Nature Search

Targeting tumor-intrinsic BCL9 reverses immunotherapy resistance by eliciting macrophage-mediated phagocytosis and antigen presentation

Immune checkpoint inhibitors have shown promise in tumour immunotherapy but resistance has been seen. Here using pre-treatment hepatocellular carcinoma patient biopsies from patients scheduled for immunotherapy, the authors implicate BCL9 and show that a BCL9-targeting peptide promotes anti-tumour immunity in mouse models through targeting macrophages and promoting anti-tumour T cell responses.

Sui-Yi Wu
Yuan-Yuan Zhu
Xin-Rong Yang
ResearchOpen Access17 Nov 2025
Nature Communications

Volume: 16, P: 1-20
Nature's contribution to today's pharmacopeia

Lin Tao
Feng Zhu
Yu Zong Chen
Correspondence09 Oct 2014
Nature Biotechnology

Volume: 32, P: 979-980
Flash annealing boosts piezoelectricity of PVDF-TrFE

Poly(vinylidene fluoride-co-trifluoroethylene)’s (PVDF-TrFE) piezoelectricity can be enhanced by annealing, however current annealing methods are slow. Here, the authors perform ultra-fast flash annealing of PVDF-TrFE to achieve a high piezoelectricity.

Yi-Di Hu
Chun-Yan Tang
Wei Yang
ResearchOpen Access16 Dec 2025
Nature Communications

Volume: 16, P: 1-10
Author Correction: Transcriptomics-based investigation of manganese dioxide nanoparticle toxicity in rats’ choroid plexus

Chun-Yan Meng
Xin-Yi Ma
Fu-Min Feng
Amendments and CorrectionsOpen Access23 Apr 2024
Scientific Reports

Volume: 14, P: 1
Adeno-associated virus-mediated bone morphogenetic protein-7 gene transfer induces C2C12 cell differentiation into osteoblast lineage cells

Min Yang
Qing-jun Ma
Chun-yan Zhou
Research01 Aug 2005
Acta Pharmacologica Sinica

Volume: 26, P: 963-968
Rat adipose-derived stromal cells expressing BMP4 induce ectopic bone formation in vitro and in vivo

Lin Lin
Xin Fu
Chun-yan Zhou
Research01 Dec 2006
Acta Pharmacologica Sinica

Volume: 27, P: 1608-1615
Semaglutide ameliorates cardiac remodeling in male mice by optimizing energy substrate utilization through the Creb5/NR4a1 axis

Semaglutide is used for glucose control and weight reduction. Here, the authors show that it enhances myocardial metabolism by targeting Creb5/NR4a1, protecting against cardiac remodeling and offering a therapeutic approach for heart failure through metabolic regulation.

Yu-Lan Ma
Chun-Yan Kong
Qi-Zhu Tang
ResearchOpen Access04 Jun 2024
Nature Communications

Volume: 15, P: 1-19
Publisher Correction: E3 ubiquitin ligase UBR5 modulates circadian rhythm by facilitating the ubiquitination and degradation of the key clock transcription factor BMAL1

Chun-yan Duan
Yue Li
Guoqiang Xu
Amendments and Corrections20 Jun 2024
Acta Pharmacologica Sinica

Volume: 45, P: 2684
Stability and iron affinity of Donkey-hide gelatin hydrolysates: Implications for improving iron bioavailability and gut microbiota modulation

Hao-Bin Lin
Chun-Yan Peng
Xiao-Mei Sha
ResearchOpen Access26 Nov 2025
npj Science of Food

Volume: 9, P: 1-11
Development of a nested-PCR assay for the rapid detection of Pilidiella granati in pomegranate fruit

Xue Yang
Uzma Hameed
Yi-Liu Xu
ResearchOpen Access20 Jan 2017
Scientific Reports

Volume: 7, P: 1-8
Machine learning based early warning system enables accurate mortality risk prediction for COVID-19

Methods to stratify patients according to mortality risk are essential to allocate limited heath resources during the COVID-19 crisis. Here, using machine learning methods, the authors present a mortality risk prediction model for COVID-19 that uses patients’ clinical data on admission to stratify patients by mortality risk.

