews07 May 2026
Nature Reviews Disease Primers

Volume: 12, P: 1-22
Publisher Correction: Deciphering the role of complement system genes in pancreatic cancer susceptibility and prognosis

Alberto Langtry
Raul Rabadan
Linda Sharp
Amendments and CorrectionsOpen Access02 Feb 2026
Nature Communications

Volume: 17, P: 1
Deciphering the role of complement system genes in pancreatic cancer susceptibility and prognosis

The role of the complement system (CS) - part of the immune system - in pancreatic ductal adenocarcinoma (PDAC) remains underexplored. Here, the authors evaluate the association of genetic variants in CS-related genes with PDAC risk, and explore their potential role in prognosis and immune infiltration.

Alberto Langtry
Raul Rabadan
Linda Sharp
ResearchOpen Access28 Nov 2025
Nature Communications

Volume: 16, P: 1-12
Hematopoietic colony–stimulating factors mediate tumor-nerve interactions and bone cancer pain

Pain is one of the many debilitating side effects of cancer. Now, Rohini Kuner and her colleagues show that blocking hematopoietic colony-stimulating factor signaling on neurons can inhibit pain caused by bone cancer.

Matthias Schweizerhof
Sebastian Stösser
Rohini Kuner
Research07 Jun 2009
Nature Medicine

Volume: 15, P: 802-807
Polyphosphonate covalent organic frameworks

Covalent organic frameworks (COFs) can be synthesized through a wide range of reactions but phosphonate-COFs remained elusive. Here the authors report a polyphosphonate-COFs constructed via P-O-P linkages with good water and exceptional electrochemical stability.

Ke Xu
Robert Oestreich
Gündoğ Yücesan
ResearchOpen Access09 Sept 2024
Nature Communications

Volume: 15, P: 1-11
The role of stroma in pancreatic cancer: diagnostic and therapeutic implications

Abundant fibrotic stroma is a typical feature of pancreatic ductal adenocarcinoma (PDAC) in humans. It is becoming clear that this stromal tissue is not just a bystander in PDAC, but has a crucial role in tumorigenesis, angiogenesis and resistance to therapy. Targeting the stroma for diagnostic and therapeutic purposes opens a new avenue of research in the management of PDAC.

Mert Erkan
Simone Hausmann
Helmut Friess
Reviews19 Jun 2012
Nature Reviews Gastroenterology & Hepatology

Volume: 9, P: 454-467
Surgery for synchronous and metachronous single-organ metastasis of pancreatic cancer: a SEER database analysis and systematic literature review

Qiaofei Liu
Ronghua Zhang
Jorg Kleeff
ResearchOpen Access10 Mar 2020
Scientific Reports

Volume: 10, P: 1-10
Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors

Nitin Agarwal
Pal Pacher
Rohini Kuner
Research10 Jun 2007
Nature Neuroscience

Volume: 10, P: 870-879
Surgery Insight: surgical management of pancreatic cancer

Despite recent advances in the field of medical and radiation oncology, and the introduction of neoadjuvant and adjuvant regimens, surgery remains the single most important modality for the treatment of pancreatic ductal adenocarcinoma. This Review discusses the technical improvements that have made pancreatic surgery safe, with low morbidity and mortality rates in tertiary referral centers, and it highlights the challenges of surgical palliation.

Christoph W Michalski
Jürgen Weitz
Markus W Büchler
Reviews01 Sept 2007
Nature Clinical Practice Oncology

Volume: 4, P: 526-535
From tissue turnover to the cell of origin for pancreatic cancer

In this Perspectives, the authors contemplate the identity of the cell of origin for pancreatic ductal adenocarcinoma. They hypothesize that a subset of cells that renew the adult organ physiologically or regenerate it upon severe tissue damage would be more susceptible to oncogenic transformation than mature, differentiated cells. They contend that such a cellular compartment could consist of putative pancreatic stem cells, progenitor cells, facultative stem cells or transdifferentiated bone marrow cells.

Bo Kong
Christoph W. Michalski
Jörg Kleeff
Reviews12 Jul 2011
Nature Reviews Gastroenterology & Hepatology

Volume: 8, P: 467-472
ALDH1A3 promotes aggressive basal-like pancreatic cancer through an AP-1/RUNX2 enhancer network

Xiaoping Zou
Shuang Nie
Bo Kong
ResearchOpen Access08 Aug 2025
Oncogene

Volume: 44, P: 3774-3786
Northern blot analysis for detection and quantification of RNA in pancreatic cancer cells and tissues

Sylvia Streit
Christoph W Michalski
Helmut Friess
Protocols11 Dec 2008
Nature Protocols

Volume: 4, P: 37-43
A common genetic variation of melanoma inhibitory activity-2 labels a subtype of pancreatic adenocarcinoma with high endoplasmic reticulum stress levels

Bo Kong
Weiwei Wu
Christoph W. Michalski
ResearchOpen Access06 Feb 2015
Scientific Reports

Volume: 5, P: 1-10
Surface clay formation during short-term warmer and wetter conditions on a largely cold ancient Mars

A geochemical model for the state of early Mars suggests that short-term warm events grafted onto a generally cold climate could form Al-rich phyllosilicates in short-lived surface water bodies and Mg-rich ones in hydrothermal subsurface environments.

Janice L. Bishop
Alberto G. Fairén
Elizabeth B. Rampe
Research05 Feb 2018
Nature Astronomy

Volume: 2, P: 206-213
Multiscale and multimodal imaging for three-dimensional vascular and histomorphological organ structure analysis of the pancreas

Gabriel Alexander Salg
Verena Steinle
Hannes Goetz Kenngott
ResearchOpen Access02 May 2024
Scientific Reports

Volume: 14, P: 1-15
New implications from long-term outcomes of perioperative therapy in resectable pancreatic cancer

Christoph Springfeld
Thilo Hackert
John P. Neoptolemos
ReviewsOpen Access04 Dec 2025
British Journal of Cancer

Volume: 134, P: 531-542
Peroxisome Proliferator-Activated Receptor gamma negatively regulates liver regeneration after partial hepatectomy via the HGF/c-Met/ERK1/2 pathways

Zhangjun Cheng
Lei Liu
Norbert Hüser
ResearchOpen Access08 Aug 2018
Scientific Reports

Volume: 8, P: 1-10
Molecular, morphological and survival analysis of 177 resected pancreatic ductal adenocarcinomas (PDACs): Identification of prognostic subtypes

Anna Melissa Schlitter
Angela Segler
Irene Esposito
ResearchOpen Access01 Feb 2017
Scientific Reports

Volume: 7, P: 1-12

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