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Cell therapy requires the targeting of cells to specific sites in the body. Here Muthana et al.use a standard MRI scanner to direct oncolytic macrophages, labelled with magnetic nanoparticles, to primary and metastatic tumour sites in mice, and demonstrate that this leads to reduced tumour growth.

Femtosecond X-ray solution scattering reveals how solvent environments direct the outcome of ultrafast roaming reactions in bromoform, determining whether transient hot isomers undergo rapid solvolysis or rearrange into long-lived isomeric products.

Pesnot Lerousseau and Summerfield compare humans to transformer neural networks in a learning task designed to distinguish ‘in-weights’ and ‘in-context’ learning processes.

The paper analyzes the impact of omitting biophysical effects from carbon credits on climate mitigation. It shows that some Voluntary Carbon Market projects may result in net warming due to albedo while others enhance cooling.

A range of environmental stressors are estimated for farmed and wild capture blue foods, including bivalves, seaweed, crustaceans and finfish, with the potential to inform more sustainable diets.

High-speed programmability of spatially-structured light imparts faster control upon atomic qubits. Here, the authors demonstrate reconfigurable GHz-rate modulation on sixteen visible-wavelength channels, used here to address color centers in diamond.

The conversational diagnostic artificial intelligence system AMIE (Articulate Medical Intelligence Explorer) has potential as a real-world tool for clinical history-taking and diagnostic dialogue, based on its performance in simulated consultations.

Understanding the dynamics of how drug resistance originates in cancer remains crucial, but it is not possible to observe them directly. Here, the authors construct a mathematical framework to infer drug resistance dynamics in cancer using lineage tracing and population size data, which is confirmed with experimental evidence and single-cell sequencing.

Synthetic methods that efficiently construct structurally diverse molecular scaffolds are attractive routes to diversely bioactive molecules. Here the authors report a method whereby common starting materials are converted to structurally and functionally diverse products by changing the catalyst ligand.

Policies that centre principles of justice and human rights, specify inclusive decision-making processes and identify and challenge underlying drivers of injustice are linked to more just food system outcomes.

Synthetic biology can be used to create rationally designed living therapeutics. Here the authors engineer E. coli Nissle to target STING activation in antigen presenting cells for the treatment of solid tumors and demonstrate preclinical activity in murine models.

Conventional structural biology techniques are limited in deciphering complex RNA structures and dynamic interactions. Here the authors show an integrated approach that combines cryogenic OrbiSIMS (cryo-OrbiSIMS) with computational methods for modelling RNA structures at atomic resolution.

Known genetic loci account for only a fraction of the genetic contribution to Alzheimer’s disease. Here, the authors have performed a large genome-wide meta-analysis comprising 409,435 individuals to discover 6 new loci and demonstrate the efficacy of an Alzheimer’s disease polygenic risk score.

A better understanding of the development and progression of heterogeneity in oesophageal adenocarcinoma and its precursor condition, Barrett oesophagus, is crucial for improving surveillance and treatment strategies. The authors of this Review outline the current knowledge of the causes, mediators and therapeutic implications of spatial and temporal heterogeneity in these diseases.

Evolution has produced a range of diverse proteins, and now a generative model called Chroma can expand that set by allowing the user to design new proteins and protein complexes with desired properties and functions.

Pump–probe measurements conventionally achieve femtosecond time resolution for X-ray crystallography of reactive processes, but the measured structural dynamics are complex. Using coherent control techniques, we show that the ultrafast crystallographic differences of a fluorescent protein are dominated by ground-state vibrational processes that are unconnected to the photoisomerization reaction of the chromophore.

This work presents ultracompact and low-power laser beam scanners using microcantilevers embedded with nanophotonic circuits. These chip-scale devices are made in a semiconductor foundry and project visible light patterns in one or two dimensions.

The February 2023 Kahramanmaraş earthquake doublet reveals how pre-stress and local stress heterogeneity influence fault ruptures, with key insights into rupture kinematics, fault geometry, and stress interactions along complex fault systems.