Yue Gao
Guang-Yao Cai
Qing-Lei Gao
ResearchOpen Access06 Oct 2020
Nature Communications

Volume: 11, P: 1-10
Establishment of a forward primers-superposed amplification analysis for accurate aspirin pharmacogenomic measurement

Chun-Yan Li
Ping Yang
Wen-Jun Lan
ResearchOpen Access09 Jan 2024
Scientific Reports

Volume: 14, P: 1-7
Effect of septal flash on right ventricular systolic function in left bundle-branch block patients with preserved left ventricular ejection fraction

Guang-yuan Li
Yong-huai Wang
Jun Yang
ResearchOpen Access19 Jul 2017
Scientific Reports

Volume: 7, P: 1-8
Transforming ground mica into high-performance biomimetic polymeric mica film

Biomimetic assembly of nanosheets into nacre-like structures and films is of interest for a range of applications; the abundance of mica makes it a good candidate. Here, the authors report on the large-scale exfoliation of ground mica into nanosheets and the assembly into polymeric mica films.

Xiao-Feng Pan
Huai-Ling Gao
Shu-Hong Yu
ResearchOpen Access30 Jul 2018
Nature Communications

Volume: 9, P: 1-8
Antibacterial anthraquinone derivatives isolated from a mangrove-derived endophytic fungus Aspergillus nidulans by ethanol stress strategy

Sui-Qun Yang
Xiao-Ming Li
Bin-Gui Wang
Research01 May 2018
The Journal of Antibiotics

Volume: 71, P: 778-784
Simple and rapid detection of Tilletia horrida causing rice kernel smut in rice seeds

Yu Chen
Xue Yang
Tong-Chun Gao
ResearchOpen Access14 Sept 2016
Scientific Reports

Volume: 6, P: 1-8
A novel crosstalk between BRCA1 and sirtuin 1 in ovarian cancer

Da Li
Fang-Fang Bi
Qing Yang
ResearchOpen Access17 Oct 2014
Scientific Reports

Volume: 4, P: 1-7
Sensory involvement in the SOD1-G93A mouse model of amyotrophic lateral sclerosis

Yan-Su Guo
Dong-Xia Wu
Chun-Yan Li
ResearchOpen Access31 Mar 2009
Experimental & Molecular Medicine

Volume: 41, P: 140-150
Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population

Qing Wang and colleagues report a genome-wide association study for coronary artery disease (CAD) in a Chinese Han population. They identify a locus on chromosome 6p24.1 newly associated with CAD.

Fan Wang
Cheng-Qi Xu
Qing K Wang
Research06 Mar 2011
Nature Genetics

Volume: 43, P: 345-349
Transcriptomics-based investigation of manganese dioxide nanoparticle toxicity in rats’ choroid plexus

Chun-Yan Meng
Xin-Yi Ma
Fu-Min Feng
ResearchOpen Access25 May 2023
Scientific Reports

Volume: 13, P: 1-12
Association between dietary inflammatory index and Parkinson’s disease: a prospective study of 165,531 UK biobank participants

Chen-wei Hao
Dong-rui Ma
Chang-he Shi
ResearchOpen Access25 Jul 2025
Scientific Reports

Volume: 15, P: 1-10
Effect of Porphyromonas gingivalis PrtC on cytokine expression in ECV304 endothelial cells and its level in subgingival plaques from patients with chronic periodontitis

Yan-min Wu
Li-li Chen
Zhi-yuan Gu
Research01 Jul 2007
Acta Pharmacologica Sinica

Volume: 28, P: 1015-1023
Granulocyte-macrophage colony-stimulating factor DNA prime-protein boost strategy to enhance efficacy of a recombinant pertussis DNA vaccine

Qing-tian Li
Yong-zhang Zhu
Xiao-kui Guo
Research01 Nov 2006
Acta Pharmacologica Sinica

Volume: 27, P: 1487-1494
New chlorinated xanthone and anthraquinone produced by a mangrove-derived fungus Penicillium citrinum HL-5126

Ke-Yao He
Cheng Zhang
Guang-Ying Chen
Research03 May 2017
The Journal of Antibiotics

