Nature Search

Global, regional and national burden of ischemic heart disease attributable to suboptimal diet, 1990–2023: a Global Burden of Disease study

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Sooji Lee
Hayeon Lee
Dong Keon Yon
Research30 Mar 2026
Nature Medicine

P: 1-25
Clinicopathologic and molecular predictors of survival in BRCA-deficient tubo-ovarian high-grade serous carcinoma

It remains unclear why some BRCA-deficient high-grade serous carcinomas (HGSC) do not respond to platinum-based therapy. Here, multi-omic analysis of BRCA1- and BRCA2-deficient HGSC attributes co-occurring mutations, DNA repair deficiency and tumor microenvironment features to short survival in these patients.

Tibor A. Zwimpfer
Sian Fereday
Dale W. Garsed
ResearchOpen Access01 Apr 2026
Nature Communications

P: 1-22
Empiric azithromycin alters the upper respiratory microbiome and resistome without anti-inflammatory benefit in COVID-19

Longitudinal metatranscriptomics in a prospective cohort of 1,164 adults hospitalized for COVID-19 reveals that azithromycin offered no apparent anti-inflammatory benefit but enriched the respiratory microbiome with potential pathogens and antimicrobial resistance genes.

Abigail Glascock
Cole Maguire
Charles R. Langelier
ResearchOpen Access16 Mar 2026
Nature Microbiology

P: 1-13
Implementation of the NHS England Lung Cancer Screening Programme over 5 years

Over five years, implementation of the NHS England Lung Cancer Screening Programme achieved high early-stage detection rates and demonstrated that the programme is both feasible and scalable for reaching high-risk and underserved populations.

Richard W. Lee
Arjun Nair
Tim Windle
ResearchOpen Access23 Mar 2026
Nature Medicine

P: 1-10
Systematic analysis of snRNA genes reveals frequent RNU2-2 variants in dominant and recessive developmental and epileptic encephalopathies

Analyses of snRNA genes in a French cohort of people with rare disorders, with validation through international collaboration, identify monoallelic and biallelic variants in RNU2-2 as frequent causes of neurodevelopmental disorders with epilepsy.

Elsa Leitão
Amandine Santini
Caroline Nava
ResearchOpen Access30 Mar 2026
Nature Genetics

P: 1-16
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Contamination of Hodgkin's disease cell cultures

Nancy L. Harris
David L. Gang
Stephen J. O'Brien
Research22 Jan 1981
Nature

Volume: 289, P: 228-230
Genetic modifiers of APOE-ε4-associated cognitive decline

The APOE-ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease, but it is not deterministic. Here, the authors show that common genetic variation changes how APOE-ε4 influences cognition.

Alex G. Contreras
Skylar Walters
Timothy J. Hohman
ResearchOpen Access20 Feb 2026
Nature Communications

Volume: 17, P: 1-17
No lubricants from fluorinated C₆₀

ROGER TAYLOR
ANTHONY G. AVENT
G. JOHN LANGLEY
Research02 Jan 1992
Nature

Volume: 355, P: 27-28
cellSTAAR: incorporating single-cell-sequencing-based functional data to boost power in rare variant association testing of noncoding regions

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

Eric Van Buren
Yi Zhang
Xihong Lin
Research31 Dec 2025
Nature Methods

Volume: 23, P: 338-349
Mitochondrial and chloroplast genomes of maize have a 12-kilobase DNA sequence in common

David B. Stern
David M. Lonsdale
Research21 Oct 1982
Nature

Volume: 299, P: 698-702
Polygenic prediction of body mass index and obesity through the life course and across ancestries

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Roelof A. J. Smit
Kaitlin H. Wade
Ruth J. F. Loos
ResearchOpen Access21 Jul 2025
Nature Medicine

Volume: 31, P: 3151-3168
Direct detection of novel expanded trinucleotide repeats in the human genome

Martin Schalling
Thomas J. Hudson
David E. Housman
Research01 Jun 1993
Nature Genetics

Volume: 4, P: 135-139
Chiral supramolecular assembly to enhance the magneto-optical rotation of organic materials

The relation between magnetooptical activity and chirality has previously been confused. Chiral polymer films are presented with state-of-the-art Verdet constants, revealing the role of chirality, and a strategy to enhance the magnetooptical B term.

Leo Delage-Laurin
David Reger
Matthew J. Fuchter
ResearchOpen Access03 Nov 2025
Nature Communications

Volume: 16, P: 1-7
Neoadjuvant PD-1 blockade in surgically resectable desmoplastic melanoma: cohort A of the phase 2 SWOG S1512 trial

Ribas and colleagues report the results of a phase 2 clinical trial of neoadjuvant PD-1 blockade in patients with surgically resectable desmoplastic melanoma.

