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Epidemiology of yellow fever suggests that other flaviviruses may provide some level of cross-protection. Here the authors show in a non-human primate model that pre-existing dengue-2 or Zika virus immunity results in lower yellow fever viremia compared to naïve animals, limiting the transmission potential by Aedes aegypti mosquitoes.

The online food delivery and takeaway market is growing in China, serving 406 million customers with 10.0 billion orders in 2018. Here, data from an online food delivery platform, life-cycle environmental impacts of packaging and tableware waste generated across 353 cities in China, and scenarios for paper alternatives and tableware sharing are presented.

ZUFSP-type enzymes cleave ubiquitin chains in a linkage-specific fashion, but members from different organisms have different specificities. Using an inter-kingdom comparison of activities and structures, the authors identify the domains responsible for this discrepancy.

Hepatitis B virus X protein (HBx) binds anti-apoptotic Bcl-xL through its BH3-like motif to promote viral replication. Here, the authors provide the structure of the HBx BH3-like domain and Bcl-xL, which shows an unusual mode of interaction, and identify a short peptide that inhibits HBV replication in cultured human hepatic cells.

Despite decades of research, autonomous robotic manipulation skills remain limited, especially for complex tasks such as insertion or bending of materials. Johannsmeier et al. introduce a taxonomy of manipulation skills that synthesizes tactile behaviours from process specifications, achieving high robustness and performance with minimal learning time.

ZAC is a Zn²⁺ and H⁺-activated cation channel. Here, the authors report the structures of human ZAC and identify an unusual C-tail that functions in auto-inhibition. This work provides insights into the gating and activation mechanisms of ZAC.

Traditional prosthetic hands have limited degrees of freedom (DOFs) and restricted grasping modes. Here, the authors develop a lightweight (370 g) biomimetic prosthetic hand with 19-DOF driven by shape memory alloy actuators.

This paper describes and models a striking example of non-random ecological patterning over large spatial scales apparently caused by the interaction between a common species of tropical arboreal ant and one of its natural enemies under spatially homogeneous conditions.

Vector saliva can affect infectivity and pathogenesis of vector-borne viruses, but this hasn’t been studied for Zika virus infection. Here, Dudley et al. show that mosquito-mediated Zika infection of macaques results in altered replication kinetics and greater sequence heterogeneity.

Parasitoid flies eavesdrop on the mating songs of male Hawaiian crickets, creating conflict between sexual and natural selection. Here, the authors investigate the selection acting on a recently evolved male mating signal, a “purring” song, which appears to be undetected by parasitoids.

The U2 snRNP recognizes the intron during spliceosome assembly. Here the authors report the high-resolution structures of two assembly precursors of human U2 snRNP and reveal that the RNA helicases DDX42 and DDX46 are mutually exclusive in terms of SF3B1-binding.

Cyclized or folded single-chain polymeric nano-objects are generally produced with low efficiency. Here, the authors have scaled up the preparation of supramolecular single-chain nanogels by RAFT polymerizations and applied the dynamic supramolecular single-chain nanogels to regulate cell behaviours at varying scales.

The Shaxi non-arc porphyry copper deposit in China was produced by the injection of oxidised mafic melts through a Neoproterozoic root zone from which copper and gold were extracted and transported, according to geochemical and petrological analyses

The basalt V-Ti redox proxy indicates that both of the Archean ambient and modified mantle exhibit a ~1.0 log unit increase in their evolution for most cratons, possibly derived by widespread crustal recycling.

Modification of RNA with N6-methyladenosine can regulate RNA metabolism. Here they developed scm⁶A-seq to profile the methylome and transcriptome in single cells, and reveal the functions of m⁶A modification during oocyte maturation and early embryo development.

The Rustenburg Layered Suite of the Bushveld Complex, South Africa, has long been regarded as a textbook result of fractional crystallization from a melt-dominated magma chamber. Here, the authors find that the Rustenburg Layered Suite can be derived from crustal assimilation by komatiitic magma to form magmatic mushes without requiring the existence of a magma chamber by using thermodynamic models.

Developing physical methods to modulate biomolecular condensates on cell membranes is of great importance for understanding physiological processes and stimulating novel therapeutic strategies. We propose an effective means to control receptor condensation on cell membranes via adhesion to a supported lipid bilayer with nanoscale topography.

The ZIP family (SLC39A) is involved in transition metal homeostasis. Here, authors use integrated approaches to conclude that the ZIP from Bordetella bronchiseptica (BbZIP) utilizes the elevator-type transport mechanism to achieve alternating access.

Carbon capture is increasingly important to address current environmental challenges but developing effective carbon capture materials is challenging. Here, the authors report liquid marble-derived superparticles which overcome current limitations associated with both liquid and solid carbon capture materials.

The proteasome activator PA28αβ affects MHC class I antigen presentation by associating with immunoproteasome core particles (iCPs). Cryo-EM structures of the mammalian PA28αβ -iCP immunoproteasome and free iCP, combined with cross-linking data, reveal the complex architecture and suggest a distinct immunoproteasome activation mechanism.

In Caenorhabditis elegans, genome instability in the form of exogenous and endogenous DNA damage in germ cells evokes elevated heat- and oxidative-stress resistance in somatic tissues; this is mediated by MPK-1, which triggers the induction of putative secreted peptides associated with innate immunity, leading to activation of the ubiquitin–proteasome system.

This work reveals a eukaryotic ribosome elongation cycle in situ, uncovers over 20 structural conformations, highlights the new role of compact eukaryotic elongation factor 2 (eEF2) during peptidyl transfer and discovers new conformations of open-eEF3.

Under field conditions, acquisitive tree species generally grow slowly, whereas conservative species show generally higher realized growth, owing to their ability to tolerate unfavourable environmental conditions.

Here, the authors present the cryo-EM structures of two archaeal, halophilic, internal membrane-containing icosahedral viruses at 3.7 and 3.8 Å resolution, providing insights into the assembly process of these and related PRD1-adeno lineage viruses.