Volume: 70, P: 823-827
BCL11B suppresses tumor progression and stem cell traits in hepatocellular carcinoma by restoring p53 signaling activity

Wen-Jing Yang
Yun-Fan Sun
Wei Guo
ResearchOpen Access22 Oct 2020
Cell Death & Disease

Volume: 11, P: 1-13
Linear and nonlinear thermoelectric transport in a quantum spin Hall insulators coupled with a nanomagnet

Rui Wang
Hui Liao
Ning-Xuan Yang
ResearchOpen Access14 Jul 2022
Scientific Reports

Volume: 12, P: 1-9
Oocyte aneuploidy rates in river and swamp buffalo types (Bubalus bubalis) determined by Multi-color Fluorescence In Situ Hybridization (M-FISH)

Alfredo Pauciullo
Carmine Versace
Jiang-Hua Shang
ResearchOpen Access19 May 2022
Scientific Reports

Volume: 12, P: 1-9
Macrophages mediate psoriasis via Mincle-dependent mechanism in mice

Rui-zhi Tan
Xia Zhong
Li Wang
ResearchOpen Access28 Apr 2023
Cell Death Discovery

Volume: 9, P: 1-13
Bilirubin augments Ca²⁺ load of developing bushy neurons by targeting specific subtype of voltage-gated calcium channels

Min Liang
Xin-Lu Yin
Shan-Kai Yin
ResearchOpen Access27 Mar 2017
Scientific Reports

Volume: 7, P: 1-14
Kaempferide ameliorates cisplatin-induced nephrotoxicity via inhibiting oxidative stress and inducing autophagy

Yan-fei Shao
Bing-bing Tang
Qiao-jun He
Research19 Jan 2023
Acta Pharmacologica Sinica

Volume: 44, P: 1442-1454
Sodium Tanshinone IIA Sulfonate alleviates vascular senescence in diabetic mice by modulating the A20-NFκB-NLRP3 inflammasome-catalase pathway

Wei Wei
Yan-Yan Heng
Xin-Yue Liang
ResearchOpen Access26 Jul 2024
Scientific Reports

Volume: 14, P: 1-16
E3 ubiquitin ligase UBR5 modulates circadian rhythm by facilitating the ubiquitination and degradation of the key clock transcription factor BMAL1

Chun-yan Duan
Yue Li
Guoqiang Xu
Research13 May 2024
Acta Pharmacologica Sinica

Volume: 45, P: 1793-1808
Genetic map construction and QTL analysis of leaf-related traits in soybean under monoculture and relay intercropping

Dai-Ling Liu
Si-Wei Chen
Xiao-Ling Wu
ResearchOpen Access25 Feb 2019
Scientific Reports

Volume: 9, P: 1-11
Inhibition of the CEBPβ-NFκB interaction by nanocarrier-packaged Carnosic acid ameliorates glia-mediated neuroinflammation and improves cognitive function in an Alzheimer’s disease model

Wang Yi-Bin
Li Xiang
Wang Chun-Yan
ResearchOpen Access07 Apr 2022
Cell Death & Disease

Volume: 13, P: 1-18
Construction of an anchoring SSR marker genetic linkage map and detection of a sex-linked region in two dioecious populations of red bayberry

Yan Wang
Hui-Min Jia
Zhong-Shan Gao
ResearchOpen Access01 Apr 2020
Horticulture Research

Volume: 7, P: 1-9
Microbiota prevents cholesterol loss from the body by regulating host gene expression in mice

Chun-Yan Zhong
Wei-Wei Sun
Zhi-Yuan Song
ResearchOpen Access27 May 2015
Scientific Reports

Volume: 5, P: 1-12
Natural products: potential treatments for cisplatin-induced nephrotoxicity

Chun-yan Fang
Da-yong Lou
Qin-jie Weng
ReviewsOpen Access09 Mar 2021
Acta Pharmacologica Sinica

Volume: 42, P: 1951-1969
Epstein–Barr virus facilitates the malignant potential of immortalized epithelial cells: from latent genome to viral production and maintenance

Jian-Hong Lu
Yun-Lian Tang
Gui-Yuan Li
Research07 Dec 2009
Laboratory Investigation

Volume: 90, P: 196-209

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