Kari L. Kendra
Shay L. Bellasea
Antoni Ribas
ResearchOpen Access29 Jan 2026
Nature Cancer

Volume: 7, P: 272-282
Isolation of a GCC repeat showing expansion in FRAXF, a fragile site distal to FRAXA and FRAXE

Julia E. Parrish
Ben A. Oostra
David L. Nelson
Research01 Nov 1994
Nature Genetics

Volume: 8, P: 229-235
Global burden of amphetamine, cannabis, cocaine and opioid use in 204 countries, 1990–2023: a Global Burden of Disease Study

Global Burden of Disease estimates show that between 1990 and 2023, the prevalence and burden of drug use disorders, inclusive of amphetamine, cannabis, cocaine and opioid use, have been increasing in high-income countries, particularly in the USA.

Jiseung Kang
Hyeon Jin Kim
Dong Keon Yon
Research16 Jan 2026
Nature Medicine

Volume: 32, P: 527-544
Magic numbers and stable structures for fullerenes, fullerides and fullerenium ions

Patrick W. Fowler
David E. Manolopoulos
Research30 Jan 1992
Nature

Volume: 355, P: 428-430
Nanoscale ultrafast lattice modulation with a free-electron laser

Applications of optical laser-based techniques are limited by the long wavelengths of the lasers. Now, observations of phonons and thermal transport at nanometre length scales are reported with an all-hard X-ray transient-grating spectroscopy technique.

Haoyuan Li
Nan Wang
Diling Zhu
Research27 Jan 2026
Nature Physics

Volume: 22, P: 483-488
Ejaculatory abnormalities in mice with targeted disruption of the gene for heme oxygenase-2

Arthur L. Burnett
Devin G. Johns
Kenneth D. Poss
Research01 Jan 1998
Nature Medicine

Volume: 4, P: 84-87
De novo and inherited dominant variants in U4 and U6 snRNA genes cause retinitis pigmentosa

De novo and inherited dominant variants in genes encoding U4 and U6 small nuclear RNAs are identified in individuals with retinitis pigmentosa. The variants cluster at nucleotide positions distinct from those implicated in neurodevelopmental disorders.

Mathieu Quinodoz
Kim Rodenburg
Carlo Rivolta
ResearchOpen Access09 Jan 2026
Nature Genetics

Volume: 58, P: 169-179
Research Objects: Towards Exchange and Reuse of Digital Knowledge

Sean Bechhofer
David De Roure
Iain Buchan
ResearchOpen Access06 Jul 2010
Nature Precedings

P: 1
The observability of possible atmospheric removal processes for chlorfluorocarbons 11 and 12

Robert J. Gelinas
David K. Hall
Robert G. Nelson
Research01 Mar 1977
Nature

Volume: 266, P: 229-231
Reply to: a quantitative trait locus for reduced microglial APOE expression associates with reduced cerebral amyloid angiopathy

Lincoln M. P. Shade
Qi Qiao
David W. Fardo
Research26 Jan 2026
Nature Genetics

Volume: 58, P: 273-274
Release of Hydrocyanic Acid from Crushed Tissues of all Stages in the Life-Cycle of Species of the Zygaeninae (Lepidoptera)

DAVID A. JONES
JOHN PARSONS
MIRIAM ROTHSCHILD
Research06 Jan 1962
Nature

Volume: 193, P: 52-53
Data mining of protein families using common peptides

Assaf Gottlieb
Uri Weingart
David Horn
ResearchOpen Access14 Aug 2008
Nature Precedings

P: 1
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
A saturated map of common genetic variants associated with human height

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Loïc Yengo
Sailaja Vedantam
Joel N. Hirschhorn
ResearchOpen Access12 Oct 2022
Nature

Volume: 610, P: 704-712
Magnetic anisotropy in the electron momentum density of iron

Malcolm J. Cooper
Stephen P. Collins
David Laundy
Research12 May 1988
Nature

Volume: 333, P: 151-153
Solution structure of the ets domain of Fli-1 when bound to DNA

Heng Liang
Xiaohong Mao
Stephen W. Fesik
Research01 Dec 1994
Nature Structural Biology

Volume: 1, P: 871-876
Lineament and polygon patterns on Europa

David C. Pieri
Research01 Jan 1981
Nature

Volume: 289, P: 17-21
Nutrient depletion indicates high primary productivity in the Weddell Sea

Joe C. Jennings Jr
Louis I. Gordon
David M. Nelson
Research03 May 1984
Nature

Volume: 309, P: 51-54
The Production of Soluble and Cellular Interleukin-2 Receptors by Cord Blood Mononuclear Cells following In Vitro Activation

David L Nelson
Carole C Kurman
Laurence A Rubin
Research01 Feb 1986
Pediatric Research

Volume: 20, P: 136-139
Improved protein binder design using β-pairing targeted RFdiffusion

This study demonstrates the capability of deep learning protein design models in generating functionally validated β-strand pairing interfaces, expanding the structural diversity of de novo binding proteins and accessible target surfaces.

