Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–15 of 15 results
Advanced filters: Author: Dorota Klepacki Clear advanced filters

  • Hybrids of macrolides and quinolones, called macrolones, can overcome macrolide-induced resistance through new interactions between the quinolone moiety and the ribosome and can concurrently inhibit both ribosome and DNA gyrase targets.

    • Elena V. Aleksandrova
    • Cong-Xuan Ma
    • Alexander S. Mankin
    Research
    Nature Chemical Biology
    Volume: 20, P: 1680-1690

  • A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common resistance mechanisms and shows no toxicity towards human cells.

    • Manoj Jangra
    • Dmitrii Y. Travin
    • Gerard D. Wright
    Research
    Nature
    Volume: 640, P: 1022-1030

  • The antimicrobial peptide Drosocin encoded in the fruit fly genome inhibits bacterial translation by stalling the ribosomes at stop codons, sequestering class 1 release factors and inducing stop codon readthrough. Comprehensive mutational analysis reveals key activity determinants of Drosocin.

    • Kyle Mangano
    • Dorota Klepacki
    • Alexander S. Mankin
    Research
    Nature Chemical Biology
    Volume: 19, P: 1082-1090

  • Macrolide antibiotics inhibit bacterial translation in a context-specific manner, arresting ribosomes at defined sites within mRNAs and selectively inhibiting synthesis of only a subset of cellular proteins. Here the authors provide a structural basis for the context-specific activity of macrolides on the eukaryotic ribosome.

    • Maxim S. Svetlov
    • Timm O. Koller
    • Alexander S. Mankin
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Bacteria adjust the expression of some of their metabolic enzymes through metabolite-sensing ribosome nascent chain complexes. Here the authors present a cryo-EM structure of an E. coli ribosome stalled during translation of the TnaC leader peptide and propose a model for L-Trp dependent ribosome stalling where L-Trp competes with release factor 2 for binding to the TnaC-ribosome complex.

    • Anne-Xander van der Stel
    • Emily R. Gordon
    • C. Axel Innis
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • The authors determine the cryo-EM structures of prokaryotic ribosomes with the oxazolidinone antibiotics linezolid and radezolid bound to the peptidyl transferase center with an adjacent growing nascent peptide chain, providing an explanation for their context-specific action.

    • Kaitlyn Tsai
    • Vanja Stojković
    • Danica Galonić Fujimori
    Research
    Nature Structural & Molecular Biology
    Volume: 29, P: 162-171

  • Structure-guided design and component-based synthesis are used to produce iboxamycin, a novel ribosome-binding antibiotic with potent activity against Gram-positive and Gram-negative bacteria.

    • Matthew J. Mitcheltree
    • Amarnath Pisipati
    • Andrew G. Myers
    Research
    Nature
    Volume: 599, P: 507-512

  • The tethered ribosome system Ribo-T supports cell proliferation though at a reduced rate. Here the authors show this is due to slower ribosome assembly instead of reduced functionality.

    • Nikolay A. Aleksashin
    • Margus Leppik
    • Alexander S. Mankin
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Ribosomes of all organisms have retained 5S rRNA as an autonomous rRNA species. Here the authors engineer a bacterial strain with ribosomes that do not have free 5S rRNA, and carry structural analyses that suggest the evolutionary preservation of 5S rRNA as an independent molecule is based on its role in the dynamic process of ribosome biogenesis.

    • Shijie Huang
    • Nikolay A. Aleksashin
    • Alexander S. Mankin
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • Evernimicin, an antibiotic of the orthosomycin class, inhibits bacterial translation by preventing ribosomes from polymerizing specific amino acid motifs, and controls the expression of resistance genes via such context-specific action.

    • Kyle Mangano
    • James Marks
    • Alexander S. Mankin
    Research
    Nature Chemical Biology
    Volume: 18, P: 1277-1286