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Single-round evolution of RNA aptamers with GRAPE-LM

Combining generative AI and one round of wet lab evolution generates high-affinity RNA aptamers.

Jun Zhang
Ju Zhang
Yu Wang
Research06 Feb 2026
Nature Biotechnology

P: 1-13
Author Correction: Real-time monitoring of reaction stereochemistry through single-molecule observations of chirality-induced spin selectivity

Chen Yang
Yanwei Li
Xuefeng Guo
Amendments and Corrections14 Oct 2024
Nature Chemistry

Volume: 17, P: 298
Atomically precise construction of uniform single-molecule junctions for molecular electronics

Graphene-based electrodes are limited by difficulty in controlling the geometry and variability. Here, the authors present a method to construct covalently bonded, uniform, and high-yield graphene-molecule-graphene single-molecule junctions with high stability and atomic precision.

Mingyao Li
Bing Yin
Xuefeng Guo
ResearchOpen Access18 Aug 2025
Nature Communications

Volume: 16, P: 1-11
Full on-device manipulation of olefin metathesis for precise manufacturing

Single-molecule electrical detections clarify both productive and hidden degenerate pathways of ring-closing metathesis, and enable precise on-device synthesis of a single polymer with single-monomer-insertion-event resolution.

Yilin Guo
Chen Yang
Xuefeng Guo
Research08 Nov 2024
Nature Nanotechnology

Volume: 20, P: 246-254
Precise electrical gating of the single-molecule Mizoroki-Heck reaction

Guiding chemical reactions in a predictable and controllable manner is an ultimate goal of chemistry. Here, the authors show tuning of the single-molecule Mizoroki-Heck catalytic cycle through electrical gating and direct in-situ detection.

Lei Zhang
Chen Yang
Xuefeng Guo
ResearchOpen Access05 Aug 2022
Nature Communications

Volume: 13, P: 1-11
Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition

Cui, Guo, Liu et al. identify a bacterial species, Peptostreptococcus anaerobius, in the gut that produces a tryptophan metabolite and engages intracellular pathways to modulate ferroptosis-suppressor protein 1 activity, thereby suppressing ferroptosis and promoting colorectal cancer development.

Weiwei Cui
Meng Guo
Bo Chu
Research02 Jan 2024
Nature Cell Biology

Volume: 26, P: 124-137
Real-time monitoring of reaction stereochemistry through single-molecule observations of chirality-induced spin selectivity

In situ chirality identification for single-molecule systems is not a straightforward task. Now, real-time chirality identification during a Michael addition reaction has been realized by continuous measurements of spin-polarized currents through a single-molecule junction, providing a promising method for studying symmetry-breaking reactions.

Chen Yang
Yanwei Li
Xuefeng Guo
Research15 May 2023
Nature Chemistry

Volume: 15, P: 972-979
Direct observation of single-molecule hydrogen-bond dynamics with single-bond resolution

Hydrogen-bonds are widely found in many systems, such as DNAs and supramolecular assemblies, but it remains challenging to detect their dynamics at a molecular level. Here, Zhou et al. study the stochastic arrangement of hydrogen bonds using single-molecule junctions connected to graphene electrodes.

Ce Zhou
Xingxing Li
Xuefeng Guo
ResearchOpen Access23 Feb 2018
Nature Communications

Volume: 9, P: 1-9
A general one-step plug-and-probe approach to top-gated transistors for rapidly probing delicate electronic materials

A one-step simultaneous van der Waals integration of high-k dielectrics and contacts enables the realization of top-gated transistors with atomically clean and electronically sharp interfaces.

Laiyuan Wang
Peiqi Wang
Xiangfeng Duan
Research20 Oct 2022
Nature Nanotechnology

Volume: 17, P: 1206-1213
Highly durable, coking and sulfur tolerant, fuel-flexible protonic ceramic fuel cells

Tests on a versatile protonic ceramic fuel cell resistant to carbon deposition and sulfur poisoning show that its durability and the wide range of fuels it can accept make it suitable for use in industry in the near future.

Chuancheng Duan
Robert J. Kee
Ryan O’Hayre
Research09 May 2018
Nature

Volume: 557, P: 217-222
Reactions in single-molecule junctions

Investigating single-molecule reactions will deepen our understanding of chemical reactions and establish new frameworks in materials science. This Review summarizes the chemical reactions occurring in single-molecule junctions, discusses how they differ from reactions in the bulk, and explores the possibility of leveraging single-molecule catalysis for large-scale synthesis.

Hongliang Chen
Chuancheng Jia
J. Fraser Stoddart
Reviews02 Dec 2022
Nature Reviews Materials

Volume: 8, P: 165-185

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