Mixed Lineage Kinase Domain-Like (MLKL) pseudokinase is phosphorylated by RIPK3 kinase prior to cell death by necroptosis. Here, the authors use monobodies that bind to the MLKL pseudokinase domain as tools, which allowed them to determine the crystal structures of the MLKL pseudokinase domain in two distinct conformations. By combining their structural data with cell signalling assays and MD simulations they provide evidence that endogenous MLKL preassociates with its upstream regulator RIPK3, and that MLKL disengages from RIPK3 following the induction of necroptosis.

A compact, high-performance silicon photonics-based light detection and ranging system for three-dimensional imaging is developed that should be amenable to low-cost mass manufacturing

Oxides with a face-centred cubic anion sublattice are generally not considered as solid-state electrolytes. Li superionic conductivity in face-centred cubic oxides with face-sharing Li configurations have now been created through cation over-stoichiometry in rocksalt-type lattices via excess Li.

DNA methylation plays an important role in regulating a wide variety of cellular processes and is implicated in a range of diseases. Here the authors present Casilio-ME to assemble protein complexes to demethylate target loci.

Since their initial operation, free-electron lasers are regularly upgraded in their performance and parameter control. Here the authors present the first lasing results of the soft X-ray free-electron laser beamline of the Paul Scherrer Institute, demonstrating different modes of operation and polarisation control of the tailored soft X-ray pulses.

Patients with metastatic cancers of unknown primary (CUP) are currently unable to gain access to drugs through standard of care or clinical trials. Here, the authors perform whole-genome and transcriptome sequencing (WGTS) on 72 patients with CUP and demonstrate the feasibility of using WGTS to determine the specific cancer types of CUP, thereby clinically benefiting patients with CUP.

This study presents the first annual update of the indicator framework developed by the Food Systems Countdown Initiative, published in Nature Food in 2023. Almost half of all indicators show some desirable trends. Governance and resilience indicators were revealed as the most connected across themes, constituting entry points for transformative change.

How tropical cyclones have varied in intensity and frequency in the past is not well known as longer records are rare. Here, the authors show that changes in observing practices explain the recorded century scale increase in Atlantic major hurricane frequency, and recent increases are not part of a century-scale trend.

Identifying rare cell populations is key to understanding cancer progression and response to therapy. Here, authors introduce MarsGT, an end-to-end deep learning model for rare cell population identification from scMulti-omics data.

Relativistic Dirac fermions can be locally confirmed in nanoscale graphene quantum dots using electrostatic gating, and directly imaged using scanning tunnelling microscopy before escaping via Klein tunnelling.

Panuski et al. demonstrate a programmable photonic crystal cavity array, enabling the spatiotemporal control of a 64 resonator, two-dimensional spatial light modulator with nanosecond- and femtojoule-order switching.

The finding that a thin sheet of fibrous tissue under the skin contains a prefabricated, movable cellular sealant that can heal deep wounds might have implications for the treatment of scars and ulcers.

Coupling technological advances with sociocultural and policy changes can transform agri-food systems to address pressing climate, economic, environmental, health and social challenges. An international expert panel reports on options to induce contextualized combinations of innovations that can balance multiple goals.

Resistance to therapy can be driven by intratumoral heterogeneity. Here, the authors show that drug tolerant persistent cell populations emerge during treatment, and these emergent populations arise through epigenetically mediated cell state transitions rather than sub population selection.

Is it time to reassess the 14-day rule for human embryo research?

The TCR-peptide-MHC interface is composed of conserved and diverse regions, but the relative contributions of each in shaping T cell recognition remain unclear. Garcia and colleagues show consistent germline interactions between TCR and MHC, but enough flexibility in the TCR-peptide-MHC interface to allow adjustment for different peptides.

Here, Kropp et al. use cryo-electron microscopy and structural modeling to show that the enzyme [MoCu]-CO dehydrogenase interacts with its partner, the membrane-bound quinone-binding protein CoxG, to facilitate electron transfer from atmospheric CO oxidation to the respiratory chain. This interaction is conserved across diverse bacteria and archaea.

Dimethyl fumarate (DMF) is an anti-inflammatory drug proposed as a treatment for COVID19. Here the results are reported from a randomised trial testing DMF treatment in 713 patients hospitalised with COVID-19. DMF was not associated with any improvement in day 5 outcomes.