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An optically coupled Bose–Einstein condensate of potassium atoms is used to engineer chiral interactions and perform the quantum simulation of a one-dimensional reduction of the topological Chern–Simons gauge theory.

How adhesive forces are transduced and integrated into biochemical signals at focal adhesions (FAs) is poorly understood. Here authors show that force- FAK signaling coupling coordinates cell migration and tissue-scale forces to promote microtissue repair.

Human mobility studies established that a high degree of predictability coexists with the variability of individual mobility. Here, the authors, by looking at mobile phone and GPS data, identify and model the emergence of two classes of mobility patterns in humans, returners and explorers.

Intracellular recording involves puncturing the cell membrane to gain access to the cell. In this work, the authors introduce a puncture-free intracellular recording approach that leverages a deep learning model to translate extracellular recordings into intracellular signals.

Here, the authors report the observation of two solid-state analogues of well-known high-energy physics effects in graphene samples irradiated by infrared photons under non-equilibrium conditions. Depending on the carrier density of graphene, they observed asymmetric plasmon damping, and anomalous photocurrents associated with the condensed matter versions of the Cherenkov and Schwinger effects.

Communities of microbes play important roles in natural environments and hold great potential for deploying division-of-labor strategies in synthetic biology and bioproduction. Here, in a community of two competing E. coli strains, the authors show that the relative abundances of the strains can be stabilized and steered dynamically with remarkable precision by coupling the cells to an automated computer-controlled feedback-loop.

The intrinsic dynamics of neurons, in particular the generation action potentials, can impact neural network states and processes of encoding information. The authors demonstrate how the elevation of temperature induces a type of action potential dynamics that favors synchronization patterns in neural networks.

Scientists theoretically show infrared to X-ray sources that can be implemented on-chip by scattering high-energy electrons with graphene plasmons and predict that they are capable of producing tunable radiation.

Microbes drive the Earth’s biogeochemical cycles. Here, Li et al. present a framework for integrating genome-inferred microbial kinetic traits into ecosystem mechanistic models, and use it to benchmark predictions against observed greenhouse gas emissions at an Arctic wetland.

Carbonaceous chondrites are amongst the most chemically primitive solid materials in the Solar System. Here, the authors reports enrichments in heavier zinc isotopes in heated carbonaceous chondrites compared to the typical ranges for chondritic meteorites.

Borcoman and colleagues present the efficacy and safety results of the phase 2 PEVOsq basket trial investigating the combination of pembrolizumab with the epidrug vorinostat in patients with recurrent and/or metastatic squamous cell carcinoma.

An analysis of crater morphologies on 433 Eros reveals that the 16 km near-Earth asteroid has a highly dissipative interior. These results show that, contrary to the established view, even the largest near-Earth asteroids may be rubble piles.

The success of HER2-targeted cancer therapy is limited by treatment resistance. Here, the authors engineer an anti-HER2 biparatopic antibody with multiple mechanisms of action including induction of HER2 clustering to trigger complement dependent cytotoxicity, signal inhibition, antibody dependent cellular cytotoxicity and phagocytosis.

Although theory indicates that deception and punishment are successful social strategies, there is little evidence for either in the wild. This study presents the first systematic evidence of tactical deception and punishment of reproductive cheating in a wild primate, the gelada (Theropithecus gelada).

The bankruptcy of 23andMe was an inflection point for the direct-to-consumer genetics market. Although the privacy of consumer data has been highlighted by many as a concern, we discuss another key tension in this case: the corporate enclosure of scientific data that has considerable potential value for biomedical research and public health.

Effective antivirals are critical for combatting SARS-CoV-2 infections. Here, the authors develop two orally available small molecules, which specifically inhibit the activity of the SARS-CoV-2 main protease and potently block the infectivity and replication of various SARS-CoV-2 strains in cells and mice.

Paediatric high-grade gliomas with MYCN amplification (HGG-MYCN) are rare and highly aggressive. Here, the authors generate a mouse model for HGG-MYCN that can recapitulate the histological and molecular profiles of the human tumours, and perform high-throughput drug screening to identify potential treatment options.

Quantum systems possessing conserved quantities are expected to show quantum fluid properties governed by hydrodynamic equations. This behaviour is now evidenced in a neutron scattering study on the one-dimensional Heisenberg antiferromagnet KCuF₃.

Asteroids Ryugu and Bennu have been linked to collisional families in the main belt, but their surface ages suggest younger parents than their putative families. Here, the authors show numerical simulations that suggest these asteroids are likely remnants of later disruptions of original family members.

The transduction of signals by c-Jun N-terminal kinases (JNK) is highly contextual and has diverse cell functions. Here, the authors reveal tiered kinases in the JNK pathway are regulated by intracellular pH with changed signaling outcomes.

Modelling of the evolution of atmospheric methane emissions from the 2022 Nord Stream subsea pipeline leaks shows that the event emitted the largest recorded amount of methane from a single transient event.

Real-time prediction of dynamics for complex physical systems governed by partial differential equations is challenging and computationally expensive. The authors propose a framework for learning neural operators in latent spaces that allows real-time predictions of high-dimensional nonlinear systems.

Cholesterol metabolism is altered in amyotrophic lateral sclerosis. The authors show that promoting cellular cholesterol excretion in a mouse model improves myelination, reduces the disease-associated oligodendrocyte response, and prolongs survival.

CLPB is a protein disaggregase that has been linked to human disease. Here, the authors show that in different models of chronic or acute loss of the mitochondrial disaggregase, mitochondrial Ca²⁺ handling and fusion dynamics are impaired, revealing their dependence on CLPB.

Goel et al. examine why some factually correct news articles are often shared by users who also shared fake news articles on social media.

Water use may be a topic of increased research, but water theft remains understudied. This paper utilizes insights from three international case studies to inform on the systemic failures that sustain water theft.

In situ experimental findings from six contrasting oceanic regimes, at multiple mesopelagic depths, are used to determine the mechanisms that drive microbially mediated carbon flux attenuation in the oceanic biological pump.

Understanding the keyhole porosity formation is important in laser powder bed fusion. Here the authors reveal the dynamics of keyhole fluctuation, and collapse that induces bubble formation with three main stages of evolution; growth, shrinkage, and being captured by the solidification front.

The authors present a characterization of complex X-linked lncRNA loci with sex- and allele-specific epigenetic signatures that serve as a platform for the largest chromatin structures in mammals, thereby elucidating diverse phenotypes and combinatorial effects on autosomes.

Schooling or flocking of animals in nature is generally explained via an energy optimization approach. Here, Beckeret al. mimic the conditions for an infinite array of swimmers in a water tank and show that fluid dynamic interactions alone are sufficient to lead to coherent and collective locomotion.

Secco et al. develop a genetic tracing method, CycleTrack, to monitor cardiac regeneration. CycleTrack visualizes cardiomyocyte turnover in neonatal and adult mice, after myocardial infarction, and upon stimulation with pro-regenerative microRNAs.

The authors combine biologically-inspired learning techniques with neuromorphic hardware to implement an energy-efficient system that demonstrates rapid learning of unseen tasks across various domains.

The usual treatment of wave scattering theory relies on a formalism that does not easily allow for probing optimal spectral response. Here, the authors show how an alternative formalism, encoding fundamental principles of causality and passivity, can be used to make sense of complex scattered fields’ structures.