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The SIT1-ACE2 complex transports the amino acid proline and is the receptor of SARS-CoV-2. Here, the authors identify specific sequence requirements for proline transport and explain for how a missense mutation causes iminoglycinuria.

The proximity effect in semiconductor-superconductor nanowires is expected to generate an induced gap in the semiconductor. Here, the authors study the superconducting proximity effect in InSb nanowires with an Al/Pt shell, demonstrating control of the induced gap using electric and magnetic fields.

Cardiac fibrosis arises from persistent myofibroblast activity. This study reveals how chromatin factors control scar-forming cells in the heart and shows that inhibiting KAT5 can reduce harmful cardiac fibrosis.

Recent experiments have shown the formation of ferroelectric domains in twisted van der Waals bilayers. Here, the authors report near-field infrared nano-imaging and nano-photocurrent measurements to investigate ferroelectricity in minimally twisted WSe₂ by visualizing the plasmonic and photo-thermoelectric response of an adjacent graphene monolayer.

In single-particle cryo-EM, datasets often contain molecules that exist in a heterogeneous mix of states. Here, the authors compare different computational tools to study this heterogeneity and derive metrics to quantitatively compare their results.

Single cell transcriptomics and chromatin accessibility uncover the gene networks underlying planarian cell type differentiation, revealing insights into the combinatorial logic of planarian cell fate specification.

Physical realizations of qubits are often vulnerable to leakage errors, where the system ends up outside the basis used to store quantum information. A leakage removal protocol can suppress the impact of leakage on quantum error-correcting codes.

Filtering or gating relevant information into working memory has been attributed to the striatum. Here, the authors reveal neocortical filtering mechanisms, namely, rapid changes in oscillatory theta networks, that predict fast and flexible human behavior.

Interactions between qubits and defect-related two-level systems in superconducting qubit devices are a major source of noise fluctuations that hinder error-mitigation performance. Here, the authors experimentally show that modulating this interaction can reduce noise fluctuation and improve error mitigation performance.

Understanding of the immune microenvironment in pediatric acute T cell lymphoblastic leukemia is limited. By analyzing single-cell transcriptome, surface protein expression and immune repertoire data, the authors here identify non-malignant CD4^-CD8^- TCRαβ T cells that are present in a subset of patients with Rap1 signaling in leukemia cells and are associated with adverse clinical outcome in patients with low minimal residual disease.

A single electron spin in silicon is dressed by a microwave field to create a new qubit with tangible advantages for quantum computation and nanoscale research.

The authors achieve gate-controlled proximitization of a quantum dot in a planar germanium heterostructure, an isotopically purifiable group IV material. A patterned Pt germanosilicide superconductor is introduced via a thermally activated reaction.

Isotope engineering of silicon carbide leads to control of nuclear spins associated with single divacancy centres and extended electron spin coherence.

A Kitaev chain formed by two quantum dots coupled via a superconductor support the so-called poor man’s Majorana bound states. Here, the authors form a minimal Kitaev chain using Yu-Shiba-Rusinov states and show that the resulting bound states are more robust than in the case of unproximitized quantum dots.

In Vibrio cholerae, a type IVa pilus (T4aP) binds to exogenous DNA, and threads this DNA through the outer membrane secretin, PilQ. Here authors present the cryoEM structure of PilQ from native V. cholerae cells and design a series of mutants to reversibly regulate VcPilQ gate dynamics.

Photovoltaic devices attached to immune cells travel through the blood to inflamed brain regions.

III–V semiconductors are promising platform for qubits, but strong coupling to lattice phonons enhances decoherence of qubit states that have a charge dipole. Here, the authors show that a microwave analogue to the Raman effect can lead to rapid dephasing of qubits based on GaAs double quantum dots.

Strontium titanate two-dimensional electron gas channels that have a thin hafnium oxide barrier layer between the channel and an ionic liquid gate can have ballistic constrictions and clean normal-state conductance quantization.

A new approach is described for fabricating devices on each of the faces of the same gallium nitride semiconductor wafer, using the cation face for photonic devices and the anion face for electronic devices.

The authors develop a computational method to design small DNA-binding proteins (DBPs) that target specific sequences. Designed DBPs show structural accuracy and function in both bacterial and mammalian cells for transcriptional regulation.

Control of the directional photocurrent by polarized light in topological insulators may enable topological spintronics but is not yet well understood. Here the authors demonstrate that the directional photocurrent is due to the asymmetric optical transitions between topological surface states and bulk states.

Here, the authors develop a spectroscopic technique whereby individual defects in an ultrathin hBN dielectric, placed in proximity to graphene, act as quantum dots. Dot-assisted tunneling is highly sensitive to the nearby graphene excitation spectrum, and allows probing of energy splitting in the excited Landau levels.

