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Active galactic nuclei are surrounded by a dusty and molecular disk that fuels supermassive black holes and connects them to their host galaxies. Here, the authors show with JWST interferometric observations that most of the dust in the Circinus galaxies lies in a compact disk, while only a tiny fraction traces hot outflowing material.

A strongly lensed galaxy at redshift z ≈ 6 is resolved into at least 15 star-forming clumps embedded in a rotating disk. Clump formation in this system, which is not predicted by cosmological zoom-in simulations, may be driven by disk instabilities with weak feedback, rather than past mergers.

Five-year survival data and biomarker analysis of the PRADO extension cohort of the phase 2 OpACIN-neo trial, in which patients with high-risk stage III melanoma received neoadjuvant ipilimumab and nivolumab and underwent pathologic response-directed surgery and adjuvant therapy, show 71% event-free survival and 88% overall survival, with tumor mutational burden, IFNγ signature and PD-L1 expression associated with favorable outcomes.

De novo and inherited dominant variants in genes encoding U4 and U6 small nuclear RNAs are identified in individuals with retinitis pigmentosa. The variants cluster at nucleotide positions distinct from those implicated in neurodevelopmental disorders.

Measurements of polarized 1.25-mm continuum emission from the accretion disk of the T Tauri star HL Tau show that the magnetic field inside the disk cannot be dominated by a vertical component, and that a purely toroidal field also does not fit the data; this suggests that the role of the magnetic field in the accretion of a T Tauri star is more complex than the current theoretical understanding.

Analyzing data of the Mexican Biobank project, a new study finds regional differences in clinically relevant genetic frequencies and presents MexVar, a publicly accessible resource designed to support ancestry-informed genetic testing.

Measurements of the Rossiter–McLaughlin effect for the ultra-short-period super-Earth 55 Cancri e reveal a signal with a semi-amplitude of 0.41+0.09-0.10 m s⁻¹, in close alignment with its star and potentially misaligned with the other planets in the system. Such a configuration favours a non-violent migration pathway for 55 Cnc e.

Magnetic fields in stellar upper atmospheres are key to understanding stellar activity and its planetary effects. Here, the authors study chromospheric magnetic fields in three M-dwarf stars using spectropolarimetric observations, finding fields reaching hundreds of Gauss with complex height-dependent structures.

Analysis of 20 years of observations of Barnard’s star from seven facilities reveals a signal with a period of 233 days that is indicative of a companion planet.

Drug delivery implants suffer from diminished release profiles due to fibrous capsule formation over time. Here, the authors use soft robotic actuation to modulate the immune response of the host to maintain drug delivery over the longer-term and to perform controlled release in vivo.

Observations of a 3-million-year-old pre-main-sequence star with a misaligned disk reveal a giant orbiting planet; the system is ideal for studying the early formation and migration of planets.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

Current single-cell RNA sequencing methods struggle to comprehensively profile transcriptomes, with many lowly expressed transcripts remaining undetected. Here authors present a workflow for enhancing the detection of both transcripts and regions of interest in combination with a standard transcriptome profile.

Wind from the most massive star in the Trapezium cluster in Orion has carved out a large and expanding cavity around the cluster, bounded by a thin, 2,600-solar-mass shell.

Debate surrounds the causes, timing, and effects of the Cretaceous-Paleogene mass extinction, 66 Ma. Here, using new collections of marine macrofossils from Seymour Island, Antarctica, the authors show that the extinction was both rapid and severe in the high southern latitudes, contrary to previous studies.

Single cell transcriptomics can be used to identify genes associated with type 2 diabetes (T2D) and computational models can be used to identify gene networks. Here the authors identify networks of dysregulated genes in T2D and the biological processes involved, further demonstrating the functional context of the identified genes.

A large sulfur-bearing carbon ring molecule has been detected in space, 2,5-cyclohexadien-1-thione, using laboratory spectroscopy and a radio telescope. Found near the Galactic Centre, it opens the door to a new family of interstellar molecules.

Approximately 17% of meningiomas remain genomically uncharacterized. Here, the authors analyze 105 meningiomas without known driver mutations or significant copy number alterations and identify a subgroup of meningiomas, defined by FOS/FOSB gene fusions with distinctive transcriptomic and histopathological features.

Hutchinson-Gilford Progeria Syndrome is characterized by premature aging with cardiovascular disease being the main cause of death. Here the authors show that inhibition of the NAT10 enzyme enhances cardiac function and fitness, and reduces age-related phenotypes in a mouse model of premature aging.

Far-infrared polarimetric observations reveal a transition parallel to the gas flow in the orientation of magnetic field lines in the Serpens South molecular cloud, allowing gravitational collapse to occur even in the presence of strong magnetic fields.

