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In the Spitzer Space Telescope’s 16 years of operation, it observed many Solar System objects and environments. In this first Review Article of a pair, Spitzer’s insights into comets, centaurs and Kuiper belt objects—all remnants of the Solar System’s formation—are summarized.

The Spitzer Space Telescope launched when the study of exoplanets was in its infancy, and yet it was remarkably successful in characterizing both exoplanet and brown dwarf systems through their mid-infrared emissions. This Review collates the highlights of Spitzer-based research in these fields.

In the Spitzer Space Telescope’s 16 years of operation, it observed many Solar System objects and environments. In this second Review Article of a pair, Spitzer’s insight into asteroids, dust clouds and rings and the ice giant planets are summarized.

A nine-year transit-timing campaign has measured the extremely low masses and densities of four large planets orbiting the young star V1298 Tau, which are now predicted to contract and form a typical compact super-Earth and sub-Neptune system.

A comprehensive study of the Kepler-138 system reveals the twin nature of Kepler-138 c and d and the presence of a fourth planet. Remarkably, the warm-temperate planet Kepler-138 d is probably composed of 50% volatiles by volume, indicative of a water world, rather than a rocky world, despite its small ~1.5 R_⊕ size.

A giant planet candidate roughly the size of Jupiter but more than 14 times as massive is observed by TESS and other instruments to be transiting the white dwarf star WD 1856+534.

The authors report on a temperate Earth-sized planet orbiting the cool M6 dwarf LP 791-18 with a radius of 1.03 ± 0.04 R_⊕ and an equilibrium temperature of 300–400 K, with the permanent night side plausibly allowing for water condensation.

Brown dwarfs are small stars that are believed to be made of a warm dense plasma that cannot support hydrogen fusion as larger stars do. Here, the authors present a method for studying the properties, such as resistivity, of warm dense plasmas in the laboratory.

Space telescope observations of the transmission spectrum of the extrasolar planet HAT-P-11b, which is about the same size as Neptune, reveal water vapour absorption at a wavelength of 1.4 micrometres and indicate that the planetary atmosphere is predominantly clear down to an altitude corresponding to about 1 millibar.

A transiting planet with a period of about 8.5 days and a radius 0.4 times that of Jupiter is reported within the debris disk around the star AU Microscopii.

We report on JWST images of a temperate super-Jupiter in the system Epsilon Ind A—a K5V star at a distance of just 3.6 pc—in the mid-infrared.

Kinematic measurements of the Perseus galaxy cluster reveal two drivers of gas motions: a small-scale driver in the inner core associated with black-hole feedback and a large-scale driver in the outer core powered by mergers.

By day 1,041 after explosion, SN Ia-CSM 2018evt had produced an estimated 0.01 solar masses of dust in the cold, dense shell behind the supernova ejecta–circumstellar medium interaction, ranking it as one of the most prolific dust-producing supernovae ever recorded.

A comprehensive set of Hubble and Spitzer observations reveal a hydrogen-rich, low-metallicity atmosphere on the sub-Neptune exoplanet GJ 3470 b. Water vapour is detected, but the planet is surprisingly depleted in methane, possibly because of photochemical or thermal processes. Sub-millimetre-sized Mie-scattering cloud particles partially attenuate the molecular signatures at short wavelength, but are largely transparent beyond 3 µm.

 Observations with the sensitive mid-infrared spectrometer MIRI on board JWST reveal the presence of a water vapour reservoir in the terrestrial plant-forming zone of the young planetary system PDS 70.

This pilot trial showed that perioperative treatment with the isocitrate dehydrogenase (IDH) inhibitor safusidenib of patients with low-grade IDH-mutant glioma, with craniotomy and lumbar puncture before and after treatment, is feasible and safe and enabled in-depth translational investigation of safusidenib treatment-induced changes in the tumor, including electrophysiological effects.

The luminosity of ultraviolet light emitted by the first galaxies in the universe traces the formation and evolution of stars and galaxies which led to the epoch of reionization. Here the authors use data from the Hubble Space Telescope and through a model provide a bound for the total luminosity.

Last year, three Earth-sized planets were discovered to be orbiting the nearby Jupiter-sized star TRAPPIST-1; now, follow-up photometric observations from the ground and from space show that there are at least seven Earth-sized planets in this star system, and that they might be the right temperature to harbour liquid water on their surfaces.

Laboratory spectra of dust/ice aggregates are comparable to those observed in astrophysical environments, questioning the traditional onion-like layered ice model. According to observational spectra, such icy mixtures could harbour water ice in the diffuse interstellar medium, as well as in low-temperature circumstellar environments.

Transmission spectroscopy observations from the James Webb Space Telescope show the detection of carbon dioxide in the atmosphere of the gas giant exoplanet WASP-39b.

An unusual ultraviolet compact object associated with a dusty starburst has been observed at a redshift of about 7.2, with a luminosity that falls between that of quasars and galaxies, possibly in transition between the two. 

Using terahertz spectroscopy and ultrafast electron diffraction, the paper shows how the DC conductivity of warm dense matter depends on material phase. This provides insight to how electron scattering processes impact conductivity in this regime.

