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Magnetic tunnel junctions face challenges in emulating neuromorphic devices within a single film stack platform. Chen et al. fabricate spintronics-based artificial synapses and spiking neurons and implement a convolutional spiking neural network, showing 96% accuracy in a gesture recognition task.

Building a trustworthy and effective healthcare AI ecosystem requires a scheme that embodies fairness, communication-efficient characteristics, and enhanced privacy protection. Here, the authors develop a framework for healthcare institutions with varying resources to fairly collaborate on AI training while protecting patient privacy, ensuring equitable access to high-quality medical AI regardless of resource constraints.

In this phase 3 trial, first-line treatment of patients with recurrent or metastatic head and neck squamous cell carcinoma with anti-PD-1 finotonlimab plus cisplatin plus 5-fluorouracil (C5F) prolonged overall survival compared with placebo plus C5F.

Uncontrollable bleeding is a major problem in surgery and after trauma. Here the authors design a photo-reactive adhesive that mimics the composition of connective tissue and is able to stop high pressure bleeding within half a minute.

Aging increases the risk for Alzheimer’s disease (AD). Here, the authors present a spatial transcriptome atlas of the human prefrontal cortex in AD, revealing distinct transcriptional alterations.

This study presents a microorganism electrocatalyst for the cathode of a microbial fuel cell that allows simultaneous electricity generation and treatment of sewage.

Electrochemical oxygen removal holds great potential for food preservation, but high costs and limited durability limit its adoption. Here, the authors report a membrane-free, gravity-driven reactor, providing a cost-effective, durable solution for long-term operation in household food preservation.

The brain is constantly monitoring the systems in the body. Here the authors use 7 Tesla functional magnetic resonance imaging to map a large-scale brain system for body regulation in humans, including brainstem nuclei, and confirm many monosynaptic connections traced in nonhuman animals.

Bimetallic nanoparticles with tailored structure constitute a desirable model system for catalysts. PtAu nanoparticles with Pt single-atom surface sites, prepared by a colloidal method, exhibit unprecedented electrocatalytic activity for formic acid oxidation.

Cell free RNA is a potentially valuable resource to detect cancer, however, its low concentration in plasma can limit usefulness. Here, the authors devise a library preparation method from 100ul of plasma, and apply to multiple cancer types to detect and classify cancer patients

Gut microbiota has been reported to influence osteoporosis risk, but the individual species, and underlying mechanisms, remain largely unknown. Here, the authors identify Bacteroides vulgatus and serum valeric acid as potential targets for osteoporosis prevention/treatment.

Resonant X-ray excitation of the  ⁴⁵Sc nuclear isomeric state was achieved by irradiation of a Sc-metal foil with 12.4-keV photon pulses from a state-of-the-art X-ray free-electron laser, allowing a high-precision determination of the transition energy.

The exoplanet HD 189733b has a metal-enriched atmosphere with the possible presence of H₂O (13.4σ), CO₂ (11.2σ), CO (5σ) and H₂S (4.5σ).

Patients with Type 2 Diabetes Mellitus are increasingly susceptible to atherosclerotic plaque vulnerability. Here, the authors show that elevated palmitic acid levels are linked to increased atherosclerotic plaque vulnerability.

Long-term variability of the North Pacific Subtropical Gyre (NPSG) circulation is not well understood. Here, the authors present data from different boundary currents that shows an enhanced NPSG circulation since ~3000-4000 years ago, linked to a southward migration of the Intertropical Convergence Zone.

A photonic Terahertz source based on injection-locking an integrated dual-laser chip generates and transmits a 131 Gbps THz signal over 10.7-m distance, showing great potential towards fully integrated and energy-efficient THz transmitters for 6G.

Control over the luminescence lifetimes of upconversion nanocrystals allows a new form of temporal multiplexing for imaging and data-storage applications.

The authors identified a protective genetic allele associated with lower PU.1 (SPI1) expression in myeloid cells by conducting a genome-wide scan of Alzheimer's disease (AD). PU.1 binds the promoters of AD-associated genes (e.g., CD33, MS4A4A & MS4A6A, TYROBP) and modulates their expression, suggesting it may reduce AD risk by regulating myeloid cell gene expression.

Atomic-level control over size, shape and surface composition of nanoparticles is vital for developing materials with integrated multiple functionalities. Here, the authors probe the different roles of oleate ions and oleic acid molecules and their effects on growth mechanisms for sub-50 nm nanoparticles.

Multi-omics profiling of the blood and heart of two human decedents receiving pig heart xenografts, including single-cell studies, reveals early immune responses and perioperative cardiac xenograft dysfunction in one of the two decedents, which may be due to mismatched heart size and/or insufficient immunosuppression.

Frequency dependent impairment degrades the transmission performance but its accurate calibration is still challenging due to the complex polarization. Dai, Zhang and colleagues report a calibration method able to simultaneously calibrate various frequency-dependent impairments in coherent optical transceivers, with a measured bit error rate improvement from 1.61e^-1 to 4.41e^-2 after calibration.

The Spitzer Space Telescope launched when the study of exoplanets was in its infancy, and yet it was remarkably successful in characterizing both exoplanet and brown dwarf systems through their mid-infrared emissions. This Review collates the highlights of Spitzer-based research in these fields.

Global circulation theory predicts strong equatorial jets at the equators of hot gas giant exoplanets that blow hot gas to the east, resulting in an eastward hotspot. Here, Dang et al. present a detection of a hotspot significantly offset to the west.

Hanwen Luo and colleagues report a device-compatible ultra-high-order quantum noise stream cipher encrypted method. The approach flexibly regulates the data transmission rate and security performance of high-speed long-distance communications networks.