Nature Search

Single-cell spatial transcriptomic analysis of human skin anatomy

This study presents an organ-wide spatial transcriptomic analysis of human skin from different anatomical sites using a combination of MERFISH technology and existing datasets from healthy and diseased skin.

Paula Restrepo
Alexis Wilder
Andrew L. Ji
ResearchOpen Access23 Mar 2026
Nature Genetics

P: 1-13
Targeting NHEJ activates STING signaling through MYC degradation to boost antitumor immunity in SCLC

Small-cell lung cancer (SCLC) is a highly aggressive cancer type with immunosuppressed phenotype. Here, the authors find that depletion of nonhomologous end joining DNA repair regulator PRKDC is able to induce activation of the cGAS/STING pathway and potentiate the efficacy of immunotherapy in SCLC pre-clinical models.

Subhamoy Chakraborty
Andrew Elliott
Triparna Sen
ResearchOpen Access10 Feb 2026
Nature Communications

Volume: 17, P: 1-23
Spinning continents

Dan McKenzie
News & Views08 Mar 1990
Nature

Volume: 344, P: 109-110
A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma

The changes in super-enhancer (SE) landscape of cancers are mainly attributed to cell-intrinsic genomic alterations. Here, the authors perform epigenomic profiling on primary colorectal cancers (CRCs) and their matched normal tissues and show that local tumour microenvironment induces a SE activation and that its target, PDZK1IP1 promotes CRC growth.

Royce W. Zhou
Jia Xu
Ramon E. Parsons
ResearchOpen Access17 Oct 2022
Nature Communications

Volume: 13, P: 1-17
Lymphoid gene expression supports neuroprotective microglia function

PU.1^low CD28-expressing microglia may act as suppressive cells in Alzheimer’s disease, mitigating its progression by reducing neuroinflammation and amyloid plaque load, indicating potential immunotherapeutic approaches for treatment.

Pinar Ayata
Jessica M. Crowley
Anne Schaefer
ResearchOpen Access05 Nov 2025
Nature

Volume: 648, P: 157-165
RAS-mutant leukaemia stem cells drive clinical resistance to venetoclax

We find that RAS-mutant leukaemia stem cells are resistant to venetoclax, driving clinical resistance and relapse with monocytic features.

Junya Sango
Saul Carcamo
Eirini P. Papapetrou
ResearchOpen Access30 Oct 2024
Nature

Volume: 636, P: 241-250
Correction: Corrigendum: MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency

Alexandre Gaspar-Maia
Zulekha A. Qadeer
Emily Bernstein
Amendments and Corrections29 Aug 2013
Nature Communications

Volume: 4, P: 1
The octamer is the major form of CENP-A nucleosomes at human centromeres

Centromere protein A (CENP-A) is a histone H3 variant that specifies centromere location, but the histone composition and stoichiometry of CENP-A nucleosomes have been controversial. ChIP-seq and biochemical analyses of in vitro–reconstituted CENP-A nucleosomes now demonstrate that the predominant form at functional centromeres is an octamer with loose DNA ends.

Dan Hasson
Tanya Panchenko
Ben E Black
Research05 May 2013
Nature Structural & Molecular Biology

Volume: 20, P: 687-695
MacroH2A restricts inflammatory gene expression in melanoma cancer-associated fibroblasts by coordinating chromatin looping

Filipescu et al. report that macroH2A deficiency in cancer-associated fibroblasts leads to altered chromatin looping and elevated inflammatory gene expression, thereby affecting immune cell function and limiting the anti-tumour response in melanoma.

Dan Filipescu
Saul Carcamo
Emily Bernstein
ResearchOpen Access21 Aug 2023
Nature Cell Biology

Volume: 25, P: 1332-1345
Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer

Oncofetal (OnF) reprogramming, driven by YAP and AP-1, induces phenotypic plasticity and therapy resistance in WNT-dependent colorectal cancer (CRC). Targeting the OnF state in combination with chemotherapy substantially attenuates tumor growth in mouse models and patient-derived CRC tumoroids.

Slim Mzoughi
Megan Schwarz
Ernesto Guccione
ResearchOpen Access10 Feb 2025
Nature Genetics

Volume: 57, P: 402-412
Foraging postures are a potential communicative signal in female bonobos

Elisa Demuru
François Pellegrino
Florence Levréro
ResearchOpen Access24 Sept 2020
Scientific Reports

Volume: 10, P: 1-7
MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency

Chromatin templates can act as barriers against cellular reprogramming. Gaspar-Maia and colleagues use mouse models deficient in the histone variants macroH2A1 and macroH2A2, and find that macroH2A functions as an epigenetic barrier against induced pluripotency by silencing Utx target genes.

Alexandre Gaspar-Maia
Zulekha A. Qadeer
Emily Bernstein
Research05 Mar 2013
Nature Communications

Volume: 4, P: 1-13
PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis

The transcriptional regulator PRDM15 is expressed at low levels in normal tissues but overexpressed in B-cell lymphomas. Here, the authors show that PRDM15 depletion does not affect adult somatic cell homeostasis but leads to a metabolic crisis which impairs B-cell lymphomagenesis.