Direct measurements of the conduction properties of strongly interacting ultracold fermions reveal the well-known drop of resistance associated with the onset of superfluidity.

Electron-electron interactions in many-body systems may manifest themselves through the fractional quantum Hall effect. Here, the authors perform transport measurements in bilayer graphene, and observe particle-hole symmetric fractional quantum Hall states in theN=2 Landau level.

External driving of qubits can exploit their nonlinearity to generate different forms of interqubit interactions, broadening the capabilities of the platform.

GPAT1 is a mitochondrial outer membrane protein that catalyzes the first step of glycerolipid biosynthesis. Cryo-EM structures and functional studies of human GPAT1 uncover the molecular architecture and mechanism of this important acyltransferase.

Operating donor-based quantum computers in silicon is hindered by the dependence of inter-qubit coupling on the precise donor position. Here, the authors show controlled rotation operation on exchange-coupled electron spins in the weak-exchange regime, loosening the requirements on positioning precision.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Qudits, higher-dimensional analogues of qubits, expand quantum state space for information processing using fewer physical units. Here the authors demonstrate control over a 16-dimensional Hilbert space, equivalent to four qubits, using combined electron-nuclear states of a single Sb donor atom in Si.

T cell immunity declines with thymic atrophy, but thymic cell grafts rescue T cell function.

An n-type semiconducting polymer is used to realize an organic electrochemical transistor working as a glucose sensor and an all-polymer enzymatic biofuel cell able to power the sensor itself.

The dynamical axion quasiparticle, which is directly analogous to the hypothetical fundamental axion particle, is observed in two-dimensional MnBi₂Te₄, and has implications for quantum chromodynamics, cosmology and string theory.

Individual electrons trapped on the surface of solid neon can operate as charge qubits with very long coherence times.

Quantum error correction protocols aim at protecting quantum information from corruption due to decoherence and imperfect control. Using three superconducting transmon qubits, Chow et al. demonstrate necessary elements for the implementation of the surface error correction code on a two-dimensional lattice.

The turn-off time is generally faster than the turn-on time in accumulation mode organic electrochemical transistors (OECTs), but the mechanism is less understood. Here the authors find different transient behaviours of turn-on and turn-off in accumulation mode OECTs, and ion transport is the limiting factor of device kinetics.

A dynamical topological phase with edge qubits that are dynamically protected from control errors, cross-talk and stray fields, is demonstrated in a quasiperiodically driven array of ten ¹⁷¹Yb⁺ hyperfine qubits in a model trapped-ion quantum processor.

Free carriers and electrical polarization coexist in ferroelectric metals. Here, the authors use a capacitive method to probe the electronic compressibility of free carriers in a tunable semimetal, extract the polarized contribution, and study the carrier dependence of the ferroelectric state.

Bilayer graphene has been shown to host fractional quantum Hall states. Here, the authors observe the fractional quantum Hall states at quarter- and half-filled Landau levels and the alternation of anti-Pfaffian and Pfaffian phases at half fillings.

Quantum supremacy is demonstrated using a programmable superconducting processor known as Sycamore, taking approximately 200 seconds to sample one instance of a quantum circuit a million times, which would take a state-of-the-art supercomputer around ten thousand years to compute.

Paul and colleagues report the development and characterization of an antibody–drug conjugate targeting TRBC2 for the treatment of T cell malignancies.

Focused-ion beam (FIB) lithography enables high-resolution nanopatterning of 2D materials, but usually introduces significant damage. Here, the authors report a FIB-based fabrication technique to obtain high quality graphene superlattices with 18-nm pitch, which exhibit electronic transport properties similar to those of natural moiré systems.

The presence of various noises in the qubit environment is a major limitation on qubit coherence time. Here, the authors demonstrate the use a closed-loop feedback to stabilize frequency noise in a flux-tunable superconducting qubit and suggest this as a scalable approach applicable to other types of noise.

A three-site Kitaev chain, constructed from three semiconducting quantum dots coupled by superconducting segments in a hybrid InSb/Al nanowire, shows enhanced robustness of edge zero-energy modes against variations in the coupling strengths or electrochemical potentials compared with a chain containing only two quantum dots.

Systematic comparison of genome-wide association results for disease risk and disease-specific mortality for nine common diseases across seven biobanks finds limited overlap between genetic effects on disease susceptibility and survival.

We report superconductivity, in a limited region of displacement field and density, in 5.0° twisted bilayer WSe₂ with a maximum critical temperature of 426 mK, establishing that moiré flat-band superconductivity extends beyond graphene structures.