Isaac Sappington
Martin Toul
David Baker
ResearchOpen Access10 Jan 2026
Nature Communications

Volume: 17, P: 1-15
Lung disease in the cystic fibrosis mouse exposed to bacterial pathogens

Donald J. Davidson
Julia R. Dorin
David J. Porteous
Research01 Apr 1995
Nature Genetics

Volume: 9, P: 351-357
Light Inactivation of Focus Formation by Chicken Embryo Fibroblasts infected with Avian Sarcoma Virus in the Presence of 5-Bromodeoxyuridine

DAVID BOETTIGER
HOWARD M. TEMIN
Research14 Nov 1970
Nature

Volume: 228, P: 622-624
Circadian Mitotic Rhythm in Epiphyseal Cartilage

DAVID J. SIMMONS
Research30 May 1964
Nature

Volume: 202, P: 906-907
The power of genetic diversity in genome-wide association studies of lipids

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

Sarah E. Graham
Shoa L. Clarke
Cristen J. Willer
Research09 Dec 2021
Nature

Volume: 600, P: 675-679
Development of CD4⁻CD8⁺ cytotoxic T cells requires interactions with class I MHC determinants

Suzana Maruic-Galesic
David A. Stephany
Ada M. Kruisbeek
Research12 May 1988
Nature

Volume: 333, P: 180-183
Determination of the spin and parity of all-charm tetraquarks

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

A. Hayrapetyan
V. Makarenko
A. Snigirev
ResearchOpen Access03 Dec 2025
Nature

Volume: 648, P: 58-63
Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction

Multi-ancestry genome-wide and transcriptome-wide association studies of aortic stenosis identify more than 200 independent risk loci and provide insights into its genetic architecture.

Aeron M. Small
Ta-Yu Yang
George Thanassoulis
ResearchOpen Access19 Dec 2025
Nature Genetics

Volume: 58, P: 57-66
Safeguarding climate-resilient mangroves requires only a moderate increase in the global protected area

Mangrove ecosystems are facing severe climate threats. However, this study shows that strategically expanding protected areas to include the most climate-resilient sites can safeguard biodiversity and ecosystem services for the future, and this can be achieved with only a modest increase in protected area.

Alvise Dabalà
Christopher J. Brown
Anthony J. Richardson
ResearchOpen Access27 Jan 2026
Nature Communications

Volume: 17, P: 1-11
Passive direct air capture via evaporative carbonate crystallization

This work introduces a passive method for capturing CO₂ directly in the solid form using a carbonate crystallizer. This system harnesses wind-driven evaporation to enable rapid CO₂ capture and carbonate crystallization. This method provides a simplified and scalable alternative to conventional air contactors, which require substantial capital investments.

Dongha Kim
Shijie Liu
David Sinton
Research27 Nov 2025
Nature Chemical Engineering

Volume: 2, P: 736-746
Increased mu opioid receptor binding detected by PET in cocaine–dependent men is associated with cocaine craving

Jon-Kar Zubieta
David A. Gorelick
J. James Frost
Research01 Nov 1996
Nature Medicine

Volume: 2, P: 1225-1229
Bioactivation of leukotoxins to their toxic diols by epoxide hydrolase

Mehran F. Moghaddam
David F. Grant
Bruce D. Hammock
Research01 May 1997
Nature Medicine

Volume: 3, P: 562-566
Length of uninterrupted CGG repeats determines instability in the FMR1 gene

Evan E. Eichler
Jeanette J.A. Holden
David L. Nelson
Research01 Sept 1994
Nature Genetics

Volume: 8, P: 88-94
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Research11 Mar 2021
Nature

Volume: 593, P: 136-141
Resistance of microorganisms to disinfection in dental and medical devices

David L. Lewis
Max Arens
Research01 Sept 1995
Nature Medicine

Volume: 1, P: 956-958
Broad-line high-excitation gas in the elliptical galaxy NGC5128

M. M. Phillips
Keith Taylor
R. N. Hook
Research16 Aug 1984
Nature

Volume: 310, P: 554-557
New evidence on the origin of rotation measures in extragalactic radio sources

P. P. Kronberg
Martine Simard-Normandin
Research01 Oct 1976
Nature

Volume: 263, P: 653-656

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