New measurements of the metallicities of ultraluminous infrared galaxies show that observations of underabundances of metals in these galaxies are most probably due to heavy dust obscuration, rather than intrinsic metal-poor gas accretion.

When an extrasolar planet passes in front of its star (transits), its radius can be measured from the decrease in starlight and its orbital period from the time between transits. This study reports Kepler spacecraft observations of a single Sun-like star that reveal six transiting planets, five with orbital periods between 10 and 47 days plus a sixth one with a longer period. The five inner planets are among the smallest for which mass and size have both been measured, and these measurements imply substantial envelopes of light gases.

Using the GRAVITY+ instrument, dynamical measurement of the black hole mass in a quasar at a redshift of 2.3 (11 billion years ago) shows how the relationship between galaxies and black holes evolves with time.

Here the authors report a that sprint interval exercise triggers mitochondrial stress and quality control in skeletal muscle in young healthy men, promoting enhanced mitochondrial function and a remodelling after 8 weeks of training.

A previously unsampled deep lineage in central Argentina was discovered that had distinctive genetic drift by 8,500 bp and persisted as the main Native American ancestry component in the region up to the present day.

Magnetospheres of exoplanets are vast, tenuous and hard to detect. Deep blue-shifted absorption lines observed in the extended region around HAT-P-11 b may provide evidence for a magnetosphere and magnetotail.

The southern hemisphere of Betelgeuse during its Great Dimming was an order of magnitude darker than usual, owing to a cool patch on the photosphere and associated dust formation.

Linearly polarized thermal emission from dust grains in a strongly lensed, intrinsically luminous galaxy forming stars at a rate more than 1,000 times that of the Milky Way is detected.

The dayside thermal emission spectrum and brightness temperature map of the ultra-hot Jupiter WASP-18b obtained from the NIRISS instrument on the JWST showed water emission features, an atmosphere consistent with solar metallicity, as well as a steep and symmetrical decrease in temperature towards the nightside.

Measurement of the bound-state β⁻ decay of ²⁰⁵Tl⁸¹⁺ gives a new, longer half-life, allowing for the calculation of accurate stellar ²⁰⁵Pb yields and the isolation time of the early Solar System.

Post-drought rehydration triggers a preventive immune response in plants, revealing targets to enhance crop resilience by linking drought stress recovery with improved pathogen resistance.

Observations of TOI-849b reveal a radius smaller than Neptune’s but a large mass of about 40 Earth masses, indicating that the planet is the remnant core of a gas giant.

The warm Earth-sized planet LHS 475 b is validated and characterized with two transits observed by the JWST. The absence of evident spectroscopic features excludes a substantial hydrogen envelope and indicates that LHS 475 b has either little or no atmosphere or an optically thick cloud deck at high altitudes.

LTT 9779 b is Neptune-sized planet rotating around its star with a period of 0.79 days and an equilibrium temperature of 2,000 K. It is not clear how it retained its atmospheric envelope, which contains ~10% of H/He, as it should have been photoevaporated by now.

The transmission spectrum of the exoplanet WASP-39b is obtained using observations from the Single-Object Slitless Spectroscopy mode of the Near Infrared Imager and Slitless Spectrograph instrument aboard the JWST.

Genotype and exome sequencing of 150,000 participants and whole-genome sequencing of 9,950 selected individuals recruited into the Mexico City Prospective Study constitute a valuable, publicly available resource of non-European sequencing data.

Phase-resolved mid-infrared observations from JWST of the hot gas giant WASP-43b detect a day–night difference of 659 ± 19 K. Comparison with climate models shows that the observations are compatible with cloudy skies, at least on the nightside, and the lack of methane detection suggests the presence of disequilibrium chemistry.

Kidney organoids derived from human pluripotent stem cells are infused in a normothermic machine perfusion system to condition explanted porcine kidneys, and the feasibility and viability of their in vivo engraftment are demonstrated.

Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 receptor in myeloid cells.

The medium-resolution transmission spectrum of the exoplanet WASP-39b, described using observations from the Near Infrared Spectrograph G395H grating aboard JWST, shows significant absorption from CO₂ and H₂O and detection of SO₂.

The size of the inner disk of the T Tauri star TW Hydrae is determined using optical long-baseline interferometric observations, indicating that hydrogen emission comes from a region approximately 3.5 stellar radii across.

Time-series observations from the JWST of the transiting exoplanet WASP-39b show gaseous water in the planet’s atmosphere and place an upper limit on the abundance of methane.

A broad-wavelength 0.5–5.5 µm atmospheric transmission spectrum of WASP-39b, a 1,200 K, roughly Saturn-mass, Jupiter-radius exoplanet, demonstrates JWST’s sensitivity to a rich diversity of exoplanet compositions and chemical processes.