Slim Mzoughi
Jia Yi Fong
Ernesto Guccione
ResearchOpen Access14 Jul 2020
Nature Communications

Volume: 11, P: 1-14
WNTinib is a multi-kinase inhibitor with specificity against β-catenin mutant hepatocellular carcinoma

Guccione and colleagues identify and characterize a sorafenib derivative, WNTinib, with therapeutic efficacy in β-catenin-mutated hepatocellular carcinoma and identify EZH2 as important for the activity of the inhibitor.

Alex Rialdi
Mary Duffy
Arvin C. Dar
Research03 Aug 2023
Nature Cancer

Volume: 4, P: 1157-1175
Histone H3.3 and its proteolytically processed form drive a cellular senescence programme

Cellular senescence involves extensive structural changes to chromatin, but the role of histone variants and histone cleavage is unknown. Here, Duarte et al.identify histone variant H3.3 and its proteolytically processed form lacking a portion of the N-terminal tail as key regulators of senescence.

Luis F. Duarte
Andrew R. J. Young
Emily Bernstein
Research14 Nov 2014
Nature Communications

Volume: 5, P: 1-12
SIRT6 haploinsufficiency induces BRAF^V600E melanoma cell resistance to MAPK inhibitors via IGF signalling

The epigenetic mechanisms of melanoma drug resistance are poorly understood. Here, the authors develop a CRISPR-Cas9 screen targeting epigenetic regulators and discover that SIRT6 haploinsufficiency induces BRAF^V600E melanoma cell resistance to MAPK inhibitors via IGF signalling.

Thomas Strub
Flavia G. Ghiraldini
Emily Bernstein
ResearchOpen Access24 Aug 2018
Nature Communications

Volume: 9, P: 1-13
Author Correction: A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma

Royce W. Zhou
Jia Xu
Ramon E. Parsons
Amendments and CorrectionsOpen Access06 Apr 2023
Nature Communications

Volume: 14, P: 1
A common flanking variant is associated with enhanced stability of the FGF14-SCA27B repeat locus

Analysis of the FGF14-SCA27B repeat locus identifies a common 5′-flanking insertion that represents the major allele, is present exclusively on nonpathogenic alleles, enhances repeat stability and increases chromatin accessibility.

David Pellerin
Giulia F. Del Gobbo
Matt C. Danzi
Research27 Jun 2024
Nature Genetics

Volume: 56, P: 1366-1370
Transcription-associated histone pruning demarcates macroH2A chromatin domains

Histone variant macroH2A is initially pervasively deposited across the mouse genome and is subsequently selectively evicted from transcriptionally active regions to establish macroH2A chromatin domains.

Zhen Sun
Dan Filipescu
Emily Bernstein
Research05 Oct 2018
Nature Structural & Molecular Biology

Volume: 25, P: 958-970
SETDB1 is critically required for uveal melanoma growth and represents a promising therapeutic target

Imène Krossa
Céline Pisibon
Thomas Strub
ResearchOpen Access24 Oct 2025
Cell Death & Disease

Volume: 16, P: 1-17
MacroH2A histone variants modulate enhancer activity to repress oncogenic programs and cellular reprogramming

MacroH2A histone variants are shown to mark a subset of enhancers in both normal and cancer cells. In mice, macroH2A deficiency is shown to facilitate increased activity of transcription stem cell-associated transcription factors.

Wazim Mohammed Ismail
Amelia Mazzone
Alexandre Gaspar-Maia
ResearchOpen Access23 Feb 2023
Communications Biology

Volume: 6, P: 1-19
Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer

Jodi M. Saunus
Xavier M. De Luca
Sunil R. Lakhani
ResearchOpen Access02 May 2022
npj Breast Cancer

Volume: 8, P: 1-16

Search

Single-cell spatial transcriptomic analysis of human skin anatomy

Targeting NHEJ activates STING signaling through MYC degradation to boost antitumor immunity in SCLC

Spinning continents

A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma

Lymphoid gene expression supports neuroprotective microglia function

RAS-mutant leukaemia stem cells drive clinical resistance to venetoclax

Correction: Corrigendum: MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency

The octamer is the major form of CENP-A nucleosomes at human centromeres

MacroH2A restricts inflammatory gene expression in melanoma cancer-associated fibroblasts by coordinating chromatin looping

Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer

Foraging postures are a potential communicative signal in female bonobos

MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency

PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis

WNTinib is a multi-kinase inhibitor with specificity against β-catenin mutant hepatocellular carcinoma

Histone H3.3 and its proteolytically processed form drive a cellular senescence programme

SIRT6 haploinsufficiency induces BRAF^V600E melanoma cell resistance to MAPK inhibitors via IGF signalling

Author Correction: A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma

A common flanking variant is associated with enhanced stability of the FGF14-SCA27B repeat locus

Transcription-associated histone pruning demarcates macroH2A chromatin domains

SETDB1 is critically required for uveal melanoma growth and represents a promising therapeutic target

MacroH2A histone variants modulate enhancer activity to repress oncogenic programs and cellular reprogramming

Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer

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