Nature Search

Smad3 is essential for polarization of tumor-associated neutrophils in non-small cell lung carcinoma

TGF-β stimulated tumor-associated neutrophils (TANs) can exert pro-tumoral functions. Here the authors show that Smad3 activation in TANs is associated with an N2-like polarization state and poor outcome in patients with non-small cell lung carcinoma and that Smad3 targeting reprograms TANs to an antitumor state suppressing tumor growth in preclinical lung cancer models.

Jeff Yat-Fai Chung
Philip Chiu-Tsun Tang
Patrick Ming-Kuen Tang
ResearchOpen Access31 Mar 2023
Nature Communications

Volume: 14, P: 1-17
Atomic mechanisms of full-length ASC-mediated inflammasome assembly

Inflammasomes are immune complexes built around the adaptor ASC (Apoptosis-associated Speck-like protein containing a CARD). Here, authors solve atomic structures of full-length ASC filaments, show that Caspase-1 starts at one filament end, and reveal a multitrack assembly model explaining rapid activation.

Dongmei Xue
Fengyun Ni
Jianpeng Ma
ResearchOpen Access26 Nov 2025
Nature Communications

Volume: 16, P: 1-15
Fintech empowerment and the new-quality productivity of enterprises: empirical evidence from Chinese listed companies

Yangyang Sun
Hanqin Wang
Dongmei Wang
ResearchOpen Access21 Nov 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-15
NINJ1 regulates plasma membrane fragility under mechanical strain

The NINJ1 protein regulates plasma membrane rupture by altering membrane biomechanical properties, independent of cell death programs.

Yunfeng Zhu
Fang Xiao
Jie Xu
ResearchOpen Access09 Jun 2025
Nature

Volume: 644, P: 1088-1096
Publisher Correction: NINJ1 regulates plasma membrane fragility under mechanical strain

Yunfeng Zhu
Fang Xiao
Jie Xu
Amendments and CorrectionsOpen Access06 Aug 2025
Nature

Volume: 644, P: E38
Spatiotemporal Airy Ince–Gaussian wave packets in strongly nonlocal nonlinear media

Xi Peng
Jingli Zhuang
Dongmei Deng
ResearchOpen Access08 Mar 2018
Scientific Reports

Volume: 8, P: 1-10
Label-free and Non-destruction Determination of Single- and Double-Strand DNA based on Quantum Weak Measurement

Tian Guan
Yuxuan Yang
Xiangnan Wang
ResearchOpen Access13 Feb 2019
Scientific Reports

Volume: 9, P: 1-8
Glucocorticoid inhibits lung cancer cells proliferation and migration by suppressing smad2/3 activation

Lei Xu
Qi Li
Yi Tan
ResearchOpen Access08 Dec 2025
Scientific Reports

Volume: 16, P: 1-18
Regulating three-layer full carbon electrodes to enhance the cell performance of CsPbI₃ perovskite solar cells

The device efficiency of carbon-based perovskite solar cells remains unsatisfactory. Here, the authors design a triple-layer full-carbon electrode with carbon quantum dots decorated on macro-porous carbon layer, realizing certified efficiency of over 19% for n-i-p CsPbI3 perovskite solar cells.

Bingcheng Yu
Jiangjian Shi
Qingbo Meng
ResearchOpen Access08 Apr 2025
Nature Communications

Volume: 16, P: 1-10
ENO2-derived phosphoenolpyruvate functions as an endogenous inhibitor of HDAC1 and confers resistance to antiangiogenic therapy

In this study, Wang et al. show that the glycolytic metabolite phosphoenolpyruvate, produced by enolase 2, contributes to colorectal cancer malignancy and resistance to antiangiogenic therapy by inhibiting endogenous histone deacetylase 1 and favouring β-catenin signalling.

Chenran Wang
Maohua Huang
Wencai Ye
Research04 Sept 2023
Nature Metabolism

Volume: 5, P: 1765-1786
Genome-wide association study identifies common variants in SLC39A6 associated with length of survival in esophageal squamous-cell carcinoma

Dongxin Lin and colleagues report a genome-wide association study identifying common variants in SLC39A6 associated with length of survival in individuals with esophageal squamous-cell carcinoma (ESCC). Higher expression of SLC39A6 in esophageal tissues was correlated reduced survival time in individuals with ESCC.

