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Showing 1–5 of 5 results
Advanced filters: Author: Chuanliu Wu Clear advanced filters

  • The precise pairing of cysteine residues in proteins is routinely achieved in nature. However, the comparable pairing within polypeptides is a long-standing challenge for the preparation of multicyclic species. Here, a straightforward approach to direct the inter-/intramolecular pairing of cysteine residues within peptides using a minimal CXC motif is presented.

    • Chuanliu Wu
    • Jean-Christophe Leroux
    • Marc A. Gauthier
    Research
    Nature Chemistry
    Volume: 4, P: 1044-1049

  • Multicyclic peptides have the potential to mimic the antigen-binding potency of the complementarity-determining regions of antibodies, enabling the development of potent peptide binders to challenging targets, but the scaffolds of multicyclic peptides are difficult to engineer. Here, the authors design a range of triscysteine motifs with disulfide-directing capability for regulating the oxidative folding of multicyclic peptides and employ them in the design of disulfide-directed multicyclic peptide libraries for discovery of potent peptide binders.

    • Zengping Duan
    • Chuilian Kong
    • Chuanliu Wu
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • Peptide heterodimers are prevalent in nature, which are not only functional macromolecules but molecular tools for chemical and synthetic biology. Here the authors report de novo design and directed folding of peptide heterodimers crosslinked through multiple disulfide bonds, which can be explored as chemical tools for orthogonal labeling of proteins and preparing protein hybrids.

    • Sicong Yao
    • Adam Moyer
    • Chuanliu Wu
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • In 1961, it was demonstrated that the enzyme ribonuclease can correctly fold upon oxidation in air from a fully reduced and denatured polypeptide chain. Since then, the principles that govern the oxidative folding of polypeptide chains have been elucidated, and our ability to control this process has advanced significantly.

    • Chuanliu Wu
    News & Views
    Nature Reviews Chemistry
    Volume: 9, P: 363-364