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Optical heterostructures have potential in integrated photonics and optoelectronics but are challenging to prepare in single-component systems. Here, the authors report an intrinsic optical heterostructure in an organic nanosheet, with enhanced fluorescence in an inner zone.

Nitric oxide (NO) is an important gaseous signaling molecule with multiple physiological roles in cardiovascular system. Here the authors develop a cardiac patch with NO releasing function that favors heart repair after myocardial infarction.

In a multicenter research program coordinated by the International Mouse Phenotyping Consortium, Spielmann et al. analyze the cardiac function and structure in ~4,000 monogenic mutant mice and identify 705 mouse genes involved in cardiac function, 75% of which have not been previously linked to cardiac heritable disease in humans. Using the UK Biobank human data, the authors validate the link between cardiovascular disease and some of the newly identified genes to illustrate the resource value and potential of their mutant mouse collection.

Operando synchrotron experiments reveal the Mn dissolution/redeposition dynamics in Mn-containing cathodes and offer insights into the regulation of Mn dissolution using ion-capturing polymers.

Spontaneous parthenogenesis in sunflower has been used to develop a scalable doubled haploid breeding system.

The kink structure in the band dispersion can be linked to electron-boson interaction and has been reported in unconventional superconductors. Here the authors observe an orbital selective and momentum dependent kink feature in an Fe-based superconductor, which is highly correlated with superconductivity.

Building an efficient proton-exchange membrane water electrolyzer with low Ir loading remains important but challenging. Here, the authors report an Ir/MnO_x catalyst with rich Ir-O-Mn bonds that serve as charge-transfer channels to generate and stabilize active Ir³⁺ species, enhancing both activity and stability.

Examining the in-plane spin components of the noncoplanar antiferromagnet manganese ditelluride provides spectroscopic and computational evidence of materials with a new type of plaid-like spin splitting in the antiferromagnetic ground state.

Targeted deletion of integrin-associated protein CD47 enhances long-term engraftment of human CD34⁺ cells in immunodeficient pigs lacking IL2RG and RAG2, enabling large-scale production of functional human immune cells.

In this paper, a new type of cardiac progenitor, marked by the transcription factor Wt1, is shown to reside in the proepicardium and epicardium. It is shown that during normal heart development, a subset of Wt1⁺ precursors differentiated into fully functional cardiomyocytes, and they arise from Wt1 progenitors that express Nkx2-5 and Isl1, suggesting that they share a developmental origin with multipotent Nkx2 5⁺/Isl1⁺ progenitors.

Other factors in addition to volcanism might have contributed to carbon cycle disturbances during the late Paleozoic ice age, according to results from high-resolution carbon and mercury isotope analyses of late Gzhelian to early Kungurian sediments from the North China Craton.

Gene editing induces paternal haploid plants in hexaploid wheat.

Atomically thin alloys are promising electrocatalysts but suffer from poor homogeneity. Here a multi-element metallene system is synthesized using an auto-catalytic method. The hexagonal close-packed intermetallic structure and isolated surface Ru–O₃ sites provide optimal adsorption of intermediates, contributing to high hydrogen oxidation activity and stability.

Lentiviruses co-packaging SpCas9 mRNA and an expression cassette encoding for a guide RNA targeting the Vegfa gene prevent mice from developing wet age-related macular degeneration induced by Vegfa. [Summary amended to correct the description of the packaged cargo.]

Zwitterionic additives composed of a ‘soft’ organic cation and a ‘hard’ anion enable homogeneous halide cycling in aqueous halide redox flow batteries, resulting in improved cycling life and stability.

Scalable synthesis of stable Cu clusters for heterogeneous catalysis is still a major challenge. Here the authors report a low-temperature atomic diffusion approach for synthesis of stable Cu cluster catalysts, which exhibit high yield of intermediate product in consecutive hydrogenation reactions.

Aqueous organic redox flow batteries (AORFBs) are a promising grid-scale energy storage technology, but the development of high-performance catholytes has been challenging. Here the researchers reveal redox-active species based on dimers of (2,2,6,6-tetramethylpiperidin-1-yl)oxyl that demonstrate high cycling stability, power and volumetric capacity in AORFBs.

Lack of stability in RuO₂-based catalysts at industrial currents impedes their use in green hydrogen production. Here, the authors show that incorporating lanthanide elements into RuO_x shields against external factors, enabling fine-tuned Ru-O covalency for durable oxygen evolution reaction electrocatalysis.

Sun and colleagues describe that the secretion of interleukin-33 is dependent on a p40 N-terminal fragment of gasdermin D, whose generation is independent of inflammatory caspase-1 and caspase-11.

Nanoparticles are being explored as a potential method to target Aβ aggregation in Alzheimer’s disease. Here, the authors develop gold nanoparticles that were capped with chiral L or D-glutathione which has been shown to improve BBB permeability and demonstrate their ability to improve cognitive function in a mouse model of AD.

The genome of the scallop Patinopecten yessoensis is sequenced. This bivalve mollusc has a slow-evolving genome with features such as karyotype and Hox gene expression that may be close to that of the ancestral bilaterian.

Spin-triplet energy transfer in molecular systems underlies important applications for chemistry and devices. Here, the authors investigate the triplet energy transfer in CdSe quantum dots with varying ZnS shell thicknesses to surface-anchored anthracene molecules and identify a stepwise mechanism mediated by endothermic charge-transfer states.

Identification and characterization, using a comprehensive embryonic phenotyping pipeline, of 410 lethal alleles during the generation of the first 1,751 of 5,000 unique gene knockouts produced by the International Mouse Phenotyping Consortium.

Bivalve molluscs have evolved various characteristics to adapt to benthic filter-feeding. Here, Li et al investigate the genome, transcriptomes and proteomes of scallop Chlamys farreri, revealing evidences of molecular adaptations to semi-sessile life and neurotoxins.

The anomalous Hall effect and anomalous Nernst effect are signature transport features for exploring the physics of magnetic topological phases. Here, an anomalous Nernst effect of 1.8 ≈μV/K and an unconventional anomalous Hall effect which does not scale with the magnetization are observed in a metallic tetragonal antiferromagnet.

van der Waals ferroelectrics are different from conventional oxide or polymer-based ferroelectrics in terms of both crystal structure and functionality. This Review discusses the experimentally verified van der Waals ferroelectrics, their unique characteristics and their potential applications in post-Moore’s law electronics.