Chen Wu
Dong Li
Dongxin Lin
Research05 May 2013
Nature Genetics

Volume: 45, P: 632-638
Excessive miR-25-3p maturation via N⁶-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression

Cigarette smoke induces microRNA dysregulation in cancers. Here, the authors show that cigarette smoke promotes the maturation of oncogenic primary miR-25 due to METTL3 hypomethylation, and mature miR-25 suppresses PH domain leucine-rich repeat protein phosphatase 2, resulting in oncogenic AKT activation in pancreatic cancer.

Jialiang Zhang
Ruihong Bai
Dongxin Lin
ResearchOpen Access23 Apr 2019
Nature Communications

Volume: 10, P: 1-15
Author Correction: PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications

Junchao Shi
Yunfang Zhang
Qi Chen
Amendments and Corrections29 Apr 2021
Nature Cell Biology

Volume: 23, P: 676
Revealing the rural multifunctionality declining and its causes in depopulated regions of Northeast China: a case study of Heilongjiang Province

Dongmei Li
Qing Wen
Guoming Du
ResearchOpen Access09 Jan 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-12
Study on bearing strength of fiber reinforced polymer anchoring cable in deep roadway

Lei Wang
Yilin Wu
Yiwen Zhang
ResearchOpen Access10 Feb 2025
Scientific Reports

Volume: 15, P: 1-15
Single-cell transcriptomic analysis of the tumor ecosystems underlying initiation and progression of papillary thyroid carcinoma

The characterisation of the papillary thyroid carcinoma (PTC) tumour microenvironment remains crucial. Here, the authors perform single-cell RNA sequencing in 11 patients and identify potential opportunities for the use of immunotherapy and its combination with anti-angiogenic therapy in PTC.

Weilin Pu
Xiao Shi
Yu-Long Wang
ResearchOpen Access18 Oct 2021
Nature Communications

Volume: 12, P: 1-18
PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications

Shi et al. profiled small non-coding RNAs (sncRNAs) through PANDORA-seq, which identified tissue-specific transfer RNA- and ribosomal RNA-derived small RNAs, as well as sncRNAs, with dynamic changes during induced pluripotent stem cell reprogramming.

Junchao Shi
Yunfang Zhang
Qi Chen
Research05 Apr 2021
Nature Cell Biology

Volume: 23, P: 424-436
Chrdl1-mediated BMP4 inhibition disrupts the balance between retinal neurons and Müller Glia

Dongmei Liu
Zeyuan Pu
Yin Shen
ResearchOpen Access17 Aug 2024
Cell Death Discovery

Volume: 10, P: 1-12
Correction: MZF1 mediates oncogene-induced senescence by promoting the transcription of p16^INK4A

Dan Wu
Hua Tan
Peiqing Sun
Amendments and Corrections29 Nov 2024
Oncogene

Volume: 44, P: 272-275
Spatial–temporal combination and multi-head flow-attention network for traffic flow prediction

Lianfei Yu
Wenbo Liu
Panjing Li
ResearchOpen Access26 Apr 2024
Scientific Reports

Volume: 14, P: 1-18
Convergence effect of the Belt and Road Initiative on income disparity: evidence from China

Bo Qin
Dongmei Zeng
Angang Gao
ResearchOpen Access12 Sept 2022
Humanities and Social Sciences Communications

Volume: 9, P: 1-16
A multicenter, prospective, observational study to determine association of mesangial C1q deposition with renal outcomes in IgA nephropathy

Li Tan
Yi Tang
Wei Qin
ResearchOpen Access09 Mar 2021
Scientific Reports

Volume: 11, P: 1-10
MZF1 mediates oncogene-induced senescence by promoting the transcription of p16^INK4A

Dan Wu
Hua Tan
Peiqing Sun
Research12 Nov 2021
Oncogene

Volume: 41, P: 414-426
High-density genetic map construction and comparative genome analysis in asparagus bean