Infrared spectroscopy can probe the conditions and compositions of exoplanet atmospheres. Previous results relied on space-based telescopes that do not provide spectroscopic capability in the 2.4–5.2 μm spectral region. Here, ground-based observations of the dayside emission spectrum for HD 189733b are reported between 2.0–2.4 μm and 3.1–4.1 μm; an unexpected feature at around 3.25 μm is found that is difficult to explain with models that assume local thermodynamic equilibrium conditions, and is assigned to methane.

Orbital parameters for the seventh Earth-sized transiting planet around star TRAPPIST-1 are reported, along with an investigation into the complex three-body resonances linking every member of this planetary system.

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

A rapidly growing black hole in a very active phase has been observed with JWST ~1.5 billion years after the Big Bang. Bright in X-rays, it is accreting at a rate 4,000% in excess of the Eddington limit, offering insights into early black hole growth.

The dayside thermal emission spectrum and brightness temperature map of the ultra-hot Jupiter WASP-18b obtained from the NIRISS instrument on the JWST showed water emission features, an atmosphere consistent with solar metallicity, as well as a steep and symmetrical decrease in temperature towards the nightside.

Integrated single-cell transcriptomic and genetic characterization of 121 adult glioblastomas identifies heterogeneity at cell type, cell state and baseline expression program levels associated with specific mutations that form three stereotypical ecosystems.

The most distant quasars known, at redshifts z ≈ 6, generally have the same properties as lower-redshift quasars, implying that although the Universe was young at z ≈ 6, such quasars are still evolved objects. One z ≈ 6 quasar was shown to have no detectable emission from hot dust, but it was not clear whether it was an outlier. Now, a second quasar without hot-dust emission has been discovered in a sample of 21 z ≈ 6 quasars. Moreover, hot-dust abundance in these quasars builds up as the central black hole grows.

Saturn-mass exoplanet HD 149026b has an atmospheric metallicity 59–276 times solar, which is greater than Saturn’s atmospheric metallicity of roughly 7.5 times solar and more correlated with bulk metallicity than planet mass.

Using JWST, the molecules seen in planetary atmospheres can be traced back to their cold origins in ices formed in dense interstellar clouds, before the onset of star formation, revealing that chemical diversity and complexity is achieved early.

Phase-resolved mid-infrared observations from JWST of the hot gas giant WASP-43b detect a day–night difference of 659 ± 19 K. Comparison with climate models shows that the observations are compatible with cloudy skies, at least on the nightside, and the lack of methane detection suggests the presence of disequilibrium chemistry.

In the Solar System, planetary rings tend to lie within a few radii of their host body, because at these distances gravitational accelerations inhibit satellite formation. One of the best known exceptions to this rule is Saturn's E ring, a broad sheet of dust continuously supplied by source satellites that fades from view at five to ten planetary radii. An enormous ring associated with Saturn's outer moon Phoebe is now reported; it extends from at least 128 to 207 Saturn radii.

The hydroxyl radical OH has been detected in a planet-forming disk exposed to ultraviolet radiation and in a rovibrationally excited state. These JWST observations, when coupled with quantum calculations, reveal the ongoing photodissociation of water and its reformation in the gas phase.

A spectroscopic comparison of ten hot-Jupiter exoplanets reveals that the difference between the planetary radius measured at optical and infrared wavelengths allows atmosphere types ranging from clear to cloudy to be distinguished; the difference in radius at a given wavelength correlates with the spectral strength of water at that wavelength, suggesting that haze obscures the signal from water.

A complete revolution of exo-Neptune LTT 9779 b was observed with the NIRISS/SOSS instrument onboard the JWST. The resulting full phase curve is indicative of an equatorial jet that transports heat from the dayside to the colder nightside, resulting in an asymmetric distribution of clouds on the planet.

Using spatial transcriptomics, this study profiled the expression of hundreds of matrisome genes at single-cell resolution in human brain tumors, revealing targetable adhesion and signalling components in glioblastoma and lower-grade gliomas.

A longitudinal thermal brightness map of the super-Earth exoplanet 55 Cancri e reveals strong day–night temperature contrast, indicating inefficient heat redistribution consistent with 55 Cancri e either being devoid of atmosphere or having an optically thick atmosphere with heat recirculation confined to the planetary dayside.

Global circulation theory predicts strong equatorial jets at the equators of hot gas giant exoplanets that blow hot gas to the east, resulting in an eastward hotspot. Here, Dang et al. present a detection of a hotspot significantly offset to the west.

This paper reports the discovery of an infrared elliptical ring or shell surrounding the magnetar SGR 1900+14. It is suggested that a dust-free cavity was produced in the magnetar environment by the giant flare emitted by the source in August 1998 and concludes that SGR 1900+14 is unambiguously associated with a cluster of massive stars.

Phase curve measurements for the small (1.3 Earth radii) terrestrial exoplanet LHS 3844b show absence of a thick atmosphere, in agreement with theoretical predictions.

Hubble Space Telescope, Keck telescope and Spitzer satellite data reveal the formation of the dense stellar core of a massive galaxy occurring three billion years after the Big Bang.