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DNA repair-deficient tumours are eligible for effective targeted therapies, but reliable diagnostic strategies based on functional assays are needed. Here the authors develop methods for the rapid assessment of homologous recombination and mismatch repair status in tumor tissues, allowing drug efficacy to be predicted.

Endometriosis is a major cause of infertility. Molecular mechanisms underlying the disease involve genetic and environmental risk factors. In a meta-analysis of eleven GWA studies, Sapkota and colleagues identify five novel risk loci, implicating steroid sex hormone pathways in the pathogenesis.

In cuprates, superconductivity exists in a narrow window at high electron doping concentration with strong antiferromagnetic correlations. Here, the authors demonstrate superconductivity with no effect of antiferromagnetic order in a cuprate for a wide electron doping range following a protect anneal process.

The spin Seebeck effect, which refers to a spin current induced by a temperature gradient, is experimentally well established but a comprehensive theoretical framework is still missing. Here the authors succeed in explaining the non-locality and in predicting a non-magnon origin of the effect.

Wildfires release a large amount of solid-state, highly absorptive brown carbon particles that affect Earth’s radiation budget. About 50% of these particles can take up water, and organic or water coatings further increase their sunlight absorption.

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Dermatoscopy is a common method to aid in diagnosis of melanoma, however, its utility in predicting metastasis is not fully known. Here, the authors leverage a cohort of 30 dermatologists to develop models to predict prognosis from dermatoscopic images.

Lead halide-based quasi-two-dimensional perovskite films with different organic cations are used to create stable green lasers under continuous-wave optical pumping in air at room temperature.

The development of exciplex-type hosts for thermally activated delayed fluorescence organic light-emitting diodes is hindered by a lack of structural information for these donor:acceptor blends. Here, the authors report the pump-probe Step-Scan Fourier transform IR spectra for a D:A exciplex host.

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

By using phylogenetic analyses of multiple microdissected samples from both cancer and non-cancer lesions, unique evolutionary histories of breast cancers harbouring a common driver alteration are shown, providing new insight into how breast cancer evolves.

Adachi et al. describe a mechanism of adaptive resistance to KRAS G12C inhibitors which involves a Scribble mis-localization via palmitoylation and subsequent YAP and MRAS activation that leads to feedback reactivation of MAPK signaling.

Immunoselection underpins tumor antigenic variability and is a key impediment to adoptive cell therapies. Darcy, Beavis and colleagues use T cells engineered to express the dendritic cell growth factor Flt3L to co-opt the host endogenous adaptive immune response and control experimental tumor models.

Direct visualization of the motion of long-lived charge-transfer states in an organic blend reveals that bound electron–hole pairs stretch and contract, and diffuse more than 10 nm before they dissociate or recombine.

Dale Nyholt and colleagues report a genome-wide association meta-analysis of endometriosis in individuals of Japanese and European ancestry. They report a new susceptibility locus at 12q22 and establish an association at 2p25.1.

Iron-based superconductors are promising for its use in building superconducting magnets; however, their high-field critical current density needs to be improved. Miura et al. show that this can be achieved with a one-step growth process that uniformly incorporates BaZrO₃ nanoparticles into BaFe₂As₂films.

To date, lasing in colloidal quantum dot solids has been limited to the nanosecond temporal range, limiting the potential for solution-processed lasers. Here, the authors combine thermal management with low amplified spontaneous emission threshold to produce microsecond-sustained lasing.

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Thermally activated delayed fluorescence organic light-emitting diodes (TADF-OLEDs) rely on high triplet energy interlayers to confine excitons, which results in reduced performance. Here, the authors report high-performance blue TADF-OLEDs with below bandgap electroluminescence.

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Atlasi et al. demonstrate that transcriptome and epigenome resetting during serum-to-2i pluripotency conversion involves minimal enhancer–promoter rewiring and is instead linked to 2i-enhancer activation via Esrrb-mediated H3K27 acetylation.

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

The disposal of PTFE and PFAS poses major environmental concerns. Here, the authors demonstrate their efficient defluorination at room temperature using sodium dispersion, converting these persistent pollutants into recoverable sodium fluoride.

Effective energy transfer and suppressed dopant aggregation is critical for realizing efficient organic light-emitting diodes. Here, the authors report six host materials capable of exhibiting enhanced thermal stability and film-formation behavior, demonstrating efficiency of over 30% at 1000 cd/m².

How do cells of the preimplantation mouse embryo make decisions? Here the authors discovered that the spatial sorting of mRNAs, tRNA, rRNAs and organelles lead to localized translation, conducive for cell fate allocation and embryonic development.

Despite being a promising soft material embodied by molecular self-assembly, the formation mechanism of supramolecular gels remains challenging to fully understand. This study describes a block-stacking model to provide molecular and nanoscopic insights.

The authors identify V-161, a compound that inhibits enterococcal Na⁺-V-ATPase and reduces VRE colonization in mice. The high-resolution structure of V-161 reveals its action on the Na+ transport pathway, offering new therapeutic insights.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.