Haitao Huang
Huaqiang Tan
Huanxiu Li
ResearchOpen Access19 Mar 2018
Scientific Reports

Volume: 8, P: 1-9
SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1

Di Wang
Weiwei Liang
Honglin Feng
ResearchOpen Access28 Nov 2022
Cell Death & Differentiation

Volume: 30, P: 369-382
Chromosome-level genome assemblies of five Prunus species and genome-wide association studies for key agronomic traits in peach

Qiuping Tan
Sen Li
Ling Li
ResearchOpen Access01 Oct 2021
Horticulture Research

Volume: 8, P: 1-18
Her2 promotes early dissemination of breast cancer by suppressing the p38-MK2-Hsp27 pathway that is targetable by Wip1 inhibition

Juan Wang
Guanwen Wang
Peiqing Sun
Research26 Aug 2020
Oncogene

Volume: 39, P: 6313-6326
The emerging sub-genotype C2 of CoxsackievirusA10 Associated with Hand, Foot and Mouth Disease extensively circulating in mainland of China

Tianjiao Ji
Yue Guo
Wenbo Xu
ResearchOpen Access06 Sept 2018
Scientific Reports

Volume: 8, P: 1-10
Inapparent Streptococcus agalactiae infection in adult/commercial tilapia

Jiufeng Sun
Wei Fang
Xiaoling Deng
ResearchOpen Access24 May 2016
Scientific Reports

Volume: 6, P: 1-11

Search

Smad3 is essential for polarization of tumor-associated neutrophils in non-small cell lung carcinoma

Atomic mechanisms of full-length ASC-mediated inflammasome assembly

Fintech empowerment and the new-quality productivity of enterprises: empirical evidence from Chinese listed companies

NINJ1 regulates plasma membrane fragility under mechanical strain

Publisher Correction: NINJ1 regulates plasma membrane fragility under mechanical strain

Spatiotemporal Airy Ince–Gaussian wave packets in strongly nonlocal nonlinear media

Label-free and Non-destruction Determination of Single- and Double-Strand DNA based on Quantum Weak Measurement

Glucocorticoid inhibits lung cancer cells proliferation and migration by suppressing smad2/3 activation

Regulating three-layer full carbon electrodes to enhance the cell performance of CsPbI₃ perovskite solar cells

ENO2-derived phosphoenolpyruvate functions as an endogenous inhibitor of HDAC1 and confers resistance to antiangiogenic therapy

Genome-wide association study identifies common variants in SLC39A6 associated with length of survival in esophageal squamous-cell carcinoma

Excessive miR-25-3p maturation via N⁶-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression

Author Correction: PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications

Revealing the rural multifunctionality declining and its causes in depopulated regions of Northeast China: a case study of Heilongjiang Province

Study on bearing strength of fiber reinforced polymer anchoring cable in deep roadway

Single-cell transcriptomic analysis of the tumor ecosystems underlying initiation and progression of papillary thyroid carcinoma

PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications

Chrdl1-mediated BMP4 inhibition disrupts the balance between retinal neurons and Müller Glia

Correction: MZF1 mediates oncogene-induced senescence by promoting the transcription of p16^INK4A

Spatial–temporal combination and multi-head flow-attention network for traffic flow prediction

Convergence effect of the Belt and Road Initiative on income disparity: evidence from China

A multicenter, prospective, observational study to determine association of mesangial C1q deposition with renal outcomes in IgA nephropathy

MZF1 mediates oncogene-induced senescence by promoting the transcription of p16^INK4A

High-density genetic map construction and comparative genome analysis in asparagus bean

SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1

Chromosome-level genome assemblies of five Prunus species and genome-wide association studies for key agronomic traits in peach

Her2 promotes early dissemination of breast cancer by suppressing the p38-MK2-Hsp27 pathway that is targetable by Wip1 inhibition

The emerging sub-genotype C2 of CoxsackievirusA10 Associated with Hand, Foot and Mouth Disease extensively circulating in mainland of China

Inapparent Streptococcus agalactiae infection in adult/commercial tilapia

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